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Microbiology PhD Projects, Programs & Scholarships in Manchester

We have 37 Microbiology PhD Projects, Programs & Scholarships in Manchester

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  (MRC DTP) Can we use techniques such as machine learning to improve the risk prediction of infection-related complications in order to optimise antibiotic prescribing?
  Prof T Van Staa, Dr V Palin, Dr D Wong
Application Deadline: 15 November 2019

Funding Type

PhD Type

Antimicrobial resistance is a major public health concern and overuse of antibiotics is a major factor in its development. One strategic aim of the Government’s approach to minimise this is to conserve and steward the effectiveness of existing treatments by optimising antibiotic prescribing practices.
  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
  (MRC DTP) The importance of 24h rhythms in the gut microbiome for immunity
  Dr J Gibbs, Dr M Hepworth, Prof K Else
Application Deadline: 15 November 2019

Funding Type

PhD Type

The gut microbiome is a collection of trillions of organisms. These bacteria and the metabolites they produce (through the breakdown of dietary components) play a critical role in the maintenance of immunity.
  (MRC DTP) Manipulating macrophages to improve oral inflammation
  Dr J Konkel, Dr J Grainger
Application Deadline: 15 November 2019

Funding Type

PhD Type

State-of-the-art immunology research has revealed that immune-mediated inflammation of the mouth (periodontitis) is linked to development of bowel cancer, cardiovascular disease and rheumatoid arthritis (RA).
  (MRC DTP) Innate immune crosstalk and orchestration of mucosal immunity
  Dr M Hepworth, Prof A MacDonald
Application Deadline: 15 November 2019

Funding Type

PhD Type

Barrier tissue sites - including the gastrointestinal tract, lung and skin – are the primary site of exposure to a multitude of foreign organisms and environmental challenges.
  (MRC DTP) Longitudinal interactions between the respiratory metagenome and immune fitness
  Prof N Papadopoulos, Dr T Gilman
Application Deadline: 15 November 2019

Funding Type

PhD Type

An increasing body of evidence is linking microbiome composition with human health. Chronic inflammatory diseases, such as allergy and asthma, have been associated with dysbiotic microbiomes at both the gut and the respiratory niches.
  (MRC DTP) Model-based precision dosing of antibiotics in critically ill patients
  Dr K Ogungbenro, Dr T Felton
Application Deadline: 15 November 2019

Funding Type

PhD Type

Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality in adults and children worldwide1. In the UK, CAP accounts for over 100,000 hospital admissions annually.
  (MRC DTP) The oral microbiome, microbial metabolites and their impact upon local and systemic immunity
  Dr A McBain, Dr J Konkel
Application Deadline: 15 November 2019

Funding Type

PhD Type

Commensal microbes and the host immune system have formed an evolutionary partnership that is vital for the development, metabolism and defensive immunity of the host.
  (MRC DTP) Insulin-mediated antimicrobial secretion from pancreatic acinar cells regulates the gut microbiome and barrier function: Link between diabetes and severity of acute pancreatitis
  Dr J Bruce, Prof I Roberts, Dr J Pennock
Application Deadline: 15 November 2019

Funding Type

PhD Type

Acute pancreatitis is a serious and sometimes fatal inflammatory disease of the pancreas. Severe cases are characterised by infected pancreatic necrosis, sepsis and multiple organ failure, which increases mortality and prolongs critical care occupancy.
  (MRC DTP) Development of antifungal agents that target essential protein kinases in A. fumigatus
  Dr M Bromley, Dr L Tabernero
Application Deadline: 15 November 2019

Funding Type

PhD Type

A. fumigatus is the primary etiological agent of invasive aspergillosis, a disease that primarily affects individuals who are immunocompromised, and causes 200k life threatening infections annually.
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