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Microbiology PhD Projects, Programs & Scholarships in Manchester

We have 54 Microbiology PhD Projects, Programs & Scholarships in Manchester

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Showing 1 to 30 of 54
  Probing the organization and function of bacterial toxin-antitoxin complexes
  Dr F Hayes, Prof J P Derrick
Applications accepted all year round

Funding Type

PhD Type

Bacterial toxin-antitoxin (TA) modules typically consist of a pair of genes that encode for a stable toxin protein and an unstable cognate antitoxin molecule.
  Development of an in vitro model to dissect the mechanism of fungal persistence in the cystic fibrosis lung
  Prof P Bowyer, Dr M Bromley, Dr S Gago
Application Deadline: 28 February 2020

Funding Type

PhD Type

Cystic fibrosis (CF) is the most common fatal genetically inherited disease in Caucasian populations. This disease is caused by mutations in the cystic fibrosis transmembrane regulator gene (CFTR) which produces defective ion fluxes and calcium homeostasis in the epithelia.
  Nanoparticle conjugates for agricultural disease detection and diagnosis
  Dr L Wong, Prof J Micklefield
Applications accepted all year round

Funding Type

PhD Type

Infectious diseases in plant crops present a significant socioeconomic burden globally, as they compromise the safety and reliability of food supply, as well as other agricultural products.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  Chemical and enzymatic tools for pathogen glycobiology
  Prof R Field, Prof S Flitsch
Application Deadline: 31 January 2020

Funding Type

PhD Type

Dual-award between The University of Manchester and The University of Melbourne. This dual-award programme offers candidates the opportunity to apply for a project with a strong supervisory team both in Manchester and in Melbourne.
  Expanding the Genetic Code of a Synthetic Yeast
  Prof P Cai, Dr A Green
Applications accepted all year round

Funding Type

PhD Type

The proposed project aims to develop an efficient yeast-based protein expression platform with an expanded genetic code. The standard genetic code of natural organisms comprises 20 canonical amino acids.
  Investigating virus-host interactions in the killer yeast system (Manchester-Melbourne Dual Award)
  Dr J-M Schwartz
Application Deadline: 31 January 2020

Funding Type

PhD Type

Fungi, like all living organisms, may be infected by viruses, obligate intracellular parasites that hijack the host cell machinery in order to replicate.
  Human body temperature as a driver of fungal pathogenicity in the lung (Manchester-Melbourne Dual Award)
  Prof E Bignell, Dr M Bromley
Application Deadline: 31 January 2020

Funding Type

PhD Type

Fungal lung diseases are an often fatal consequence of spore inhalation which occur with high prevalence across the globe in settings of immune dysfunction and genetic risk.
  (A*STAR) Engineering pathways to next generation antibiotics
  Prof J Micklefield, Dr A Green
Application Deadline: 31 January 2020

Funding Type

PhD Type

The provision of new antibiotics to combat antimicrobial resistance (AMR) and to treat neglected tropical diseases (NTD), which are problematic in the developing world, is a major global challenge.
  (A*STAR) RNA-based sensors of host-imposed stress in the major fungal pathogen of human lungs: Potential as drug targets
  Prof E Bignell, Prof J Micklefield
Application Deadline: 31 January 2020

Funding Type

PhD Type

The often-fatal fungal lung disease invasive aspergillosis (IA) has claimed more than 8 million human lives since its. emergence ~ 40 years ago.
  (A*STAR) Unravelling the metabolic basis of Aspergillus fumigatus adaptation to combinatorial stress conditions
  Dr J Amich, Prof E Bignell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Aspergillus fumigatus is an environmental saprophytic fungus that lives ubiquitously in the soil. This fungus can also infect the lungs of individuals with any kind of immune imbalance, causing a broad range of diseases collectively termed aspergillosis.
  Tackling antibiotic resistance: developing a vaccine against gonorrhoea
  Prof J P Derrick, Dr F Hayes
Applications accepted all year round

Funding Type

PhD Type

Gonorrhoea is caused by the Gram-negative bacterium Neisseria gonorrhoeae and is a serious public health problem in developing and developed countries.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
  Investigating the Causal Biological Effects on Microbial Induced Corrosion (MIC) Occurring Within Components of Advanced Maritime Systems
  Dr B Connolly
Applications accepted all year round

Funding Type

PhD Type

Applications are invited for a full time PhD studentship in the Department of Materials at the University of Manchester. The project is supported by BAE Systems, who will provide both industrial supervision, access to research facilities and secondments during the studentship.
  Development of a three dimensional in vitro model of the human cornea to dissect the inflammatory events associated with sight-threatening ocular pathogens
  Dr C Dobson, Dr C Maldonado-Codina, Prof P Morgan
Applications accepted all year round

Funding Type

PhD Type

The presence of microbes at the corneal surface may trigger low grade discomfort through to acute eye infection and permanent loss of vision.
  Do Altered host-microbial interactions promote oral inflammation during ageing?
  Dr J Konkel, Prof A McBain
Applications accepted all year round

Funding Type

PhD Type

As we age, the systems of our bodies become less able to function; rendering people increasingly infirm. Ageing affects our immune system, impeding our ability to both fight infection and maintain tolerance.
  Engineering synthetic ribosomal RNAs (rRNAs) in yeast
  Prof P Cai, Prof D Delneri
Applications accepted all year round

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  (BBSRC DTP) How ecological interactions shape mutation rates to antimicrobial resistance
  Research Group: Ecology and Evolution
  Dr C Knight, Prof A McBain, Dr P Paszek, Dr R Krašovec
Application Deadline: 31 January 2020

Funding Type

PhD Type

The chance that an organism mutates, for instance that a microbe mutates to resist an antibiotic, can depend on that organism’s environment.
  (BBSRC DTP) Quantifying greenhouse gas emissions in agri-ecosystems across multiple scales
  Prof D Johnson, Prof R Bardgett
Application Deadline: 31 January 2020

Funding Type

PhD Type

This exciting project will provide training for careers in sustainable agriculture. The project will develop new understanding of how grazed grassland management practices influence and mitigate greenhouse gas emissions.
  (BBSRC DTP) Using mathematical models to understand the role of the respiratory microbiome in asthma
  Research Group: Molecular Environmental Sciences
  Dr T Gilman, Dr M Muldoon, Prof N Papadopoulos, Prof D Robertson
Application Deadline: 31 January 2020

Funding Type

PhD Type

Most of the cells in the human body are not human. There are rich microbial communities (i.e., microbiota) in our digestive tracts, our respiratory tracts, and on our skin.
  (BBSRC DTP) Developing enhanced production and separation techniques for glycolipid biosurfactants
  Research Group: Sustainable Industrial Engineering
  Dr J Winterburn, Dr P A Martin
Application Deadline: 31 January 2020

Funding Type

PhD Type

Glycolipid biosurfactants are naturally occurring amphiphiles with a range of unique properties including biodegradability and tolerance of a wide range of temperature and pH.
  (BBSRC DTP) Novel antimicrobial discovery using high-throughput pathway assembly and robotics
  Prof E Takano, Prof A Munro, Prof R Breitling
Application Deadline: 31 January 2020

Funding Type

PhD Type

Recent advances in molecular biology, in particular our improved ability to read and (most importantly) write genomic sequences, have led to renewed excitement in the area of genetic engineering, i.e.
  (BBSRC DTP) Functional characterisation of orphan cytochrome P450 enzymes in Mycobacterium tuberculosis
  Prof A Munro, Dr S Hay, Prof D Leys, Prof J Waltho
Application Deadline: 31 January 2020

Funding Type

PhD Type

Mycobacterium tuberculosis (Mtb) poses a major threat to human health worldwide and remains the biggest killer of humans among infectious diseases.
  (BBSRC DTP) Discovery and Editing Pathways to New Antibiotics
  Prof J Micklefield, Prof D Leys, Dr A Green
Application Deadline: 31 January 2020

Funding Type

PhD Type

There is an urgent need for new antibiotics. The majority of antibiotics that are used to treat infectious diseases today are small molecules produced by microorganisms, called natural products, or derivatives thereof.
  (BBSRC DTP) Mechanism of early steps in protein synthesis by cryoEM imaging of supramolecular complexes
  Dr A Roseman, Prof G D Pavitt, Prof C Baldock
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of this project is to understand the mechanism and control of protein synthesis in eukaryotic cells at the molecular level, particularly focused around the role of the eukaryotic translation initiation factors eIF2, eIF5 and eIF2B.
  (BBSRC DTP) Exploring the host-microbiome interactions to promote healthy skin function
  Prof A Nicolaou, Prof A McBain, Prof C A O'Neill, Dr A Kendall
Application Deadline: 31 January 2020

Funding Type

PhD Type

The surface of our skin is an intriguing landscape covered by a diverse population of microorganisms that are collectively known as the cutaneous ‘microbiome’.
  (BBSRC DTP) Development of whole cell biocatalysts for biomass and plastic degradation
  Dr N Dixon, Prof N Scrutton, Dr A Green
Application Deadline: 31 January 2020

Funding Type

PhD Type

Two major societal challenges exist today i) how can we consumable more sustainably and ii) how can we minimise environmental contamination.
  (BBSRC DTP CASE) Intelligent Engineering of Bacterial Genomes
  Prof R Breitling, Prof E Takano
Application Deadline: 31 January 2020

Funding Type

PhD Type

The goal of this project is to establish methodology for the intelligent engineering of biological hosts for the production of high-value drugs and chemicals.
  (BBSRC DTP) Plant-based production of a vaccine against gonorrhoea
  Prof J P Derrick, Dr A Day
Application Deadline: 31 January 2020

Funding Type

PhD Type

The sexually transmitted disease gonorrhoea is caused by the Gram-negative bacterium Neisseria gonorrhoeae. N. gonorrhoeae is a close relative of Neisseria meningitidis, which causes meningococcal meningitis.
  (BBSRC DTP) Tackling the genomic dark matter through system engineering of ncRNAs in yeast
  Prof D Delneri, Prof P Cai
Application Deadline: 31 January 2020

Funding Type

PhD Type

Non-coding RNAs (ncRNAs) are thought as of genomic "dark matter" for which the biological significance has been largely underestimated.
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