Microbiology PhD Projects, Programmes & Scholarships in Manchester

We have 28 Microbiology PhD Projects, Programmes & Scholarships in Manchester

How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

The University of Manchester Department of Physics and Astronomy

This is an interdisciplinary project. It will provide a unique opportunity to obtain training in a wide range of interdisciplinary skills, including protein engineering techniques, protein purification, atomic force microscopy, neutron reflection and scattering as well as molecular dynamics simulations. Read more

Supervisor: Prof J Lu

28 June 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Defining the mechanistic basis of Aspergillus fumigatus and Non-tuberculous mycobacteria coinfection

The University of Manchester Faculty of Biology, Medicine and Health

Respiratory infections caused by bacteria, fungi and viruses are a global cause of death according to the WHO. Respiratory coinfections are on the rise and in general linked with poor patient outcomes. Read more

Supervisors: Dr S Gago, Dr CK Kosmidis, Prof L Tabernero

Year round applications PhD Research Project Self-Funded PhD Students Only

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(University of Manchester - University of Tokyo Dual Award) Diversifying Antitumor Drugs through the Integration of Synthetic Biology and Chemo-enzymatic Approaches

The University of Manchester Department of Chemistry

Ecteinascidin 743 (ET-743, Trabectedin) is a marine-derived natural organic compound approved for the treatment of soft tissue sarcomas. Read more

Supervisors: Prof E Takano, Prof H Oguri

29 April 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Data-driven optimal prediction of bacteria growth

The University of Manchester Department of Mechanical, Aerospace and Civil Engineering

This project is devoted to an AI-based prediction of bacteria growth and its control by antibiotics. In synthetic biology, an improved understanding of bacterial regulatory circuits is required to develop complex biological systems with functionalities beyond existing in nature [1, 2]. Read more

Supervisor: Prof R Breitling

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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The role of Human cytomegalovirus glycoprotein polymorphisms in disease pathogenesis

The University of Manchester Faculty of Biology, Medicine and Health

Human cytomegalovirus (HCMV) produces asymptomatic infection in most immunocompetent individuals but thereafter establishes life-long infection with periodic reactivation and asymptomatic shedding. Read more

Supervisors: Prof P Vallely, Prof P Klapper

Year round applications PhD Research Project Self-Funded PhD Students Only

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Drug repurposing for the treatment of aspergillosis

The University of Manchester Faculty of Biology, Medicine and Health

The mould Aspergillus fumigatus was classified by the WHO as a critical priority pathogen in 2022. It causes a spectrum of invasive, allergic and chronic disease. Read more

Supervisors: Dr CK Kosmidis, Prof D Ashcroft, Dr M Bottery, Dr M Bromley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Dysfunctional antifungal potency of the respiratory mucosa in COPD

The University of Manchester Faculty of Biology, Medicine and Health

Inhalation of Aspergillus fumigatus spores cause >3,000,000 chronic and >200,000 invasive diseases annually worldwide. Invasive aspergillosis carries a 50% mortality rate overall, but mortality rate approaches 100% if diagnosis is delayed or missed and it is >75% in certain cohorts of patients, such as COPD sufferers. Read more

Supervisors: Dr M Bertuzzi, Dr J.H Herbert, Dr S Gago

Year round applications PhD Research Project Self-Funded PhD Students Only

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The impact of nutritional scavenging on host-pathogen interactions, antifungal efficacy and emergence of antifungal resistance

The University of Manchester Faculty of Biology, Medicine and Health

Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more

Supervisors: Dr N.V.R Van Rhijn, Dr M Bromley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Modelling the ecology and evolution of microbial communities

The University of Manchester Faculty of Biology, Medicine and Health

From the human gut to deep-sea sediments, microbial communities – or microbiomes – colonize virtually every habitat on earth. These microbiomes are central to ecosystem functioning and to host health, and therefore it is essential that we understand how and why they change over time. Read more

Supervisors: Dr K Coyte, Dr C Knight

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the genetic basis of immunological overlap between inflammatory diseases

The University of Manchester Faculty of Biology, Medicine and Health

Genetic studies have identified numerous variants within the human genome associated with susceptibility to common complex inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis (UC). Read more

Supervisors: Mr P Martin, Prof S Eyre, Prof A Morris

Year round applications PhD Research Project Self-Funded PhD Students Only

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Viral-surface interactions studied by vibrational sum-frequency spectroscopy

The University of Manchester Department of Materials

The recent COVID-19 pandemic, and in particular fomite transmission of the virus, led to a lot of interest in how viral particles attached to surfaces, their survival times on different materials and how they transferred to hosts. Read more

Supervisors: Dr A Thomas, Dr R Lindsay

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni

The University of Manchester Faculty of Biology, Medicine and Health

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year. Read more

Supervisors: Dr J Cavet, Dr D Linton

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 28 Microbiology PhD Projects, Programmes & Scholarships in Manchester

Microbiology PhD Projects, Programmes & Scholarships in Manchester

We have 28 Microbiology PhD Projects, Programmes & Scholarships in Manchester

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