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Molecular Biology PhD Projects, Programs & Scholarships in Manchester

We have 61 Molecular Biology PhD Projects, Programs & Scholarships in Manchester

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  Role of cutaneous circadian clocks in gating skin repair
  Dr Q-J Meng, Dr M Sherratt
Application Deadline: 31 March 2019
Biological clocks play a key role by temporally controlling the function of whole organisms (including humans) and individual tissues and cells to be aligned with the rhythmic environment.
  Defining the role of UBLylation pathways in the DNA damage response
  Dr C.K Schmidt, Prof A Sharrocks
Application Deadline: 28 February 2019
This 4-year BBSRC Case studentship with AstraZeneca will look at posttranslational modifications with ubiquitin-like proteins (UBLs) within and beyond the DNA damage response (DDR).
  (WIS) How food-borne Listeria monocytogenes overcomes the host defence mechanisms at the single cell level?
  Dr P Paszek, Prof I Roberts
Application Deadline: 28 February 2019
Pathogens have developed intricate ways to overcome the host’s immune system. In this proposal we will study the direct interaction of macrophages with the important food-borne bacterial pathogen Listeria monocytogenes that causes significant human morbidity and mortality.
  (WIS) Determining the role of vascularisation in glomerular development
  Prof R Lennon, Dr R Naylor
Application Deadline: 28 February 2019
The kidney has an essential role in filtering waste and toxins from the blood. When kidney function declines the impact on health is severe.
  (MCRC Non-Clinical) NK cell control of tumour growth dependent on the inflammatory environment
  Prof D Davis, Dr S Zelenay
Application Deadline: 24 February 2019
Arguably, immune therapies for cancer are at a tipping point. Undoubtedly, there are many more successes to come. Understanding the mechanisms behind a strong anti-tumour immune response will surely seed new ideas for immune therapies.
  (WIS) The application of novel Top down Mass Spectrometry to uncover targeted mutagenesis of DNA repair proteins for exposomics
  Dr A Povey, Prof P Barran, Prof G Margison
Application Deadline: 28 February 2019
Next generation sequencing of human tumour DNA consistently shows large numbers of mutations scattered throughout the genome (e.g.
  (WIS) Inhibition of osteoclastogenesis for the prevention of bone wasting in human disease
  Prof J Hoyland, Dr J Bella
Application Deadline: 28 February 2019
Osteoclasts (OCLs) are phagocytic cells that degrade bone as part of its homeostatic regulation. Abnormal activity of OCLs in several pathologies, such as osteoporosis and cancer, results in loss of bone mass, increased risk of fractures, and in an overall increase in significant morbidity and mortality.
  Understanding the role of spliceosome gene mutations in disease
  Dr R O'Keefe, Prof B Newman
Applications accepted all year round
The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made.
  Genetic mechanisms of chronic kidney disease
  Prof M Tomaszewski, Prof A Woolf
Applications accepted all year round
Chronic kidney disease (CKD) is one of the most common complex disorders. The prevalence of CKD is on the rise in all populations around the globe and both the clinical and economic pressures of CKD on the healthcare systems increase exponentially.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round
Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
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