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Molecular Biology PhD Projects, Programs & Scholarships in Manchester

We have 132 Molecular Biology PhD Projects, Programs & Scholarships in Manchester

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  Probing the organization and function of bacterial toxin-antitoxin complexes
  Dr F Hayes, Prof J P Derrick
Applications accepted all year round

Funding Type

PhD Type

Bacterial toxin-antitoxin (TA) modules typically consist of a pair of genes that encode for a stable toxin protein and an unstable cognate antitoxin molecule.
  Development of an in vitro model to dissect the mechanism of fungal persistence in the cystic fibrosis lung
  Prof P Bowyer, Dr M Bromley, Dr S Gago
Application Deadline: 28 February 2020

Funding Type

PhD Type

Cystic fibrosis (CF) is the most common fatal genetically inherited disease in Caucasian populations. This disease is caused by mutations in the cystic fibrosis transmembrane regulator gene (CFTR) which produces defective ion fluxes and calcium homeostasis in the epithelia.
  Nanoparticle conjugates for agricultural disease detection and diagnosis
  Dr L Wong, Prof J Micklefield
Applications accepted all year round

Funding Type

PhD Type

Infectious diseases in plant crops present a significant socioeconomic burden globally, as they compromise the safety and reliability of food supply, as well as other agricultural products.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  Expanding the Genetic Code of a Synthetic Yeast
  Prof P Cai, Dr A Green
Applications accepted all year round

Funding Type

PhD Type

The proposed project aims to develop an efficient yeast-based protein expression platform with an expanded genetic code. The standard genetic code of natural organisms comprises 20 canonical amino acids.
  Human body temperature as a driver of fungal pathogenicity in the lung (Manchester-Melbourne Dual Award)
  Prof E Bignell, Dr M Bromley
Application Deadline: 31 January 2020

Funding Type

PhD Type

Fungal lung diseases are an often fatal consequence of spore inhalation which occur with high prevalence across the globe in settings of immune dysfunction and genetic risk.
  What is the significance of MCT1 distribution to a novel subcellular location (nucleus) for cancer progression?
  Dr A Latif, Prof K Williams, Dr A Hurlstone
Applications accepted all year round

Funding Type

PhD Type

MCT1 is a transmembrane protein involved in cell metabolism and mediates transport of monocarboxylates (such as pyruvate {a metabolic substrate} and lactate {a metabolic by product}) in and out of the cell.
  (A*STAR) Engineering pathways to next generation antibiotics
  Prof J Micklefield, Dr A Green
Application Deadline: 31 January 2020

Funding Type

PhD Type

The provision of new antibiotics to combat antimicrobial resistance (AMR) and to treat neglected tropical diseases (NTD), which are problematic in the developing world, is a major global challenge.
  (A*STAR) Elucidation of molecular footprints of kidney fibrosis through integrative ‘omics’-based analysis
  Prof M Tomaszewski, Dr A Adamson, Prof A Woolf
Application Deadline: 31 January 2020

Funding Type

PhD Type

The fibrosis is a common pathway of structural damage in many kidney diseases. It is usually diagnosed when patients present with an irreversible drop in glomerular filtration rate.
  (A*STAR) The role of desmosome regulation in development, wound healing and cancer
  Dr C Ballestrem, Prof D R Garrod
Application Deadline: 31 January 2020

Funding Type

PhD Type

The regulation of cell movement is a key factor in human development and disease. Desmosomes are intercellular junctions that give strength to normal tissues by binding their cells tightly together.
  (A*STAR) Analysis of the role of microRNAs in the regulation of NF-kappaB dynamics and function
  Prof Mike White, Dr A P Gilmore, Prof S Griffiths-Jones
Application Deadline: 31 January 2020

Funding Type

PhD Type

NF-κB is a key signalling system that controls inflammation and cell fate, dysregulation of which can lead to inflammatory disease or cancer.
  (A*STAR) Investigating Pak2 regulation of extracellular matrix after myocardial infarction
  Dr X Wang, Dr V Liu
Application Deadline: 31 January 2020

Funding Type

PhD Type

Following myocardial infarction (MI), extracellular matrix (ECM) remodelling is critical for acute cardiac tissue healing; however, excessive accumulation of ECM during the chronic stage accelerates the progression to heart failure.
  (A*STAR) Understanding cilia as a complex system: insights from molecular co-evolution
  Dr K Hentges, Dr D Talavera
Application Deadline: 31 January 2020

Funding Type

PhD Type

The cilium is a complex structure built from hundreds of proteins which must function as a single unit within the cell. A particular type of specialised motile cilia are present during development.
  (A*STAR) RNA-based sensors of host-imposed stress in the major fungal pathogen of human lungs: Potential as drug targets
  Prof E Bignell, Prof J Micklefield
Application Deadline: 31 January 2020

Funding Type

PhD Type

The often-fatal fungal lung disease invasive aspergillosis (IA) has claimed more than 8 million human lives since its. emergence ~ 40 years ago.
  (A*STAR) Unravelling the metabolic basis of Aspergillus fumigatus adaptation to combinatorial stress conditions
  Dr J Amich, Prof E Bignell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Aspergillus fumigatus is an environmental saprophytic fungus that lives ubiquitously in the soil. This fungus can also infect the lungs of individuals with any kind of immune imbalance, causing a broad range of diseases collectively termed aspergillosis.
  (A*STAR) Engineering the recognition of antibodies by bacterial superantigens
  Prof J P Derrick, Dr F Hayes
Application Deadline: 31 January 2020

Funding Type

PhD Type

Superantigens are proteins which have the ability to cause hyperactivation of T cells; they are produced by certain bacteria or viruses as a defence mechanism against attack by the immune system.
  Targeting miR-29 in cutaneous wounds
  Dr S Kurinna
Applications accepted all year round

Funding Type

PhD Type

The development of efficient strategies for the improvement of wound repair requires understanding of the mechanisms underlying normal and impaired healing.
  Tackling antibiotic resistance: developing a vaccine against gonorrhoea
  Prof J P Derrick, Dr F Hayes
Applications accepted all year round

Funding Type

PhD Type

Gonorrhoea is caused by the Gram-negative bacterium Neisseria gonorrhoeae and is a serious public health problem in developing and developed countries.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
  Genetic mechanisms of chronic kidney disease
  Prof M Tomaszewski, Prof A Woolf
Applications accepted all year round

Funding Type

PhD Type

Chronic kidney disease (CKD) is one of the most common complex disorders. The prevalence of CKD is on the rise in all populations around the globe and both the clinical and economic pressures of CKD on the healthcare systems increase exponentially.
  Partitioning primary and secondary changes of gene expression caused by gene mutations
  Dr D Talavera, Prof G D Pavitt, Dr J-M Schwartz
Applications accepted all year round

Funding Type

PhD Type

Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein.
  EPSRC CDT in Integrated Catalysis – iCAT

Funding Type

PhD Type

Applications from eligible candidates are invited for fully-funded (fees and stipend) four-year PhD studentships, to integrate the second cohort of the EPSRC CDT in Integrated Catalysis (iCAT CDT) at The University of Manchester, starting in October 2020.
  Understanding differential responses to retinoid treatments in human health and disease: a precision medicine approach
  Prof R Watson, Dr A Langton
Applications accepted all year round

Funding Type

PhD Type

Retinoids, such as all-trans retinoic acid (t-RA), are endogenous signalling molecules derived from vitamin A that influence a variety of cellular processes through mediation of transcription events in the cell nucleus.
  Development of a three dimensional in vitro model of the human cornea to dissect the inflammatory events associated with sight-threatening ocular pathogens
  Dr C Dobson, Dr C Maldonado-Codina, Prof P Morgan
Applications accepted all year round

Funding Type

PhD Type

The presence of microbes at the corneal surface may trigger low grade discomfort through to acute eye infection and permanent loss of vision.
  Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
  Prof S Hubbard, Prof S Griffiths-Jones, Dr M Baron
Applications accepted all year round

Funding Type

PhD Type

Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome.
  The role of the spliceosome protein Prpf8 in embryonic development
  Dr K Hentges
Applications accepted all year round

Funding Type

PhD Type

Errors that occur during cardiac development cause congenital heart defects (CHD). Despite the prevalence of CHD, the developmental processes that ensure the heart forms correctly are still being elucidated.
  (BBSRC DTP CASE) Use of genomic technologies to enhance food safety and authenticity
  Dr M Bromley, Prof P Bower
Application Deadline: 31 January 2020

Funding Type

PhD Type

The annual cost to UK health service due to food related ill health is £6Bn. In addition food fraud is estimated to cost UK business in the region of £11 Bn per annum.
  (BBSRC DTP CASE) Jellyfish-collagen hydrogels for culture and differentiation of human mesenchymal stem cells and 3D cartilage bioprinting
  Dr J Bella, Dr S Richardson, Dr M Domingos
Application Deadline: 31 January 2020

Funding Type

PhD Type

We are looking for an enthusiastic and talented graduate from a relevant biomedical or materials science degree to develop next-generation, sustainable collagen-based scaffolds for stem cell culture, differentiation, and 3D bioprinting, aimed at tissue regeneration applications.
  (BBSRC DTP CASE) Understanding and predicting the immunogenicity of therapeutic protein products
  Prof J P Derrick, Dr R Dearman
Application Deadline: 31 January 2020

Funding Type

PhD Type

Biopharmaceuticals, or therapeutic protein products (TPPs) have been in widespread clinical use for several decades. They comprise a wide range of pharmaceutical products, from vaccines to hormones, cytokines and monoclonal antibodies.
  Engineering synthetic ribosomal RNAs (rRNAs) in yeast
  Prof P Cai, Prof D Delneri
Applications accepted all year round

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
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