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We have 52 Molecular Biology PhD Projects, Programmes & Scholarships in Manchester

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Molecular Biology PhD Projects, Programmes & Scholarships in Manchester

We have 52 Molecular Biology PhD Projects, Programmes & Scholarships in Manchester

University of Salford

PhD programmes at the University of Salford

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Defining the molecular mechanisms of leukaemia chemotherapies

The University of Manchester Faculty of Biology, Medicine and Health
Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more
 Supervisors: Dr JK Knight, Dr K Batta, Dr D Wiseman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the interaction of La related proteins with colliding ribosomes

The University of Manchester Faculty of Biology, Medicine and Health
Translation of mRNA into proteins is a critical cellular biological process for all life. This requires ribosomes to act with an array of translation factors to decode mRNA sequences. Read more
 Supervisors: Prof G D Pavitt, Dr A Roseman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Where has all of the carbon gone? Understanding the molecular mechanisms of long-term soil carbon capture

The University of Manchester Department of Earth and Environmental Sciences
Soils, while unglamorous, form the basis of the terrestrial biosphere and are ultimately the source of the majority of the food that we eat, yet fundamental aspects of how soils form and how they store carbon are poorly understood. Read more
 Supervisors: Prof D Cameron, Dr S Nixon
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Targeting the mechanism of small GTPase splice variant RAC1B using ligand design

The University of Manchester Faculty of Biology, Medicine and Health
RAC1 is a small GTPase protein that functions as a key signalling node downstream of various microenvironmental signalling pathways. Read more
 Supervisors: Dr RB Bryce, Dr S Butterworth, Dr T Jowitt, Dr A Ucar
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

The University of Manchester Faculty of Biology, Medicine and Health
A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more
 Supervisors: Dr R Hager, Dr M Harte, Dr J Glazier
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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What is the interrelationship between cell mitosis and cell polarity during apical-basal polarisation of epithelial organs?

The University of Manchester Faculty of Biology, Medicine and Health
My group strives to uncover how mechanics and biochemical signalling work together to shape epithelial organs during development. Read more
 Supervisors: Dr C.B Buckley, Dr S Woolner
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health
Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more
 Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health
The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more
 Supervisors: Prof R O'Keefe, Prof B Newman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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(University of Manchester - University of Tokyo Dual Award) Diversifying Antitumor Drugs through the Integration of Synthetic Biology and Chemo-enzymatic Approaches

The University of Manchester Department of Chemistry
Ecteinascidin 743 (ET-743, Trabectedin) is a marine-derived natural organic compound approved for the treatment of soft tissue sarcomas. Read more
 Supervisors: Prof E Takano, Prof H Oguri
 29 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Driving phenotypic plasticity and metastasis in small cell lung cancer

The University of Manchester Faculty of Biology, Medicine and Health
Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more
 Supervisors: Prof A Malliri, Dr K Simpson, Prof C Dive
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more
 Supervisors: Prof C M Grant, Prof M Ashe
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Discerning the role of metabolic proteins in nucleus

The University of Manchester Faculty of Biology, Medicine and Health
Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more
 Supervisor: Dr A Latif
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Evaluating the risk of biguanides and statins on cancer incidence and mortality rates: a mixed methods study combining pharmacoepidemiological and experimental approaches

The University of Manchester Faculty of Biology, Medicine and Health
In the UK, every two minutes someone is diagnosed with cancer and every four minutes someone dies from it– leading to more than 360,000 new cases and 160,000 deaths annually1. Read more
 Supervisor: Dr A Latif
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

The University of Manchester Faculty of Biology, Medicine and Health
Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more
 Supervisors: Dr G. Morris, Dr R Wykes, Prof R Baines
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Dysfunctional antifungal potency of the respiratory mucosa in COPD

The University of Manchester Faculty of Biology, Medicine and Health
Inhalation of Aspergillus fumigatus spores cause >3,000,000 chronic and >200,000 invasive diseases annually worldwide. Invasive aspergillosis carries a 50% mortality rate overall, but mortality rate approaches 100% if diagnosis is delayed or missed and it is >75% in certain cohorts of patients, such as COPD sufferers. Read more
 Supervisors: Dr M Bertuzzi, Dr J.H Herbert, Dr S Gago
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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