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We have 17 Molecular Genetics PhD Projects, Programmes & Scholarships in Manchester

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Biological Sciences

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Manchester  United Kingdom

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Molecular Genetics PhD Projects, Programmes & Scholarships in Manchester

We have 17 Molecular Genetics PhD Projects, Programmes & Scholarships in Manchester

Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more

Understanding KANK1 contribution to neuronal health and disease.

Motor Neurone Disease (MND) is a catastrophic disease with a 100% fatality rate but is mechanistically poorly understood. Recently, αβ-integrin heterodimers have been implicated in neurodegeneration. Read more

A novel role in mitochondrial homeostasis for the anti-ageing factor RBBP5

The mitochondrion has evolved from the endosymbiotic interaction of an alpha-proteobacterium and an archaeon. One major event during this evolution was the transferring of genes from the symbiont to the host. Read more

Ecological and evolutionary strain-level dynamics of key pathogens in the cystic fibrosis lung microbiome.

People with cystic fibrosis (pwCF) harbour chronic lung infections caused by a variety of bacterial pathogens. In the CF airway, mucus accumulates in the lungs potentiating the development of a taxonomically diverse lung microbiome. Read more

Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1

RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RAC1-NDD) that results from mutations in the RAC1 gene. Read more

Investigating the impact of antibiotic dose on the distribution of resistance mutations

The antimicrobial resistance crisis poses one of the biggest threats to healthcare systems globally. Tackling this crisis requires better understanding of the factors that contribute to resistance evolution, especially those that can be altered or manipulated to inform treatment. Read more

Comparative investigations into proton and photon radiation in chromosomal instability- and telomere spectrum disorders

Chromosomal instability- and telomere spectrum disorders (CITSDs), such as Bloom syndrome (BS), Fanconi anaemia (FA), or Dyskeratosis Congenita (DKC) are inherited conditions with congenital and developmental abnormalities and impaired ability to maintain chromosomal integrity. Read more

Genetic and acoustic diversity in an invasive parrot

The ring-necked parakeet Psittacula krameri is one of the world’s most successfully introduced species. Native to the Indian sub-continent and sub-Saharan Africa, this species is the UK’s only naturalised parrot, and populations are continuing to increase rapidly across Europe. Read more

Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning

The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more

Delineating the IRF6 regulatory network driving periderm formation and function

During development, the ectoderm passes through a series of cell states to produce a self-replenishing, multi-layered epidermis. Initial stratification forms a single-cell layer of flattened periderm cells which act as a barrier to prevent pathological adhesions during embryogenesis. Read more

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