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Pathology PhD Projects, Programs & Scholarships in Manchester

We have 13 Pathology PhD Projects, Programs & Scholarships in Manchester

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Showing 1 to 13 of 13
  Molecular characterisation of novel interactions of DNA repair proteins
  Dr A Povey, Prof G Margison
Applications accepted all year round

Funding Type

PhD Type

Human exposure to alkylating agents is unavoidable through both exogenous sources and endogenous formation. Some of these compounds have been shown to be toxic and carcinogenic in animal models and some are known human carcinogens.
  Impact of liver reduction diet, low calorie diet and bariatric surgery on hepatic health and cardiometabolic risk factors.
  Dr H Soran, Dr A Syed, Dr R Donn, Dr M Ferdousi
Applications accepted all year round

Funding Type

PhD Type

Obesity and its related co-morbidities, especially Type 2 Diabetes (T2DM), are a major source of disability and premature mortality from micro- and macro-vascular discease.
  Small nerve fibre damage and sexual dysfunction in diabetes and obesity. A mechanistic assessment and effect of lipid modifying agents.
  Dr H Soran, Prof R Malik, Dr R Donn, Dr M Ferdousi
Applications accepted all year round

Funding Type

PhD Type

Diabetes and its complications represent a growing global health burden, affecting an estimated 366 million people worldwide.
  Understanding differential responses to retinoid treatments in human health and disease: a precision medicine approach
  Prof R Watson, Dr A Langton
Applications accepted all year round

Funding Type

PhD Type

Retinoids, such as all-trans retinoic acid (t-RA), are endogenous signalling molecules derived from vitamin A that influence a variety of cellular processes through mediation of transcription events in the cell nucleus.
  Development of a three dimensional in vitro model of the human cornea to dissect the inflammatory events associated with sight-threatening ocular pathogens
  Dr C Dobson, Dr C Maldonado-Codina, Prof P Morgan
Applications accepted all year round

Funding Type

PhD Type

The presence of microbes at the corneal surface may trigger low grade discomfort through to acute eye infection and permanent loss of vision.
  Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
  Dr V Liu, Dr L Swanton
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function.
  The impact of zinc deficiency on Alzheimer’s disease
  Dr C Lawrence, Prof D Brough
Applications accepted all year round

Funding Type

PhD Type

In addition to memory problems, people with Alzheimer’s disease (AD) also experience ‘non-memory’ behavioural symptoms including depression, anxiety, and agitation.
  How do phosphodiesterases contribute to the pathophysiology of heart failure?
  Prof A Trafford, Dr K Dibb
Applications accepted all year round

Funding Type

PhD Type

Heart failure (HF) remains a major cause of death with worse 5-year survival than all forms of cancer combined. This project seeks to understand the mechanisms that underlie two important contributing factors to death in HF patients; i) contractile failure and, ii) the increased propensity for arrhythmias.
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round

Funding Type

PhD Type

Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  Using zebrafish models to investigate cerebral arteriovenous malformations
  Dr P Kasher, Prof S Allan, Dr A Parry-Jones, Dr H Patel
Applications accepted all year round

Funding Type

PhD Type

Cerebral Arteriovenous Malformations (cAVM) relate to a spectrum of conditions associated with blood vessel abnormalities of the brain [1].
  Epigenetic regulation in heart failure and cardiac sudden death
  Dr X Wang, Dr V Liu
Applications accepted all year round

Funding Type

PhD Type

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem.
  Insights into eye disease: understanding the molecular basis of age-related macular degeneration
  Prof T Day, Dr S Clark
Applications accepted all year round

Funding Type

PhD Type

Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]).
  Basal stem cells in the lung and their recognition of dying cells
  Prof T Hussell, Dr N Fujino
Applications accepted all year round

Funding Type

PhD Type

Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown.
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