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Pathology PhD Projects, Programs & Scholarships in Manchester

We have 7 Pathology PhD Projects, Programs & Scholarships in Manchester

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  (MCRC Non-Clinical) NK cell control of tumour growth dependent on the inflammatory environment
  Prof D Davis, Dr S Zelenay
Application Deadline: 24 February 2019
Arguably, immune therapies for cancer are at a tipping point. Undoubtedly, there are many more successes to come. Understanding the mechanisms behind a strong anti-tumour immune response will surely seed new ideas for immune therapies.
  (WIS) Inhibition of osteoclastogenesis for the prevention of bone wasting in human disease
  Prof J Hoyland, Dr J Bella
Application Deadline: 28 February 2019
Osteoclasts (OCLs) are phagocytic cells that degrade bone as part of its homeostatic regulation. Abnormal activity of OCLs in several pathologies, such as osteoporosis and cancer, results in loss of bone mass, increased risk of fractures, and in an overall increase in significant morbidity and mortality.
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  Using zebrafish models to investigate cerebral arteriovenous malformations
  Dr P Kasher, Prof S Allan, Dr A Parry-Jones, Dr H Patel
Applications accepted all year round
Cerebral Arteriovenous Malformations (cAVM) relate to a spectrum of conditions associated with blood vessel abnormalities of the brain [1].
  Epigenetic regulation in heart failure and cardiac sudden death
  Dr X Wang, Dr V Liu
Applications accepted all year round
A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem.
  Insights into eye disease: understanding the molecular basis of age-related macular degeneration
  Prof T Day, Dr S Clark
Applications accepted all year round
Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]).
  Basal stem cells in the lung and their recognition of dying cells
  Prof T Hussell, Dr N Fujino
Applications accepted all year round
Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown.
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