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We have 16 Pathology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Manchester
Pathology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Manchester
We have 16 Pathology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Manchester
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Infrared (IR) spectroscopic imaging and digital pathology for development of algorithms for early detection of test-article related lung findings in the Han Wistar rats.
Digital pathology lends itself to the systematic use of artificial intelligence applications. Algorithms developed with machine learning on scanned images are objective, accurate and can produce results more quickly than pathologists. Read more
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Using functional Magnetic Resonance Imaging (MRI) to investigate the neuronal and muscular impacts of Long COVID: improving diagnostics for delineating distinct disease subgroups.
An opportunity to complete a three-year funded PhD in Neuroscience hosted by the . Institute of Sport. at Manchester Metropolitan University. . Read more
Epigenetic regulation in heart failure and cardiac sudden death
A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more
Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist. Read more
Using zebrafish models to investigate cerebral arteriovenous malformations
Cerebral Arteriovenous Malformations (cAVM) relate to a spectrum of conditions associated with blood vessel abnormalities of the brain [1]. Read more
The impact of zinc deficiency on Alzheimers disease
In addition to memory problems, people with Alzheimer’s disease (AD) also experience ‘non-memory’ behavioural symptoms including depression, anxiety, and agitation. Read more
Basal stem cells in the lung and their recognition of dying cells
Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown. Read more
Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more
Investigating the cardio-pulmonary impact of airborne nanoplastics
There is growing evidence that humans are exposed to incidental microplastics and nanoplastics (MNPL) particles through inhalation and that the small size of these particles may allow for bioaccumulation and retention in the body. Read more
Development of deep learning methods and software to infer pathway enrichment from histology images - application to liver fibrosis
Histopathological images are routinely used to characterize complex phenotypes. For example, pathologists regularly study stained images of tissue biopsies for cancer diagnosis as cancer is known to change the morphological features of cells including cell shape and size [1]. Read more
Defining the pre-metastatic niche for colorectal cancer dissemination
Colorectal cancer is a major cause of mortality and commonly associated with peritoneal metastasis. However, peritoneum, that covers visceral organs and inner cavity wall, is poorly characterised in terms of its ability to act as a metastatic niche. Read more
Virus pathogenesis: interplay between the unfolded protein response and innate immunity.
The unfolded protein response (UPR) is a cellular homeostatic response in restoring endoplasmic reticulum balance upon stress conditions e.g. Read more
Breaking bad: Evolution by loss-of-function
Paradoxically, the first step adaptation to a new environment often involves losing genes, rather than gaining new ones—a phenomenon observed across the tree of life. Read more
Selective drug uptake by cell surface transporters
Cell surface transporters and not diffusion is responsible for the transfer of metabolites across a cell’s membrane. Many types of drugs are structurally very similar to natural metabolites and as a consequence they are treated by the cell as though they are the natural homologue. Read more
Investigating the role of bioactive lipids in skin health
Human skin depends on systemic provision of fatty acids that are important to maintain the integrity of the epidermal barrier as well as to support the associated immune and inflammatory reactions. Read more
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