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Login with FacebookPharmaceutical / Medicinal Chemistry PhD Projects, Programs & Scholarships in Manchester
We have 14 Pharmaceutical / Medicinal Chemistry PhD Projects, Programs & Scholarships in Manchester
We have 14 Pharmaceutical / Medicinal Chemistry PhD Projects, Programs & Scholarships in Manchester
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(BBSRC DTP) Exploring the host-microbiome interactions to promote healthy skin function
The surface of our skin is an intriguing landscape covered by a diverse population of microorganisms that are collectively known as the cutaneous ‘microbiome’. … Read more
(MRC DTP iCASE) Exploring the role of bioactive lipids in cell death pathways underpinning inflammatory skin disease
Cell death pathways such as apoptosis, necroptosis or ferroptosis, are critical for controlling immune responses, deleting self-reactive immune cells, and killing infected and cancer cells. Read more
(BBSRC DTP CASE) Enzymatic methods for assembly of nucleic acid therapeutic agents
Modified nucleic acids have emerged as a powerful new class of therapeutic agents for the prevention and treatment of a range of diseases (e.g. Read more
(MRC DTP) Integrating computational chemistry models of ion channels to build a holistic cardiac safety prediction tool for drug discovery
Ensuring that any potential new medicine does not cause harmful arrhythmias has long been a great challenge. The major cause of this is the ability of many compounds to interfere with ion channels that are crucial to the heart’s regular beat. Read more
(BBSRC DTP) Deciphering the cellular function of the ubiquitin specific protease, USP9x
The de-ubiquitinating enzyme, Ubiquitin Specific Protease 9x (USP9x), is a key protein that regulates a number of important cellular processes including apoptosis, stem cell self-renewal and cell polarity. Read more
(BBSRC DTP) Bioengineering sustainable routes to anti-infective agents to combat AMR and future pandemics
There is an urgent need for new anti-infective agents to combat antimicrobial resistance and to protect the global population in the event of future pandemics. Read more
(BBSRC DTP) Evaluating and modelling glycosaminoglycan fragment interactions with COVID-19
Oligosaccharides are ubiquitous biomolecules on cell surfaces and the intra-cellular matrix, and are central to many critical biological regulatory processes, including cell-differentiation, cancer, bacterial and viral infections and inflammation. Read more
Design, Synthesis and Biological Evaluation of Novel Analogues of the Bioactive Natural Products, Incarviditone and Incarvilleatone
The polyclic natural products incarviditone and incarvilleatone have recently attracted attention due to their synthetically challenging structures as well as their interesting biological properties. Read more
Designing phosphatase inhibitors using novel quantum mechanical calculations.
Phosphatases play important regulatory roles in biochemical pathways that have been linked to a range of human diseases, including. Read more
The chemistry and biophysics of phosphoryl transfer enzymes
One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates. Read more
A step change in the modelling of enzymatic catalysis
A deep understanding of enzymatic processes requires an atomic-level description, which is often beyond experimental techniques but achievable through synergy with computational chemistry. Read more
Polmorphisms in cytosolic drug metabolising enzymes: a combined proteomics and modelling approach to clinical impact
Cytosolic drug metabolising enzymes such as aldehyde oxidase play a pivotal role in metabolism of drugs. However, research into cytosolic enzymes has been relatively neglected in comparison with membrane bound enzymes such as cytochrome P450 (CYP) and uridine 5’-glucuronosyltransferases (UGTs). Read more
Investigation of volatile signalling molecules from interactions between Staphylococcus aureus and Candida albicans in lung infection
Staphylococcus aureus and Candida albicans are commensal microbes which can become pathogenic and cause serious illness, especially in hospitalised patients. Read more
Control of protein self assembly by biological ions
In addition to being an energy source in biological reactions, recent discoveries suggest adenosine triphosphate (ATP) also plays a critical role in maintaining cell stability and preventing deleterious cellular processes through modulating biomacromolecular self assembly. Read more
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