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Pharmaceutical / Medicinal Chemistry PhD Projects, Programs & Scholarships in Manchester

We have 15 Pharmaceutical / Medicinal Chemistry PhD Projects, Programs & Scholarships in Manchester

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Showing 1 to 10 of 15
  (BBRSC DTP CASE) Controlling interfacial adsorption of bispecific therapeutics using multivalent ions
  Dr R Curtis, Dr A Pluen, Dr C F Blanford
Application Deadline: 31 January 2020

Funding Type

PhD Type

ImmTAC molecules are a promising new class of bispecific therapeutics produced by Immunocore for applications in oncology and as new treatments for infectious diseases.
  (BBSRC DTP) Discovery and Editing Pathways to New Antibiotics
  Prof J Micklefield, Prof D Leys, Dr A Green
Application Deadline: 31 January 2020

Funding Type

PhD Type

There is an urgent need for new antibiotics. The majority of antibiotics that are used to treat infectious diseases today are small molecules produced by microorganisms, called natural products, or derivatives thereof.
  (BBSRC DTP) Exploring the host-microbiome interactions to promote healthy skin function
  Prof A Nicolaou, Prof A McBain, Prof C A O'Neill, Dr A Kendall
Application Deadline: 31 January 2020

Funding Type

PhD Type

The surface of our skin is an intriguing landscape covered by a diverse population of microorganisms that are collectively known as the cutaneous ‘microbiome’.
  (BBSRC DTP CASE) Exploitation of P450 BM3 variants for production of valuable drug metabolites
  Prof A Munro, Prof D Leys
Application Deadline: 31 January 2020

Funding Type

PhD Type

The US Food and Drug Administration (FDA) have recommended that human drug metabolites (as well as their parent drugs) should be subject to testing for safety/toxicity.
  (BBSRC DTP CASE) Discovery and Engineering of Expanded Halogenases for Late Stage Enzymatic Functionalisation
  Prof J Micklefield, Prof P Barran
Application Deadline: 31 January 2020

Funding Type

PhD Type

The project aims to discover and engineer novel enzymes (biocatalysts) that can affect regioselective halogenation of complex molecules enabling more efficient and environmentally sustainable production of pharmaceuticals which are urgently required to combat disease.
  Accurate energy evaluation of receptor-ligand interaction
  Prof P Popelier, Dr S De Visser
Applications accepted all year round

Funding Type

PhD Type

Drug design routinely uses existing computational methods to evaluate the interaction energy between receptor (protein) and ligand (drug) in molecular docking.
  A step change in the modelling of enzymatic catalysis
  Prof P Popelier, Dr L Johannissen
Applications accepted all year round

Funding Type

PhD Type

A deep understanding of enzymatic processes requires an atomic-level description, which is often beyond experimental techniques but achievable through synergy with computational chemistry.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  The chemistry and biophysics of phosphoryl transfer enzymes
  Prof J Waltho, Dr A Almond
Applications accepted all year round

Funding Type

PhD Type

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates.
  Assessing the Behaviour of Endotoxin in Biopharmaceutical Formulations: towards creating improved medicines
  Dr A Golovanov
Application Deadline: 15 November 2019

Funding Type

PhD Type

Supervisors. Dr Alexander Golovanov (The University of Manchester) and Dr Adrian Podmore (AstraZeneca). Biopharmaceuticals are the fastest-growing type of treatments for wide range of diseases, with enormous potential for personalised medicine.
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