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Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Manchester

We have 16 Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Manchester

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Showing 1 to 10 of 16
  Role of cutaneous circadian clocks in gating skin repair
  Dr Q-J Meng, Dr M Sherratt
Application Deadline: 31 March 2019
Biological clocks play a key role by temporally controlling the function of whole organisms (including humans) and individual tissues and cells to be aligned with the rhythmic environment.
  In vitro assessment of drug sequestration into lysosomes and in silico prediction of implications for drug disposition and therapeutic efficacy
  Dr A Galetin, Dr D Hallifax
Applications accepted all year round
Intracellular concentration of a drug is an important determinant of its efficacy, toxicity, and potential drug-drug interactions [1].
  Is there a switch between prostamides and prostaglandins in women with dysmenorrhoea and heavy menstrual bleeding?
  Prof K Marshall, Dr D Fischer, Prof A Nicolaou
Applications accepted all year round
Dysmenorrhoea, painful menstrual cramps, and heavy menstrual bleeding are common debilitating symptoms in women with or without an underlying pelvic pathology.
  Structure based design of novel warheads for use in peptide-drug conjugates
  Dr S Butterworth, Dr A Tirella, Dr D Wiseman
Applications accepted all year round
Chronic Myelomonocytic Leukaemia (CMML) is an orphan disease defined by myeloid dysplasia, myeloproliferation and a malignant expansion of classical monocytes.
  Developing preclinical models for cancer therapeutics using biomaterials and omics technologies
  Prof A Nicolaou, Dr A Tirella
Applications accepted all year round
Hydrogels are biomaterials used to prepare in vitro models used to study many biological processes. These materials can be selectively modified to present different physical, chemical and mechanical properties to mimic the ones of the extracellular matrix present in different tissues.
  Exploring the influence of treatment on CD4+ T-cell sub-populations in patients receiving biologic drugs for their inflammatory arthritis
  Prof A Barton, Dr D Plant, Dr S Viatte
Applications accepted all year round
Background. Tumour necrosis factor inhibitor (TNFi) therapy is ineffective for approximately 20% of rheumatoid arthritis (RA) patients and there is currently no way to predict which patients will not benefit.
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  Control of Parathyroid Hormone Secretion
  Dr D Ward, Dr J Bruce
Applications accepted all year round
The regulation of parathyroid hormone (PTH) secretion is of fundamental importance for calcium homeostasis and in mineral conditions affecting bone and the kidneys.
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