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We have 22 Pharmacology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Manchester
Pharmacology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Manchester
We have 22 Pharmacology PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Manchester
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Linking activity to zonal abundance for renal transporter to simulate local drug concentrations in proximal tubule
Prediction of in vivo renal excretion clearance is important to predict the first in human dose, systemic clearance, renal drug-drug interaction, and drug concentration in kidney epithelial cells. Read more
Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain. Read more
The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection
A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more
Adults with Juvenile Idiopathic Arthritis (JIA): the impact of a long-term chronic disease on ongoing arthritis, quality of life, and mental health
Understanding how juvenile idiopathic arthritis (JIA), the most common chronic inflammatory musculoskeletal disease in children and young people, affects later adult-life has been prioritised by individuals living with JIA/families, European arthritis organisations, and charities. Read more
Modulation of the Hippo signalling pathway to enhance cardiac regenerative capacity
Common heart diseases such as heart failure (HF) and coronary heart disease (CHD) are characterized by cardiomyocyte loss due to necrosis and apoptosis. Read more
Infrared (IR) spectroscopic imaging and digital pathology for development of algorithms for early detection of test-article related lung findings in the Han Wistar rats.
Digital pathology lends itself to the systematic use of artificial intelligence applications. Algorithms developed with machine learning on scanned images are objective, accurate and can produce results more quickly than pathologists. Read more
(EPSRC DTP) Capturing images projected on the retina in freely moving animals to understand visuomotor transformations in real life conditions
NATURE & SCOPE. Most of what we know about how the brain process visual information comes from studies in which animals are immobilised. Read more
(EPSRC DTP) Investigating the biological impact of PLA nanoplastics interacting with environmental pollutant
Non-biodegradable plastics that fragment under environmental conditions into incidental micro/nano plastics (MNPLs), are ubiquitous in the environment. Read more
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(MRC DTP CASE) Prediction of opioid-related adverse events using multi-outcome prediction modelling & machine learning
Opioids are commonly used in the management of acute and chronic pain, but prescriptions have escalated leading to an opioid epidemic in several high-income countries. Read more
Identification of mechanisms underlying atrial fibrillation and effective therapies
Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice with particular high prevalence in aged populations. Read more
Effect of vitamin D in vascular and endocrine cells
Vitamin D3 deficiency is a common public health problem worldwide that is increasingly believed to contribute not only to decreased bone mineralisation but potentially to other serious medical conditions. Read more
Using synthetic biology to understand the evolution of antibiotic resistance
Imagine an architect, tasked with converting an old stadium into a building with a different function, without demolishing it. Read more
Investigating the cardio-pulmonary impact of airborne nanoplastics
There is growing evidence that humans are exposed to incidental microplastics and nanoplastics (MNPL) particles through inhalation and that the small size of these particles may allow for bioaccumulation and retention in the body. Read more
Control of Parathyroid Hormone Secretion
The regulation of parathyroid hormone (PTH) secretion is of fundamental importance for calcium homeostasis and in mineral conditions affecting bone and the kidneys. Read more
Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist. Read more
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