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Structural Biology PhD Projects, Programs & Scholarships in Manchester

We have 33 Structural Biology PhD Projects, Programs & Scholarships in Manchester

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We have 33 Structural Biology PhD Projects, Programs & Scholarships in Manchester

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Ion channel clustering in neuronal membranes

The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions. Read more

Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. Read more

The mechanism of regulation of protein synthesis via eIF2 molecular complexes

Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2]. Read more

The chemistry and biophysics of phosphoryl transfer enzymes

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates. Read more

Method development and applications of Electron Paramagnetic Resonance (EPR)

Electron Paramagnetic Resonance (EPR) is a spectroscopic tool used to study systems containing unpaired electrons. EPR has wide ranging applications from materials science and quantum computing to structural biology and (bio)catalysis. Read more

(BBSRC DTP) Mechanism of early steps in protein synthesis by cryoEM imaging of supramolecular complexes

The aim of this project is to understand the mechanism and control of protein synthesis in eukaryotic cells at the molecular level, particularly focused around the role of the eukaryotic translation initiation factors eIF2, eIF5 and eIF2B [1,2]. Read more

(BBSRC DTP) The evolution of odorant receptors in the domestication of Aedes mosquitoes: the link to zoonotic disease emergence

Manmade environmental change has triggered adaptation to domestic habitats in several pest species, including mosquitoes. As well as being of fundamental biological interest, the evolutionary process of domestication also results in the transmission of formerly zoonotic diseases of wildlife to livestock and humans. Read more

Understanding the function and functional mechanism of mitochondrial AAA proteinases

The mitochondrion is a vitally important organelle of eukaryotic cells. Mitochondrial AAA proteinases play important roles in mitochondrial function and protein homeostasis (proteostasis) by removal of unwanted proteins and regulating the function of mitochondrial proteins. Read more

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