Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
Understanding the similarity between the sequence and/or structure of biomolecules has been key to inferring evolutionary relationships and predicting the function of biomolecules.
The concept of the CTD code that specifies the position of RNAPII in the transcriptional cycle and thus recruits specific processing factors, was suggested almost a decade ago.
The novel forms of nucleotide moieties will be incorporated in oligomers with sequences relevant for biosystems. The compatibility of such artificial building blocks will be evaluated using advanced methods of quantum chemistry that provide also analytical tool for investigation of crucial noncovalent interactions.
Detailed molecular characterisation of the tumor or of patient predisposition in cases of hereditary forms of disease is a state of the art approach for high risk cancer patients’ diagnosis and treatment prognosis.
Gastroesophageal reflux is the most common upper gastrointestinal tract disorder that is highly prevalent worldwide with a prevalence of 10%-20% in the western world.
Clinical diagnostics of selected diseases requires analysis of multicomponent mixtures of analytes that is often difficult to accomplish by conventional methods approved for clinical practice.
Food production mostly relies on a proper sexual plant reproduction. Therefore research in fundamental aspects of seed development is crucial to the understanding of processes involved in seed viability.
The SMC (Structure Maintenance of Chromosome) complexes are the key components of higher-order chromatin fibers and play important roles in genome stability.
