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Masaryk University PhD Projects, Programs & Scholarships

We have 42 Masaryk University PhD Projects, Programs & Scholarships

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  A structural basis for the cross-talk between histones and RNA Polymerase II
  Prof R Stefl, Dr K Kubicek, Prof S Vanacova
Application Deadline: 3 February 2019
Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
  Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis
  Dr D Blažek, Prof Z Zdrahal
Application Deadline: 3 February 2019
Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
  Characterizing sequence-structure-function relationships: A multi-dimensional approach for evaluating similarity in structural biology data
  Prof J Koca, Dr C M Ionescu
Application Deadline: 3 February 2019
Understanding the similarity between the sequence and/or structure of biomolecules has been key to inferring evolutionary relationships and predicting the function of biomolecules.
  Cracking the CTD code
  Prof R Stefl, Dr K Kubicek, Dr P Plevka
Application Deadline: 3 February 2019
The concept of the CTD code that specifies the position of RNAPII in the transcriptional cycle and thus recruits specific processing factors, was suggested almost a decade ago.
  Designing modified DNA fragments
  Prof R Marek
Application Deadline: 3 February 2019
The novel forms of nucleotide moieties will be incorporated in oligomers with sequences relevant for biosystems. The compatibility of such artificial building blocks will be evaluated using advanced methods of quantum chemistry that provide also analytical tool for investigation of crucial noncovalent interactions.
  Detailed genomic variant analysis for cancer patient stratification and treatment prognosis
  Dr V Bystrý
Application Deadline: 15 March 2019
Detailed molecular characterisation of the tumor or of patient predisposition in cases of hereditary forms of disease is a state of the art approach for high risk cancer patients’ diagnosis and treatment prognosis.
  Development of capillary electrophoresis methods for non-invasive diagnostics of gastroesophageal reflux disease
  Prof P Kuban, Dr F Foret
Application Deadline: 3 February 2019
Gastroesophageal reflux is the most common upper gastrointestinal tract disorder that is highly prevalent worldwide with a prevalence of 10%-20% in the western world.
  Development of portable capillary electrophoresis instrumentation for medical diagnostic purposes
  Prof P Kuban, Dr F Foret
Application Deadline: 15 March 2019
Clinical diagnostics of selected diseases requires analysis of multicomponent mixtures of analytes that is often difficult to accomplish by conventional methods approved for clinical practice.
  Developmental response induced by abiotic stress during seed development in Brassica sp.
  Dr H.S Robert Boisivon
Application Deadline: 3 February 2019
Food production mostly relies on a proper sexual plant reproduction. Therefore research in fundamental aspects of seed development is crucial to the understanding of processes involved in seed viability.
  Dynamics of the Structure Maintenance of Chromosome (SMC) complexes
  Prof J Fajkus, Prof J Palecek
Application Deadline: 3 February 2019
The SMC (Structure Maintenance of Chromosome) complexes are the key components of higher-order chromatin fibers and play important roles in genome stability.
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