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Medical / Clinical Science (genes) PhD Projects, Programs & Scholarships

We have 61 Medical / Clinical Science (genes) PhD Projects, Programs & Scholarships

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  Gene Regulation: How mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases
  Prof D Higgs, Assoc Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 26 July 2019

Funding Type

PhD Type

Other Potential Supervisors. Mira Kassouf. Our laboratory addresses the question of how mammalian genes are switched on and off during development, lineage commitment and differentiation.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Investigating the candidate genes that alter body fat distribution using a big data analysis and CRISPR-Cas9 gene editing
  Dr A Oguro-Ando
Application Deadline: 27 May 2019

Funding Type

PhD Type

Lead supervisor. Dr Asami Oguro-Ando, College of Medicine and Health, University of Exeter. Additional supervisors. Prof Tim Frayling, College of Medicine and Health, University of Exeter.
  Genetic Epidemiology of Cardiovascular Disease: Studying genetic variation in cardiomyopathy and coronary artery disease across the entire allele frequency spectrum in order to identify causative genes and susceptibility loci.
  Prof M Farrall, Dr AG Goel
Application Deadline: 26 July 2019

Funding Type

PhD Type

Studying genetic variation in cardiomyopathy and coronary artery disease across the entire allele frequency spectrum in order to identify causative genes and susceptibility loci.
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Functional coronary artery disease genetics: investigating the role of the candidate gene in models of In vivo cardiovascular disease
  Dr G Douglas, Prof K Channon
Application Deadline: 26 July 2019

Funding Type

PhD Type

Despite significant advancements in its treatment coronary artery disease is the leading cause of death in both the UK and world wide, accounting for over 66,000 deaths in the UK each year.
  Investigating convergent pathways regulating pancreatic and brain development in humans.
  Dr A Bhinge
Application Deadline: 27 May 2019

Funding Type

PhD Type

Lead supervisor. Dr Akshay Bhinge, College of Medicine and Health, University of Exeter. Additional supervisors. Professor Andrew Hattersley, College of Medicine and Health, University of Exeter.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  Understanding the role of HoxA9 in chemotherapy resistance of Acute Myeloid Leukaemia (AML)
  Dr M Esposito
Applications accepted all year round

Funding Type

PhD Type

Acute Myeloid Leukaemia (AML) is a rare but yet deadly form of blood cancer. Genome-wide expression arrays and RNA sequencing have contributed to unravelling the leukaemia signature genes.
  Clinical Genetics: De Novo Mutations, Selfish Selection, Mosaicism and Human Disease - developing methods for identification of new genes/molecular pathways subject to selfish selection within the human testis
  Prof A Goriely, Prof A Wilkie
Application Deadline: 26 July 2019

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
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