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We have 6 Other (inhibitor) PhD Projects, Programmes & Scholarships

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Other (inhibitor) PhD Projects, Programmes & Scholarships

We have 6 Other (inhibitor) PhD Projects, Programmes & Scholarships

Preclinical testing of collagen synthesis inhibitors for fibrotic disease

Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more

Selective targeting of furin for the treatment of fibrotic lung disease.

Furin, a proprotein convertase has been established as a therapeutic target across several disease areas to include chronic airways diseases and infectious disease, such as COVID-19 (reviewed in our recent publication, Douglas et al, 2023). Read more

Use of a novel conjugation approach to generate a long-acting growth hormone receptor antagonist

Targeting the growth hormone (GH) signalling pathway could be an effective therapeutic approach for certain types of cancer. However, a lack of access to therapeutics that target GH or the GH receptor has hindered preclinical studies in this field. Read more

Obtaining an integrated understanding of oncogenic RAS signalling

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more
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