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Medical / Clinical Science (transgenic) PhD Projects, Programs & Scholarships

We have 8 Medical / Clinical Science (transgenic) PhD Projects, Programs & Scholarships

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  RVC PhD: Rebalancing mitochondrial metabolism in Duchenne Muscular Dystrophy - a novel therapeutic avenue?
  Dr C Thornton, Prof D Wells
Application Deadline: 9 February 2020

Funding Type

PhD Type

Duchenne muscular dystrophy (DMD) is a fatal X-linked muscle wasting disease caused by mutations in the DMD gene that lead to the loss of a functional version of the subsarcolemmal protein dystrophin.
  The effect of anaesthetic neurotoxicity on the development of adult neural stem cells
  Dr D Berg, Dr E Kang
Application Deadline: 13 March 2020

Funding Type

PhD Type

Although most neurons in the mammalian brain are generated during development, certain areas possess the capacity to generate new neurons throughout life.
  Egr2 and 3 mediated T cell tolerance in cancer and their impact in immune checkpoint therapy
  Dr S Li
Applications accepted all year round

Funding Type

PhD Type

Tumour infiltrated lymphocytes (TILs) contain tumour reactive T cells and have been used as adoptive cell transfer therapy in patients which can mediate cancer regression.
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  The Hippo pathway and Yap1 in vascular growth control in development and disease
  Prof B Hogan, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Lymphatic vessels play roles in the drainage of tissue fluid, trafficking of immune cells and the metastatic spread of cancer.
  Targeting mRNA polyadenylation as novel treatment strategy in epilepsy
  Dr T Engel, Dr J Lucas
Applications accepted all year round

Funding Type

PhD Type

Epileptogenesis, the process leading to a reduced threshold for seizures after transient brain insults, is associated with large-scale changes in gene expression and processes, such as selective neuronal loss, gliosis and synaptic plasticity which ultimately lead to the formation of seizuregenerating neuronal networks, and the development of epilepsy.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round

Funding Type

PhD Type

The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Identification of key factors from adipose tissue that mediate obesity-induced diabetes and cardiovascular complications
  Prof A Xu
Applications accepted all year round

Funding Type

PhD Type

Adipose tissue (fat) is a highly heterogeneous and dynamic organ that plays integral roles in metabolic and cardiovascular health.
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