RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RRND) that results from mutations in the RAC1 gene. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Blood/immune cells sustain life through oxygen supply, resistance to infection, and gatekeeping cancer cells. We developed a powerful stem cell culture system that allowed us to recapitulate blood/immune cell development in human organoids. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project has funding attached, subject to eligibility criteria. Applications for the project are welcome from all suitably qualified candidates, but its funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.
Adult multipotent stem cells can be easily isolated from a variety of adult human tissues and organs including bone marrow and adipose tissue. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells) are pluripotent and thus hold great promise in regenerative medicine, studying disease mechanisms and drug discovery. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project has funding attached, subject to eligibility criteria. Applications for the project are welcome from all suitably qualified candidates, but its funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.
The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
The immune system must be primed to quickly respond to infection, but must also be tightly regulated so it ignores harmless substances and our own tissues. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
This project is available through the MIBTP programme on a competition basis. The successful applicant will join the MIBTP cohort and will take part in all of the training offered by the programme. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project is in competition for funding with other projects. Usually the project which receives the best applicant will be successful. Unsuccessful projects may still go ahead as self-funded opportunities. Applications for the project are welcome from all suitably qualified candidates, but potential funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Rab27 small GTPases regulate movement and exocytosis of secretory granules in cell types including; melanocytes (melanosomes), T lymphocytes (lytic granules), granulocytes (azurophilic granules) and mast cells [1]. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Cardiac fibrosis is a hallmark histological feature of structural changes in the myocardium associated with virtually all cardiac diseases (e.g., heart failure, hypertension, atrial fibrillation and myocarditis). Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Application accepted for either MSc by Research or PhD. The urothelium is the self-regenerating epithelium that lines the bladder, where it is highly specialised to function as a urinary barrier. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
The regulation of parathyroid hormone (PTH) secretion is of fundamental importance for calcium homeostasis and in mineral conditions affecting bone and the kidneys. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Defining the function of new causal atherosclerosis genes from CAD GWAS loci using in vitro and in vivo models Despite significant advancements in its treatment coronary artery disease is the leading cause of death in both the UK and world wide, accounting for over 66,000 deaths in the UK each year. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Vitamin D3 deficiency is a common public health problem worldwide that is increasingly believed to contribute not only to decreased bone mineralisation but potentially to other serious medical conditions. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
The Academic Endocrine Unit investigates the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Our work focuses on understanding how obesity drives the development of type 2 diabetes and cardiovascular disease. Specifically, it aims to decipher molecular determinants of adipocyte number and distribution within the body; key factors of susceptibility to obesity-associated cardiometabolic diseases. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project is in competition for funding with other projects. Usually the project which receives the best applicant will be successful. Unsuccessful projects may still go ahead as self-funded opportunities. Applications for the project are welcome from all suitably qualified candidates, but potential funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project is in competition for funding with other projects. Usually the project which receives the best applicant will be successful. Unsuccessful projects may still go ahead as self-funded opportunities. Applications for the project are welcome from all suitably qualified candidates, but potential funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.
Musculoskeletal interfaces are the areas of the body where tissue types meet, for example the bone-tendon, bone-cartilage and muscle-tendon junctions. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Work in the Lowe laboratory is aimed at deciphering the molecular mechanisms that control membrane trafficking within cells. A major focus of our work is the trafficking of proteins to and through the Golgi apparatus, which lies at the heart of the secretory pathway. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Multidrug resistance renders chemotherapeutic treatment failure in large proportion of head and neck squamous cell carcinoma (HNSCC) patients requiring multimodal therapy involving chemotherapy in conjunction with surgery and/or radiotherapy. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
The laboratory of Dr. Shih-Chieh Ti in the School of Biomedical Sciences at the University of Hong Kong (https://www.sbms.hku.hk/) seeks enthusiastic and self-motivated Ph.D. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project has funding attached, subject to eligibility criteria. Applications for the project are welcome from all suitably qualified candidates, but its funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.
Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Inflammasomes are multi-protein complexes which are crucial for initiating immune responses, and are required for activating key cytokines such as IL-1 beta. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Research Group:
Pharmacology and Experimental Therapeutics
Sarcopenia is a significant health condition in relation to ageing affecting ~25% of older people. Sarcopenia presents with low muscle mass and strength, and a decline in muscle quality, which substantively decreases quality of life. Current treatment is ineffective and there is currently a lack of biomarkers for sarcopenia. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This research project has funding attached. It is only available to UK citizens or those who have been resident in the UK for a period of 3 years or more. Some projects, which are funded by charities or by the universities themselves may have more stringent restrictions.
Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.
Ovarian cancer is a leading cause of cancer death in women. Identification of novel, actionable and effective strategies to treat the disease could significantly contribute to the improvement of patient survival. Read more
PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.
This project has funding attached, subject to eligibility criteria. Applications for the project are welcome from all suitably qualified candidates, but its funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.