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Medical / Clinical Science (cell culture) PhD Projects, Programs & Scholarships

We have 115 Medical / Clinical Science (cell culture) PhD Projects, Programs & Scholarships

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Showing 1 to 30 of 115
  Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1
  Dr T Millard, Dr S Banka
Applications accepted all year round

Funding Type

PhD Type

RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RRND) that results from mutations in the RAC1 gene.
  Dynamic cell fate decisions: linking mechanical signals and protein expression dynamics in the developing eye to understand human developmental disorders
  Dr Cerys Manning, Prof N Papalopulu
Applications accepted all year round

Funding Type

PhD Type

Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation.
  Investigating metabolic changes in neurodegeneration
  Dr F Mackenzie, Dr M Stolinski
Applications accepted all year round

Funding Type

PhD Type

This 3-year PhD will study the increasingly recognised association between metabolic disease and neurodegeneration using in vitro cell culture methods.
  Impact of Inflammatory Signals on the Regenerative, Anti-inflammatory and Immunomodulatory Potential of Human Mesenchymal Stem Cells and their Secretome
  Dr D Widera
Applications accepted all year round

Funding Type

PhD Type

Adult multipotent stem cells can be easily isolated from a variety of adult human tissues and organs including bone marrow and adipose tissue.
  Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks
  Dr A Antonysunil
Applications accepted all year round

Funding Type

PhD Type

The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children.
  Developing pluripotent stem cell models of inherited retinal diseases
  Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Background. Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide.
  Predicting the development of oral cancer
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Human head and neck cancer is a devastating disease with poor survival rates.
  Determining how immune responses are regulated at mucosal surfaces
  Dr M Travis, Prof D Thornton
Applications accepted all year round

Funding Type

PhD Type

The immune system must be primed to quickly respond to infection, but must also be tightly regulated so it ignores harmless substances and our own tissues.
  Understanding differential responses to retinoid treatments in human health and disease: a precision medicine approach
  Prof R Watson, Dr A Langton
Applications accepted all year round

Funding Type

PhD Type

Retinoids, such as all-trans retinoic acid (t-RA), are endogenous signalling molecules derived from vitamin A that influence a variety of cellular processes through mediation of transcription events in the cell nucleus.
  The functional characterization of the tumour suppressor gene CSMD1 in breast cancer
  Dr S Bell
Applications accepted all year round

Funding Type

PhD Type

CUB and Sushi multiple domains protein 1 (CSMD1) maps to 8p23, a region deleted in many cancers including breast cancer. Our previous work has established that CSMD1 is an independent prognostic marker in ductal breast cancer, with reduced expression associated with high tumour grade and poor survival1.
  Mitochondrial dysfunction in ARDS and therapeutic mechanism of mesenchymal stromal cell derived extracelluar vesicles
  Research Group: Centre for Experimental Medicine
  Dr A Krasnodembskaya, Dr C O'Kane, Prof D McAuley
Application Deadline: 20 January 2020

Funding Type

PhD Type

Acute Respiratory Distress Syndrome (ARDS) is a major cause of acute respiratory failure in critically ill patients requiring mechanical ventilation, with no effective treatment and is associated with high mortality and morbidity.
  Tools for live-cell imaging in the millisecond regime using Electrically Tunable Lenses
  Prof VM Draviam
Application Deadline: 24 January 2020

Funding Type

PhD Type

A fully funded PhD studentship is available for working with cutting-edge technologies in the field of Machine Learning (Computer Vision) and Cell Biology.
  Tools for live-cell imaging in the millisecond regime using Electrically Tunable Lenses
  Prof VM Draviam
Application Deadline: 24 January 2020

Funding Type

PhD Type

A fully funded PhD studentship is available for working with cutting-edge technologies in the field of Machine Learning (Computer Vision) and Cell Biology.
  How does a mammalian cell physically organise the complex processes of gene expression and regulation?
  Research Group: Biomedical Sciences Research Centre
  Dr J Sleeman
Application Deadline: 6 January 2020

Funding Type

PhD Type

Accurate gene expression and regulation in mammalian cells is a hugely complex process, essential for cellular and organismal homeostasis.
  Identification of key determinants affecting the quality of human Cancer specific cytotoxic T cells
  Prof T Dong
Application Deadline: 10 January 2020

Funding Type

PhD Type

The main objective of my group’s research is to focus on the functional aspects of the antigen specific T cells and study the factors affecting Cytotoxic T cells in controlling cancer development.
  Identification of key determinants affecting the quality of human Cancer specific cytotoxic T cells
  Prof T Dong
Application Deadline: 10 January 2020

Funding Type

PhD Type

The main objective of my group’s research is to focus on the functional aspects of the antigen specific T cells and study the factors affecting Cytotoxic T cells in controlling cancer development.
  Development of novel macrophage high-throughput cell-based phenotypic assay for drug screening
  Research Group: Biomedical Research Group
  Dr G Pirianov, Prof S Cellek
Applications accepted all year round

Funding Type

PhD Type

Research Group. Biomedical Research Group. https://www.anglia.ac.uk/science-and-engineering/research/institutes-and-groups/biomedical.
  Elucidation of novel therapy targets for B-cell malignancies
  Dr M Smida
Application Deadline: 20 February 2020

Funding Type

PhD Type

Therapy of B-cell lymphomas and B-cell chronic lymphocytic leukemia is based predominantly on CD20 monoclonal antibodies and/or on three approved targeted drugs.
  Precision Medicine DTP - How do IFITM proteins regulate the Interferon Related DNA-damage Resistance Signature (IRDS) and clinical outcomes in cancers of high unmet clinical need?
  Dr R Sloan, Prof K Ball, Dr S Wilson
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Interferon Induced Transmembrane proteins (IFITMs) are a family of innate immune membrane proteins that can inhibit viral infection at cell entry (e.g.
  Development of ex vivo tissue culture models for developing next-generation biomaterial scaffolds for acellular regenerative medicine.
  Prof I Gibson, Prof N Vargesson
Applications accepted all year round

Funding Type

PhD Type

Bone repair and regeneration can be influenced by various guidance cues, including pharmacological cues, hypoxia environment and chemical cues released from scaffolds [1-3].
  Precision Medicine DTP - An integrated computational-experimental approach to identify and optimise combination drug therapy for non-alcoholic fatty liver disease (NAFLD)
  Research Group: Centre for Inflammation Research
  Prof J Fallowfield, Dr F Menolascina, Prof J Plevris
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease (CLD), affecting 1 in 4 people worldwide.
  Molecular mechanisms regulating the developmental plasticity of pancreatic cancer cells #NDORMS-2020/6
  Dr S Pauklin
Application Deadline: 10 January 2020

Funding Type

PhD Type

Pancreatic cancers are among the most lethal malignancies in human due to highly metastatic characteristics and the poor responsiveness to currently used cancer therapeutics.
  Investigating the requirements of pro-inflammatory signaling in skin and head & neck Squamous Cell Carcinomas
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Squamous cell carcinomas (SCC) are amongst the most common cancer types afflicting man. SCCs most frequently arise from stratified squamous epithelia such as the epidermis or the mucosae of the head and neck.
  Therapeutic opportunities in mutant p53 cancer cells
  Dr P Muller
Application Deadline: 3 January 2020

Funding Type

PhD Type

This 4 year PhD studentship offered in Dr Patricia Muller’s research group is based at the Cancer Research UK Manchester Institute, Alderley Park, Cheshire.
  Clinically relevant mini-organs to identify optimal “chemo”-free treatments for childhood cancer Phase I trials (ref: RDF20/APP/PAL)
  Dr D Pal
Application Deadline: 24 January 2020

Funding Type

PhD Type

Better cancer therapeutics are urgently needed to maximise patient outcome. Cancer drug development is associated with the highest attrition rates thereby underscoring the immediate requirement for improved preclinical models.
  Control of Parathyroid Hormone Secretion
  Dr D Ward, Dr J Bruce
Applications accepted all year round

Funding Type

PhD Type

The regulation of parathyroid hormone (PTH) secretion is of fundamental importance for calcium homeostasis and in mineral conditions affecting bone and the kidneys.
  Megakaryocytes, platelets and Malignant Bone Marrow Fibro
  Dr B Psalia, Prof A Mead
Application Deadline: 10 January 2020

Funding Type

PhD Type

My group focuses on the biology of megakaryocyte cells - large, rare cells found in the bone marrow that release blood platelets into the circulation and also produce many growth factors and other proteins that regulate blood cell development and the bone marrow microenvironment.
  Myocardial biology with a specific focus on the mechanisms underlying cardiac fibrosis and atrial fibrillation
  Dr S Reilly, Prof C Redwood, Assoc Prof M Lei
Application Deadline: 10 January 2020

Funding Type

PhD Type

Cardiac fibrosis is a hallmark histological feature of structural changes in the myocardium associated with virtually all cardiac diseases (e.g., heart failure, hypertension, atrial fibrillation and myocarditis).
  Megakaryocytes, platelets and Malignant Bone Marrow Fibro
  Dr B Psalia, Prof A Mead
Application Deadline: 10 January 2020

Funding Type

PhD Type

My group focuses on the biology of megakaryocyte cells - large, rare cells found in the bone marrow that release blood platelets into the circulation and also produce many growth factors and other proteins that regulate blood cell development and the bone marrow microenvironment.
  Homeostatic mechanisms in human urothelium: balancing of tissue regeneration and differentiation with implications for regenerative medicine and cancer
  Prof J Southgate
Application Deadline: 30 June 2020

Funding Type

PhD Type

The urothelium is the self-regenerating epithelium that lines the bladder, where it is highly specialised to function as a urinary barrier.
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