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Medical / Clinical Science (infection biology) PhD Projects, Programs & Scholarships

We have 58 Medical / Clinical Science (infection biology) PhD Projects, Programs & Scholarships

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  Uncovering new mechanisms of host subversion by the respiratory pathogen Legionella pneumophila
  Research Group: Centre for Experimental Medicine
  Dr G Schroeder, Prof J Bengoechea, Dr B Collins
Application Deadline: 31 March 2020

Funding Type

PhD Type

The Schroeder Team at the Wellcome-Wolfson Institute for Experimental Medicine of Queen’s University Belfast is looking for an enthusiastic new member, motivated to undertake a PhD focussing on host-pathogen interaction and infection biology.
  Understanding mechanisms of lung destruction in patients with non-tuberculous mycobacterial pulmonary infection
  Research Group: Centre for Experimental Medicine
  Prof C O'Kane, Dr G Schroeder
Application Deadline: 31 March 2020

Funding Type

PhD Type

Mycobacterium avium (M avium) is the commonest form of non-tuberculous mycobacterial (NTM) infection, and is prevalence is rising exponentially in the developed world.
  Iron Biology
  Prof H Drakesmith, Dr O Bannard
Application Deadline: 24 July 2020

Funding Type

PhD Type

We study how iron and anaemia influence immunity and infectious diseases. Our research inspires therapies that control iron physiology to improve immunity, combat infections and treat disorders of iron metabolism.
  Iron Biology
  Prof H Drakesmith, Dr O Bannard
Application Deadline: 24 July 2020

Funding Type

PhD Type

We study how iron and anaemia influence immunity and infectious diseases. Our research inspires therapies that control iron physiology to improve immunity, combat infections and treat disorders of iron metabolism.
  Determining how immune responses are regulated at mucosal surfaces
  Prof M Travis, Prof D Thornton
Applications accepted all year round

Funding Type

PhD Type

The immune system must be primed to quickly respond to infection, but must also be tightly regulated so it ignores harmless substances and our own tissues.
  A Role for Proteases in Strepococcus Pneumoniae infection, lung inflammation and injury.
  Research Group: Centre for Experimental Medicine
  Prof C Taggart, Dr S Weldon
Application Deadline: 31 March 2020

Funding Type

PhD Type

Streptococcus pneumoniae (StP) is a microorganism significantly associated with pneumonia. Bacterial pneumonia in humans is often accompanied by a pronounced inflammatory response and the recruitment of large numbers of neutrophils to the lung.
  The respiratory metagenome during exacerbations of asthma
  Prof N Papadopoulos, Prof D Robertson, Dr S Megremis
Applications accepted all year round

Funding Type

PhD Type

Asthma is an international pandemic, with 10% or more of the global population having experience asthma symptoms some time in life.
  Evolutionary insights for engineering improved globin oxygen carriers
  Dr M Berenbrink, Dr J Madine
Applications accepted all year round

Funding Type

PhD Type

Around 2 million red blood cell units at a cost of 120.00 GBP per unit are transfused annually in England alone (http://www.nhsbt.nhs.uk/what-we-do/blood-transfusion/).
  PhD Positions in Cancer Research

Funding Type

PhD Type

Are you looking for excellent research opportunities for your PhD studies at the forefront of cancer research? The German Cancer Research Center (DKFZ)…
  Paediatric airway epithelium in health and disease: cross-talk between paediatric airway epithelium and dendritic cells following respiratory virus infection
  Research Group: Centre for Experimental Medicine
  Prof U Power, Dr D Simpson
Application Deadline: 31 March 2020

Funding Type

PhD Type

This project will be part of a Welcome Trust Strategic award involving 8 major UK universities and Monash University, Australia.
  Adaptation to oxidative stress in hepatitis C virus persistence: the role of IRES-dependent translation.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

Hepatitis C virus (HCV) causes a clinically important disease affecting 3% of the world population (Chan 2014). About 75% of the infection will develop into chronic hepatitis, which can then progress into fibrosis, cirrhosis and hepatocellular carcinoma.
  (WIS) Cross-talk between T cells and intestinal epithelial cells: a new type of immune synapse.
  Prof D Davis, Prof M Travis
Application Deadline: 6 March 2020

Funding Type

PhD Type

Super-resolution and other state-of-the-art microscope techniques allow us to study immune cell activity in unprecedented detail.
  MRC DTP 4 Year PhD Programme: Deciphering the role of oxidative stress in cardiovascular disease using physiological and 3D cell models.
  Dr C Murdoch, Dr C Henderson
Application Deadline: 13 March 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  Elucidating novel disease mechanisms in sepsis
  Research Group: Centre for Experimental Medicine
  Prof T Curtis, Prof J Bengoechea
Application Deadline: 31 March 2020

Funding Type

PhD Type

Sepsis is defined as “life-threatening organ dysfunction due to a dysregulated host response to infection”. It is a major public health problem since it affects millions of people worldwide each year, and it accounts for most deaths in critically ill patients.
  Targeting bacterial protein glycosylation in pathogenic bacteria as a novel anti-virulence strategy
  Research Group: Centre for Experimental Medicine
  Prof M Valvano, Prof G Wagner
Application Deadline: 31 March 2020

Funding Type

PhD Type

Antibiotic resistance is a global health problem of epidemic proportions, especially for infections by Gram-negative bacteria. Identifying novel microbial targets to develop new classes of antimicrobial molecules, which could work alone or in combination with existing antibiotics, is a must.
  Clinical and molecular correlates of response to first line treatment in oral lichen planus
  Dr K Hijazi, Prof J Gibson
Application Deadline: 13 March 2020

Funding Type

PhD Type

Oral lichen planus is a chronic disease of the lining of the mouth that causes pain and increases the risk of oral cancer. The negative impact of oral lichen planus on quality of life has been proven.
  Predicting the development of oral cancer
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Human head and neck cancer is a devastating disease with poor survival rates.
  Development of a three dimensional in vitro model of the human cornea to dissect the inflammatory events associated with sight-threatening ocular pathogens
  Dr C Dobson, Dr C Maldonado-Codina, Prof P Morgan
Applications accepted all year round

Funding Type

PhD Type

The presence of microbes at the corneal surface may trigger low grade discomfort through to acute eye infection and permanent loss of vision.
  MRC DTP 4 Year PhD Programme: Mendelian Randomisation Approaches to defining the Underlying risk factors for the Dementias.
  Dr A Doney, Dr W Meng
Application Deadline: 13 March 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  MRC DTP 4 Year PhD Programme: Proteo-Genomic Analysis for Precision Oncology
  Prof A I Lamond, Prof R Petty
Application Deadline: 13 March 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  Developing new antibody-based therapeutics for neuroblastoma
  Prof A Sala
Applications accepted all year round

Funding Type

PhD Type

Metastatic neuroblastoma is a cancer of the nervous system that kills the majority of the affected children. Although there have been tremendous advances in the understanding of the molecular causes of the disease, patients are still treated with highly toxic mixtures of chemicals and radiation.
  Telomere length elongation following treatment with chemotherapeutic drugs. Aim: To investigate the mechanisms which leads to telomere length elongation after treatment with tricostatin A and azacytidine.
  Dr T Roberts
Applications accepted all year round

Funding Type

PhD Type

Telomeres are specialised structures, which are present at the ends of chromosomes and serve to protect the chromosome from degradation during cell division.
  Investigating the regulation of the RNA modifying enzyme ADAR1 and how it regulates other biological pathways and diseases
  Dr M O'Connell, Dr L Keegan
Application Deadline: 20 February 2020

Funding Type

PhD Type

The ADAR enzymes convert adenosine into inosine in dsRNA. Inosine is one of the most abundant and best studied modifications found in different classes of RNA.
  Development and evaluation of small Inhibitors of HUWE1 for the treatment of Multiple Myeloma
  Research Group: Centre for Cancer Research and Cell Biology
  Dr L Crawford, Dr R Williams
Application Deadline: 24 February 2020

Funding Type

PhD Type

HUWE1 is a large HECT-domain E3 ligase that is involved in the regulation of key proteins such as p53, MYC and MCL-1. We have identified elevated expression of HUWE1 in Multiple Myeloma (MM) and demonstrate that knockdown of this ligase leads to growth arrest of MM cell lines both in vitro and in vivo.
  Identifying novel strategies to block rhinovirus infections through the analysis of virus-host protein-protein interactions in infected cells.
  Research Group: Centre for Experimental Medicine
  Dr A Mousnier, Prof U Power
Application Deadline: 31 March 2020

Funding Type

PhD Type

Rhinovirus infections are the main cause of common colds and a major cause of exacerbation of chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease (COPD), leading to an acute worsening of symptoms.
  Basal stem cells in the lung and their recognition of dying cells
  Prof T Hussell, Dr N Fujino
Applications accepted all year round

Funding Type

PhD Type

Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown.
  Do Altered host-microbial interactions promote oral inflammation during ageing?
  Dr J Konkel, Prof A McBain
Applications accepted all year round

Funding Type

PhD Type

As we age, the systems of our bodies become less able to function; rendering people increasingly infirm. Ageing affects our immune system, impeding our ability to both fight infection and maintain tolerance.
  Virus pathogenesis: interplay between the unfolded protein response and innate immunity.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The unfolded protein response (UPR) is a cellular homeostatic response in restoring endoplasmic reticulum balance upon stress conditions e.g.
  How does cytokine signalling cause kidney hyperplasia?
  Dr M Fragiadaki, Prof J Sayers
Applications accepted all year round

Funding Type

PhD Type

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder, with more than 12 million people are affected worldwide.
  Antimicrobial prescribing in hospice and palliative care
  Dr C Parsons, Dr D Gilpin
Applications accepted all year round

Funding Type

PhD Type

Terminally ill patients are at high risk of infections and antimicrobial exposure near the end of life. However, the evidence-base to guide prescribers in the use of antibiotics for the treatment of infections in patients receiving hospice and palliative care is currently lacking.
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