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Medical / Clinical Science (information studies) PhD Projects, Programs & Scholarships

We have 155 Medical / Clinical Science (information studies) PhD Projects, Programs & Scholarships

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  Development of methods to triangulate multiple sources of evidence
  Prof J Higgins
Application Deadline: 25 November 2019

Funding Type

PhD Type

The University of Bristol is offering a 3.5 year full time PhD in research around Population Health to start in 2019. This studentship is funded through GW4 BioMed MRC Doctoral Training Partnership.
  Assessing the generalisability of trial findings using large orthopaedic population studies #NDORMS-2020/5
  Assoc Prof J Cook, Prof X Griffin, Assoc Prof B Ollivere
Application Deadline: 10 January 2020

Funding Type

PhD Type

Randomised trials (RCTs) are widely accepted as the preferred approach to evaluating health care interventions. However, the clinical relevance and generalisability of the findings are often disputed.
  Genetic approaches to understand the complex links between obesity, socio-cultural factors and mental health. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Dr J Tyrrell
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Jess Tyrrell, College of Medicine and Health, Institute of Biomedical and Clinical Science, University of Exeter.
  GW4 BioMed MRC DTP PhD studentship: Examining the development of sensory-independent plasticity
  Dr K Petrini
Application Deadline: 25 November 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ which is offering up to 18 studentships for entry in September 2020.
  Men with fertility problems are at increased risk of future health problems, this PhD will examine their psychosocial and clinical support needs
  Dr L Ashley, Prof G Jones, Prof B Gough, Prof A Pacey
Application Deadline: 18 November 2019

Funding Type

PhD Type

Men with fertility problems are at increased risk of future health problems including cancer.
  Artificial intelligence and machine learning for clinical prediction: Evaluating design, conduct, reporting and 'spin' #NDORMS-2020/3
  Prof G Collins, Dr M Schlussel, Dr P Dhiman, Dr J de Beyer
Application Deadline: 10 January 2020

Funding Type

PhD Type

1. Professor Gary Collins. 2. Dr Michael Schlussel. 3. Dr Paula Dhiman. 4. Dr Jennifer de Beyer. Artificial intelligence (AI) and machine learning (ML) are increasingly seen as solutions to many healthcare problems (e.g., for risk prediction, imaging), and the pace of development is showing no signs abating.
  Inhibition of PRMT5 as a cancer therapy
  Dr K. Sheppard
Applications accepted all year round

Funding Type

PhD Type

Targeted therapy has had profound impact on outcomes for cancer patients.
  Bioinformatics studies of protein structures, functions and their interactions
  Dr L J McGuffin
Applications accepted all year round

Funding Type

PhD Type

The computational study of protein structures, functions and their interactions is fundamental to our understanding of disease.
  Precision Medicine DTP – Integration of single-cell RNA sequencing data from human and murine kidney disease to identify novel therapeutic targets
  Research Group: Centre for Cardiovascular Science
  Dr BC Conway, Dr T Chandra, Dr D Ferenbach
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease and for end-stage kidney disease (ESRD), at which point patients require dialysis or transplantation.
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  Predicting the development of oral cancer
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Human head and neck cancer is a devastating disease with poor survival rates.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Watching the Hippo pathway in real time in growing organs
  Dr K. Harvey
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  Genetic mechanisms of chronic kidney disease
  Prof M Tomaszewski, Prof A Woolf
Applications accepted all year round

Funding Type

PhD Type

Chronic kidney disease (CKD) is one of the most common complex disorders. The prevalence of CKD is on the rise in all populations around the globe and both the clinical and economic pressures of CKD on the healthcare systems increase exponentially.
  An exploration of the links between mitochondrial function and splicing regulation. PhD in Medical Studies (SWBio DTP)
  Dr L Harries
Application Deadline: 2 December 2019

Funding Type

PhD Type

Lead Supervisor. Professor Lorna Harries, College of Medicine and Health, University of Exeter. Additional Supervisors. - Professor Mark Lindsay, Department of Pharmacy and Pharmacology, University of Bath.
  Normal and Leukaemic Blood Stem/Progenitor Cell Biology
  Prof P Vyas, Prof A Mead
Application Deadline: 10 January 2020

Funding Type

PhD Type

Our laboratory studies the mechanisms regulating normal blood stem and progenitor cell differentiation and how these are perturbed in blood cancers such as Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndromes (MDS).
  Normal and Leukaemic Blood Stem/Progenitor Cell Biology
  Prof P Vyas, Prof A Mead
Application Deadline: 10 January 2020

Funding Type

PhD Type

Our laboratory studies the mechanisms regulating normal blood stem and progenitor cell differentiation and how these are perturbed in blood cancers such as Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndromes (MDS).
  Modelling memristive artificial neurons
  Prof S Saveliev, Dr P Borisov
Applications accepted all year round

Funding Type

PhD Type

Does the brain operate as a computer? In short the answer is no, but why? We use logic when thinking and coming to a decision by linking events in a causal relationship.
  MRC DTP 4 Year PhD Programme: Mendelian Randomisation Approaches to defining the Underlying risk factors for the Dementias.
  Dr A Doney, Dr W Meng
Application Deadline: 11 January 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  Decoding the genetic architecture of inflammatory arthritis at the single-cell level #RACE5
  Dr S Sansom, Prof P Bowness, Dr L Jostins-Dean, Prof K Raza
Application Deadline: 10 January 2020

Funding Type

PhD Type

Supervisors. Dr Stephen Sansom, Professor Paul Bowness, Dr Luke Jostins-Dean and Professor Karim Raza. Genome wide association studies (GWAS) of inflammatory arthritis have now revealed hundreds of genetic variants that are linked to different forms of inflammatory arthritis.
  Can genetics-led immunologic investigation identify novel common regulators shared across immune-mediated inflammatory diseases? #NDORMS-2020/2
  Dr L Chen, Prof P Bowness
Application Deadline: 10 January 2020

Funding Type

PhD Type

Liye Chen. https://www.ndorms.ox.ac.uk/team/liye-chen. Paul Bowness. https://www.ndorms.ox.ac.uk/team/paul-bowness. Immune-mediated inflammatory diseases (IMIDs) are a group of incurable diseases that share inflammatory pathways and cause substantial personal and socioeconomic burdens.
  Use of EUROQOL-5D (EQ-5D) in orthopaedic trauma trials #NDORMS-2020/4
  Assoc Prof J Cook, Prof X Griffin
Application Deadline: 10 January 2020

Funding Type

PhD Type

Health related quality of life is commonly measured in clinical research studies including Randomised Controlled Trials (RCTs). Perhaps the most commonly used to do this is the Euroqol-5 dimensions (EQ-5D) questionnaire (1).
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  Fueling chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Triple-negative breast cancer (TNBC) is a molecularly heterogeneous group of diseases defined by the lack of estrogen receptor (ER), progesterone receptor (PR) and absence of human epidermal growth factor receptor-2 (HER2) amplification.
  Testing the function of immune suppressive cytokines and cells in bone metastasis
  Assoc Prof B Parker
Applications accepted all year round

Funding Type

PhD Type

Bone metastasis is a common occurrence in breast and prostate cancer that leads to patient morbidity and, in many cases, mortality.
  The Hippo pathway and Yap1 in vascular growth control in development and disease
  Prof B Hogan, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Lymphatic vessels play roles in the drainage of tissue fluid, trafficking of immune cells and the metastatic spread of cancer.
  Understanding the mechanisms of neuroendocrine tumour response to radionuclide therapy
  Prof R Hicks, Assoc Prof C Cullinane
Applications accepted all year round

Funding Type

PhD Type

Neuroendocrine tumours (NET) represent a heterogeneous group of tumours that arise in specialized cells found throughout the body.
  Identifying circulating cell-free DNA epigenetic biomarkers for neurodegenerative disorders. PhD in Medical Studies (GW4 Biomed MRC DTP)
  Dr E Dempster
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Emma Dempster, College of Medicine and Health, University of Exeter. Dr Liz Couthard, University of Bristol.
  Investigating the remodelling of inhibitory brain circuits in early Alzheimer’s disease. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Prof A Randall
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Professor Andrew Randall, Medical School, College of Medicine and Health, University of Exeter. Dr Jonathan Witton, College of Medicine and Health, University of Exeter.
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