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Medical / Clinical Science (qub) PhD Projects, Programs & Scholarships

We have 32 Medical / Clinical Science (qub) PhD Projects, Programs & Scholarships

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  Deciphering metabolic pathways in patient-derived retinal pigment epithelium (RPE) as a novel strategy for therapeutic intervention in age-related macular degeneration (AMD)
  Prof A Stitt, Dr A Margariti
Application Deadline: 24 February 2020

Funding Type

PhD Type

AMD is the leading cause of blindness in the Western world. Approximately 90% of AMD patients have the so-called “dry” form (dry-AMD) which manifests as progressive damage to the retinal pigment epithelium (RPE) and accumulation of adjacent extracellular deposits.
  Determining effective radiation / drug combinations for paediatric cancers
  Research Group: Centre for Cancer Research and Cell Biology
  Prof K Mills, Prof K Prise
Application Deadline: 10 March 2020

Funding Type

PhD Type

Current therapeutic options for paediatric cancers have achieved substantial improvements in rates of cure.
  Development and evaluation of small Inhibitors of HUWE1 for the treatment of Multiple Myeloma
  Research Group: Centre for Cancer Research and Cell Biology
  Dr L Crawford, Dr R Williams
Application Deadline: 24 February 2020

Funding Type

PhD Type

HUWE1 is a large HECT-domain E3 ligase that is involved in the regulation of key proteins such as p53, MYC and MCL-1. We have identified elevated expression of HUWE1 in Multiple Myeloma (MM) and demonstrate that knockdown of this ligase leads to growth arrest of MM cell lines both in vitro and in vivo.
  Investigating the costs and benefits of global health partnerships
  Research Group: Centre for Public Health
  Prof D O'Donovan, Prof M Clarke
Application Deadline: 20 February 2020

Funding Type

PhD Type

Globally there is a growing number of health partnerships between institutions in developed countries and institutions in low and middle income countries.
  Mapping Homeless and Inclusion Health services in Northern Ireland
  Research Group: Centre for Public Health
  Prof D O'Donovan, Dr N Hart
Application Deadline: 20 February 2020

Funding Type

PhD Type

Inclusion health services are being developed in Northern Ireland for those experiencing homelessness, vulnerable migrants, sex workers, Gypsies and Travellers, and those in contact with the criminal justice system.
  Role of protein quality control mechanisms in cancer
  Research Group: Centre for Cancer Research and Cell Biology
  Dr C Adrain, Dr E Evergren
Application Deadline: 23 February 2020

Funding Type

PhD Type

The ability to degrade misfolded or unneeded proteins is a fundamental mechanism for cellular homeostasis. This process of ‘protein quality control’ is often rewired during cancer, to allow the growth, spread, or indeed, adaptation of cancer cells to the hostile conditions found within tumours.
  Clinical application of machine learning algorithms to determine appropriate antibiotic use in children with Gram-negative bacteria infections
  Dr Y Hsia, Prof C Hughes
Application Deadline: 29 February 2020

Funding Type

PhD Type

Digital health is a growing and productive field in recent years. The application of machine learning (ML) techniques in electronic healthcare databases has been successfully used for clinical diagnosis, outcome prediction, and disease progression.
  A Role for Proteases in Strepococcus Pneumoniae infection, lung inflammation and injury.
  Research Group: Centre for Experimental Medicine
  Prof C Taggart, Dr S Weldon
Application Deadline: 31 March 2020

Funding Type

PhD Type

Streptococcus pneumoniae (StP) is a microorganism significantly associated with pneumonia. Bacterial pneumonia in humans is often accompanied by a pronounced inflammatory response and the recruitment of large numbers of neutrophils to the lung.
  Elucidating novel disease mechanisms in sepsis
  Research Group: Centre for Experimental Medicine
  Prof T Curtis, Prof J Bengoechea
Application Deadline: 31 March 2020

Funding Type

PhD Type

Sepsis is defined as “life-threatening organ dysfunction due to a dysregulated host response to infection”. It is a major public health problem since it affects millions of people worldwide each year, and it accounts for most deaths in critically ill patients.
  Identifying novel strategies to block rhinovirus infections through the analysis of virus-host protein-protein interactions in infected cells.
  Research Group: Centre for Experimental Medicine
  Dr A Mousnier, Prof U Power
Application Deadline: 31 March 2020

Funding Type

PhD Type

Rhinovirus infections are the main cause of common colds and a major cause of exacerbation of chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease (COPD), leading to an acute worsening of symptoms.
  Klebsiella pneumoniae type VI secretion system: antimicrobial resistance, and virulence genes dissemination.
  Research Group: Centre for Experimental Medicine
  Prof J Bengoechea, Prof M Valvano
Application Deadline: 31 March 2020

Funding Type

PhD Type

Type VI secretion systems (T6SS) kill bacteria and shape microbial populations. Klebsiella pneumoniae is regarded as a global threat to human health due to increasing number of isolates resistant to antibiotics.
  Paediatric airway epithelium in health and disease: cross-talk between paediatric airway epithelium and dendritic cells following respiratory virus infection
  Research Group: Centre for Experimental Medicine
  Prof U Power, Dr D Simpson
Application Deadline: 31 March 2020

Funding Type

PhD Type

This project will be part of a Welcome Trust Strategic award involving 8 major UK universities and Monash University, Australia.
  Targeting bacterial protein glycosylation in pathogenic bacteria as a novel anti-virulence strategy
  Research Group: Centre for Experimental Medicine
  Prof M Valvano, Prof G Wagner
Application Deadline: 31 March 2020

Funding Type

PhD Type

Antibiotic resistance is a global health problem of epidemic proportions, especially for infections by Gram-negative bacteria. Identifying novel microbial targets to develop new classes of antimicrobial molecules, which could work alone or in combination with existing antibiotics, is a must.
  Uncovering new mechanisms of host subversion by the respiratory pathogen Legionella pneumophila
  Research Group: Centre for Experimental Medicine
  Dr G Schroeder, Prof J Bengoechea, Dr B Collins
Application Deadline: 31 March 2020

Funding Type

PhD Type

The Schroeder Team at the Wellcome-Wolfson Institute for Experimental Medicine of Queen’s University Belfast is looking for an enthusiastic new member, motivated to undertake a PhD focussing on host-pathogen interaction and infection biology.
  Understanding mechanisms of lung destruction in patients with non-tuberculous mycobacterial pulmonary infection
  Research Group: Centre for Experimental Medicine
  Prof C O'Kane, Dr G Schroeder
Application Deadline: 31 March 2020

Funding Type

PhD Type

Mycobacterium avium (M avium) is the commonest form of non-tuberculous mycobacterial (NTM) infection, and is prevalence is rising exponentially in the developed world.
  Antimicrobial prescribing in hospice and palliative care
  Dr C Parsons, Dr D Gilpin
Applications accepted all year round

Funding Type

PhD Type

Terminally ill patients are at high risk of infections and antimicrobial exposure near the end of life. However, the evidence-base to guide prescribers in the use of antibiotics for the treatment of infections in patients receiving hospice and palliative care is currently lacking.
  CONTRAsT - Cisplatin analogue gOld Nanoparticles for Tumour RAdiation Therapy
  Dr J Coulter
Application Deadline: 29 February 2020

Funding Type

PhD Type

This three year PhD position is an exciting industrial/academic collaboration which will afford the appointed student the opportunity to work closely with our partners Midatech Pharma.
  Determining the microbiome of the homes of people with chronic respiratory diseases
  Dr D Gilpin, Dr D Downey
Applications accepted all year round

Funding Type

PhD Type

In recent years, our understanding of the microbial world in and around us has radically changed. The idea that we live with a complex and diverse community of microbes, has moved us away from a “hygiene hypothesis”, where having less bacteria was, to put it simply, better.
  Development and testing of deep learning algorithms to predict pulmonary exacerbations and development of antimicrobial resistance in people with chronic respiratory disease
  Dr M Tunney, Prof JS Elborn
Application Deadline: 31 March 2020

Funding Type

PhD Type

In people with Cystic Fibrosis, acute infective exacerbations or ‘flare-ups’ of chronic respiratory infection are the single most important cause of poor outcome and are associated with increased symptoms, reduced lung function and local and systemic inflammation.
  Dissecting novel mechanisms of cysteine protease biology in tumourigenesis
  Dr R Burden, Prof C Scott
Applications accepted all year round

Funding Type

PhD Type

Proteases are known for their role in facilitating tumour development, primarily through processes such as proliferation and invasion.
  Novel drug delivery systems for Schizophrenia treatment
  Dr E Larraneta
Applications accepted all year round

Funding Type

PhD Type

This PhD project aims to develop, characterise and test a new type of implantable device to provide sustained antipsychotic drug delivery for schizophrenia treatment.
  Optimising pharmacological treatment of non-cognitive symptoms in people with dementia
  Dr H Barry, Prof C Hughes
Applications accepted all year round

Funding Type

PhD Type

Non-cognitive symptoms experienced by people with dementia may include agitation, aggression, distress, psychosis, anxiety and depression.
  Peptide hydrogels as a long-acting multipurpose drug delivery platform for combined contraception and HIV prevention
  Dr G Laverty, Prof K Malcolm
Applications accepted all year round

Funding Type

PhD Type

HIV/AIDS is the leading cause of death in women of reproductive age worldwide. HIV and unintended pregnancies are prevalent in developing nations due to the lack of effective female contraceptive choice.
  Peptide hydrogels as novel nanotherapeutic delivery agents enhancing the anti-tumour efficacy of radiotherapy
  Dr J Coulter, Dr G Laverty
Applications accepted all year round

Funding Type

PhD Type

There is a pressing clinical need for effective localised cancer treatments. Addressing this need we will develop a novel drug delivery system comprised of a nanoparticle/drug releasing hydrogel implant.
  Relationship between antibiotic therapy and development of antimicrobial resistance in patients with bronchiectasis
  Dr M Tunney, Prof JS Elborn
Applications accepted all year round

Funding Type

PhD Type

To decrease the risk of acute infective exacerbations or flare-ups of their condition, individuals with bronchiectasis are frequently prescribed long-term oral and inhaled antibiotics.
  Responsive hydrogel platforms towards the prevention of medical device-associated infections
  Dr N Irwin, Dr C McCoy
Applications accepted all year round

Funding Type

PhD Type

Catheter-associated urinary tract infections represent a high priority global healthcare challenge. We have recently identified a suite of non-antibiotic active agents with promising antibacterial and anti-encrustation activities.
  Surface-modified silicone elastomer for medical and drug delivery devices with reduced bacterial adherence and biofilm formation
  Dr L Carson, Prof K Malcolm
Applications accepted all year round

Funding Type

PhD Type

All implanted medical devices, including those fabricated from silicone elastomers, are susceptible colonisation with communities of microorganisms that colonise the surface of the device and rapidly establish biofilm populations.
  To develop an allosteric inhibitor of HDAC6 inhibition in cancer
  Dr F Furlong, Dr I Tikhonova
Applications accepted all year round

Funding Type

PhD Type

The HDAC6 protein is upregulated in cancer and associated with increased proliferation and metastasis. Several HDAC6 inhibitors have been developed and are in clinical trials.
  USP17 as a cancer therapeutic target
  Dr J Burrows
Applications accepted all year round

Funding Type

PhD Type

USP17 is over-expressed in a range of primary tumours including NSCLC, breast, colorectal, cervical, ovarian and osteosarcoma and its depletion has been shown to block the growth of cells from all these cancer types.
  FoodBioSystems DTP - The effect of fruit and vegetable intake on health outcomes: does an apple aday still keep the doctor away?
  Prof J Woodside, Prof J Lovegrove, Dr A Nugent, Dr B Green
Application Deadline: 6 March 2020

Funding Type

PhD Type

Research Group. FOODBIOSYSTEMS BBSRC DTP. Although increased fruit and vegetable intake has been associated with reduced risk of chronic diseases such as cardiovascular disease, this has largely been based on observational evidence, and there are a number of uncertainties regarding these observed links.
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