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University of Leeds, Faculty of Medicine and Health Medical / Clinical Science PhD Projects, Programs & Scholarships

We have 10 University of Leeds, Faculty of Medicine and Health Medical / Clinical Science PhD Projects, Programs & Scholarships

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  Characterisation of a pre-osteoblast subset of human mesenchymal stem cells: implications for novel osteoarthritis and osteoporosis treatment development
  Dr E Jones, Prof D McGonagle
Applications accepted all year round

Funding Type

PhD Type

Osteoarthritis (OA) and osteoporosis (OP) are the most common age-related skeletal diseases. They seriously affect patient’s quality of life and represent a significant healthcare burden to the UK society.
  Developing pluripotent stem cell models of inherited retinal diseases
  Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Background. Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide.
  Enhancing Oncolytic Virus-induced Immunotherapy using Eicosapentaenoic Acid (EPA)
  Dr F Errington-Mais, Dr MA Volpato
Applications accepted all year round

Funding Type

PhD Type

Breast cancer is the most commonly diagnosed cancer in women with triple-negative breast cancer (TNBC) having the worst prognosis, highest death rate and lowest overall survival.
  Gastroesophageal reflux in respiratory disease: pathogenic role and improved management
  Prof L Houghton
Applications accepted all year round

Funding Type

PhD Type

Gastroesophageal reflux (GER) is associated with many lung diseases, including but not limited to idiopathic pulmonary fibrosis (IPF), non-IPF interstitial lung disease (ILD), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), non-CF bronchiectasis, asthma and idiopathic chronic cough.
  Genetic studies of corneal endothelial dystrophies and development of alternative treatment options
  Dr M Ali
Applications accepted all year round

Funding Type

PhD Type

The cornea is the protective front part of the eye that provides most of the eyes focusing power. The endothelium is a single-cell layer on the inside of the cornea that maintains fluid balance and is required for corneal transparency.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  The functional characterization of the tumour suppressor gene CSMD1 in breast cancer
  Dr S Bell
Applications accepted all year round

Funding Type

PhD Type

CUB and Sushi multiple domains protein 1 (CSMD1) maps to 8p23, a region deleted in many cancers including breast cancer. Our previous work has established that CSMD1 is an independent prognostic marker in ductal breast cancer, with reduced expression associated with high tumour grade and poor survival1.
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