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Medical Imaging (structural biology) PhD Projects, Programs & Scholarships

We have 9 Medical Imaging (structural biology) PhD Projects, Programs & Scholarships

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  Harnessing Computational and Structural Biology Platforms for Drug Discovery
  Dr D Cole, Dr N Tatum, Dr E Pohl
Application Deadline: 6 March 2020

Funding Type

PhD Type

The spread of low-cost computing and development of data analysis techniques, such as machine learning, promise to improve our understanding of biological disease mechanisms and the design and prioritisation of new pharmaceutical molecules.
  CRISPR Screen Multiplexing for Uncharacterised Region Function (SMURF)
  Dr L Prendergast, Dr M Martin, Prof S Wedge
Application Deadline: 6 March 2020

Funding Type

PhD Type

CRISPR-Cas9 screening utilising tiling-sgRNA design across genes, permits functional evaluation of protein domains and precise mapping of critical amino acids.
  Harnessing Reactive Phosphorylating Agents for Peptide Bioconjugations
  Dr D Hodgson, Prof I Hickson, Prof M Noble
Application Deadline: 6 March 2020

Funding Type

PhD Type

Protein-protein interactions (PPIs) are central to signalling processes associated with many diseases. Disruption of PPI-mediated pathways offers new therapeutic targets, with great potential for selective, potent inhibition because they can mimic native protein structures.
  Unravelling the mysteries of retinoid signalling
  Dr E Pohl, Prof J Endicott
Application Deadline: 6 March 2020

Funding Type

PhD Type

Retinoids, such as all-trans-retinoic acid (ATRA), are a class of endogenous molecules derived from Vitamin A. These compounds control a wide range of cellular processes in chordates, including differentiation, proliferation and apoptosis, by binding one or more of related transcriptional receptors in the cell nucleus.
  Defining protein degradation machinery in the endoplasmic reticulum underlying resistance mechanisms in cancer
  Assoc Prof J Christianson, Prof Udo Oppermann
Application Deadline: 3 March 2020

Funding Type

PhD Type

Cellular stress is a hallmark of cancers. The restorative homeostatic response mechanisms that often become constitutively engaged, serve to adapt populations to hyperproliferative and metabolically dysregulated states, stabilise malignancy, and elevate resistance to therapeutic agents.
  Cell-permeable cyclic peptide library generation for target-based screening
  Prof A Kawamura, Prof M Waring, Dr SL Cobb
Application Deadline: 6 March 2020

Funding Type

PhD Type

Peptides hold enormous promise as chemical tools for selective intervention in biology. They can target chemical space distinct from that of small molecules and their chemical diversity provides high specificity and affinity or target binding.
  From Fragment-screening to Fragment-growing - new strategies for drug discovery
  Dr E Pohl, Dr C Cano
Application Deadline: 6 March 2020

Funding Type

PhD Type

Type-2 diabetes represents a major health problem in particular in industrialised countries and although many cases may be preventable by lifestyle changes, numbers are steadily rising.
  Molecular Imaging of Collagen in Abdominal Aortic Aneurysms
  Dr A Phinikaridou
Applications accepted all year round

Funding Type

PhD Type

Project Summary. Abdominal aortic aneurysms (AAAs) are permanent dilations of the aorta that exceed 50% of the original size of the vessel or that are greater than 3cm in maximum diameter.
  PhD aiming at building statistical models to identify relationships between rare genomic variations cognition and behavior
  Dr S jacquemont
Applications accepted all year round

Funding Type

PhD Type

Mapping the cognitive genome. Ph.D. in psychiatric genomics. The laboratory of Sébastien Jacquemont is working with several international consortia on projects mapping the relationship between genomic variants, cognition, behavior and brain structure.
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