We have 33 Medical Research Council (Cambridge) PhD Projects, Programmes & Scholarships

Accurate genome duplication is essential for all forms of life. The molecular machinery that orchestrates this process is collectively termed the replisome. Read more

Supervisor: Dr J Yeeles

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Circuit basis of learning and action-selection

Medical Research Council (Cambridge) Laboratory of Molecular Biology

The overall goal of our research is to discover the circuit implementation of learning and action selection. Since these functions likely emerge from… Read more

Supervisor: Dr M Zlatic

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Mechanism of transcription-coupled splicing

Medical Research Council (Cambridge) Laboratory of Molecular Biology

The production of messenger RNA in eukaryotic cells involves precursor mRNA (pre-mRNA) synthesis and processing. During splicing, the spliceosome removes noncoding introns from pre-mRNA in a co-transcriptional manner on the surface of RNA polymerase II (Pol II). Read more

Supervisor: Dr S Zhang

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Cryo-EM structures of GPCRs from pathogenic fungi

Medical Research Council (Cambridge) Laboratory of Molecular Biology

G protein-coupled receptors (GPCRs) are integral membranes that play a key role in fungi through sensing the extracellular environment. Read more

Supervisor: Dr C Tate

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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How to become a germ cell

Medical Research Council (Cambridge) Laboratory of Molecular Biology

Primordial germ cells are the undifferentiated precursors of the gametes and the sole mechanism by which animals transmit genetic information across generations. Read more

Supervisor: Dr M Shahbazi

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Cryo-EM studies of amyloids in neurodegeneration

Medical Research Council (Cambridge) Laboratory of Molecular Biology

Our group develops new algorithms for cryo-EM structure determination and implements these in the popular image processing software RELION. Read more

Supervisor: Dr S Scheres

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Physics of ion interaction with cryoEM specimens

Medical Research Council (Cambridge) Laboratory of Molecular Biology

We wish to study the physical mechanisms of energetic ion interaction with frozen biological specimens at temperatures in the range of 4-100K with the goal of improving specimen preparation for in situ cryoEM. Read more

Supervisor: Dr C Russo

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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LPS ubiquitylation and innate immunity Group Leader Page

Medical Research Council (Cambridge) Laboratory of Molecular Biology

Our ability to fight infections relies on the capacity of our immune system to defend our body and on the skills of individual cells to defend themselves. Read more

Supervisor: Dr F Randow

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Cell biology underlying host-mycobacterium interactions

Medical Research Council (Cambridge) Laboratory of Molecular Biology

TB remains the world’s greatest infectious killer despite a vaccine (BCG) for a century and effective antibiotics for 60 years. TB’s persistence over millennia in the face of major medical advances underscores the ability of Mycobacterium tuberculosis to evade and exploit host defences and antibiotics. Read more

Supervisor: Prof L Ramakrishnan

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Neuroimmune crosstalk in infection and cancer

Medical Research Council (Cambridge) Laboratory of Molecular Biology

Immune reactions against pathogens and tumours require several layers of regulation to ensure the appropriate control of infectious agents and cancerous… Read more

Supervisor: Dr N Rodriguez

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Mechanistic insight into macromolecular machines

Medical Research Council (Cambridge) Laboratory of Molecular Biology

Large multiprotein complexes perform many essential functions in eukaryotic cells. My lab purifies, assays and determines structures of these macromolecular machines to understand their mechanisms. Read more

Supervisor: Dr L Passmore

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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What makes mammalian cells tick?

Medical Research Council (Cambridge) Laboratory of Molecular Biology

Protein homeostasis is essential to the physiological function and viability of eukaryotic cells; particularly neurons, where proteome integrity must be maintained for decades. Read more

Supervisor: Dr J O'Neill

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Visualization of mammalian telomeric complexes

Medical Research Council (Cambridge) Laboratory of Molecular Biology

The ends of linear eukaryotic chromosomes generally consist of tandem G-rich repeats (TTAGGGn in humans), which specifically recruit telomeric protein factors to form large nucleoprotein structures called telomeres. Read more

Supervisor: Dr K Nguyen

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Molecular mechanisms of SMC Complexes

Medical Research Council (Cambridge) Laboratory of Molecular Biology

SMC complexes (cohesin, condensin and others) are essential organisers of genomes in all domains of life. At the centre of their activity is the ability to alter the path of DNA in three dimensions in an energy-dependent fashion. Read more

Supervisor: Dr J Lowe

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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How signals inside the brain make our brains big

Medical Research Council (Cambridge) Laboratory of Molecular Biology

The human brain is unique in many ways, but perhaps the most obvious difference compared with other primates is its size. How the human brain gets to be so large during development specifically in humans is a question that has long intrigued neuroscientists but until recently was difficult to study. Read more

Supervisor: Dr M Lancaster

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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We have 33 Medical Research Council (Cambridge) PhD Projects, Programmes & Scholarships

Medical Research Council (Cambridge) PhD Projects, Programmes & Scholarships

We have 33 Medical Research Council (Cambridge) PhD Projects, Programmes & Scholarships

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