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University of Oxford Medicine PhD Projects, Programmes & Scholarships

We have 51 University of Oxford Medicine PhD Projects, Programmes & Scholarships

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Medicine

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University of Oxford

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We have 51 University of Oxford Medicine PhD Projects, Programmes & Scholarships

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Understanding the effects of immunomodulatory therapies on radiation response

Dying cancer cells are thought to be a rich source of tumour antigens and danger signals into the tumour microenvironment. Work from the Olcina lab has found that targeting complement can increase tumour cell death following radiotherapy which may in turn modulate anti-tumour immune responses. Read more

Nucleases and helicases as potential cancer targets

It is clear that the acquired genetic changes (vulnerabilities) in tumours can be exploited to treat cancer, increasingly in a manner tailored to individual patients. Read more

Investigating the role of E3 ubiquitin ligases in cancer pathogenesis

The Ubiquitin Proteasome System (UPS) is a crucial regulator of cell survival in normal conditions and after DNA damage. The function of UPS is dysregulated in cancer, thus providing a large repertoire of targets to exploit for better cancer treatment. Read more

Parallels between the biological response to viral infection and hypoxia

Regions of low oxygen or hypoxia occur in most solid tumours and predict for a poor patient outcome. Cancer cells adapt to hypoxic conditions and become resistant to therapy, therefore finding new strategies to target tumour hypoxia is essential to improve patient care. Read more

Characterisation of DNA-protein crosslink proteolysis repair in response to chemotherapy

DNA-protein crosslinks (DPCs) are under-investigated DNA lesions caused by the covalent attachment of proteins to DNA. DPCs are induced by endogenous aldehydes, chemotherapeutic drugs (such as PARP1 or Topoisomerase inhibitors) and ionising radiation. Read more

Personalised Radionuclide Theranostics for Cancer

The adoption of highly effective anticancer radiopharmaceuticals such as 223Ra, 177Lu[Lu]-PSMA and 177Lu[Lu]-DOTATAE and, in some cases, their companion imaging tracers, into oncologic practise over the last few years has invigorated the field of radiopharmaceutical therapeutics. Read more

Non-invasive phenotyping of muscle function using multi-nuclear MR

Commercial partner. RAPID Biomedical GmbH. , Rimpar, Germany. Breathlessness, fatigue on exertion and exercise intolerance are common features of obesity, type II diabetes and heart failure. Read more

Assessing the prospective utility of AlzoSure® Predict in a UK clinical research cohorts to assess risk of Alzheimer’s Disease

Commercial partner: . Diadem Research Ltd. , London. The proposed project is in the field of neurodegeneration and fits within the MRC strategic theme of prevention and early detection, facilitating earlier diagnosis and improved clinical management. Read more

Development of a digital behavioural intervention to reduce dementia risk in ageing adults

Commercial partner: . Five Lives SAS. , London. This programme offers an exciting opportunity for multi-disciplinary research, working with a dedicated team of scientists, clinicians, and informaticians, to address the UK’s #1 public health problem, dementia. Read more

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