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We have 26 Microbiology (cell culture) PhD Projects, Programmes & Scholarships

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Microbiology (cell culture) PhD Projects, Programmes & Scholarships

We have 26 Microbiology (cell culture) PhD Projects, Programmes & Scholarships

Diagnostics for FMF patients and carrier survival in pandemics

Background. Familial Mediterranean Fever (FMF) is a rare inherited genetic disease where patients acquire a mutation on the pyrin gene leading to excessive inflammasome activation and excessive inflammation. Read more
Last chance to apply

Investigating the role of thymosin beta 10 in feline chronic kidney disease

Chronic kidney disease is an extremely common but heterogeneous condition in cats that adversely affects their health and welfare and is the most frequent cause of death in cats over five years of age. Read more

Exploring Myxobacteria as live antibiotics against pathogenic bacteria

Multi-drug resistant (MDR) bacteria have been identified as a global threat to humanity, limiting therapeutic options. The search for new antibiotics lags far behind the occurrence of MDR bacteria with no new antibiotics brought to the clinic for over 15 years. Read more

The impact of nutritional scavenging on host-pathogen interactions, antifungal efficacy and emergence of antifungal resistance

Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more

Control and inhibition of virus replication

The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more

Dysfunctional antifungal potency of the respiratory mucosa in COPD

Inhalation of Aspergillus fumigatus spores cause >3,000,000 chronic and >200,000 invasive diseases annually worldwide. Invasive aspergillosis carries a 50% mortality rate overall, but mortality rate approaches 100% if diagnosis is delayed or missed and it is >75% in certain cohorts of patients, such as COPD sufferers. Read more

Chaperones and the response to protein misfolding stress

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Fully funded PhD student position in structural biology of viruses

PhD position in the structural biology of viruses. The Department of Chemistry is opening a PhD position in Chemistry with a specialization in structural biology. Read more

Developing 3D models to understand how interactions between bacterial biofilm and the host environment impact antimicrobial efficacy in a chronic infected wound

2.8 million people in the UK have a chronic wound which persist for months or years, causing pain, isolation, odour, and decreased mobility; patients with chronic wounds regularly report a deterioration in quality of life. Polymicrobial biofilms are present in greater than 70% of chronic wounds, making effective treatment incredibly challenging. Read more

Unravelling the role of genotoxic E. coli in colorectal cancer (SCHULLERS_U24BIGC)

Primary supervisor - Dr Stephanie Schüller. Secondary supervisor - Prof Nathalie Juge. Colorectal cancer (CRC) is the third most common and second most fatal cancer globally. Read more

Immune regulation of lung repair, and long-term consequences of infection

This project is one of 14 four year PhD Studentships funded by Medical Research Scotland (MRS) (https://www.medicalresearchscotland.org.uk) to be delivered jointly by the named University and External Partner Organisation (EPO). Read more

Understanding the transcriptional regulation of BK polyomavirus

As obligate intracellular pathogens, viruses rely on host-cell machinery to facilitate their lifecycle. Nuclear-replicating DNA viruses are exposed to factors that can dictate the transcriptional output of the invading viral genome and ultimately influence infection outcome. Read more

Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

  Research Group: Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more

Developing the next generation of broad-spectrum antiviral polymers

Applications are invited for a funded PhD position in the School of Chemistry at the University of Birmingham. The School of Chemistry is keen to achieve a gender and diversity balance across the School and welcomes applicants from all backgrounds. Read more

Virus antigenic evolution under immune pressure

About the Project. The persistent evasion of COVID-19 from vaccines and monoclonal antibody therapeutics underscores the critical need to comprehend how endemic and zoonotic viruses evolve to counter antibody-mediated immune responses. Read more
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