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Microbiology (sexual) PhD Projects, Programs & Scholarships

We have 21 Microbiology (sexual) PhD Projects, Programs & Scholarships

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  Biology and genetics of reproduction in filamentous fungi
  Prof P S Dyer
Applications accepted all year round

Funding Type

PhD Type

Filamentous fungi are of importance in the food, industrial and medical sectors and have important roles in the ecology of natural ecosystems.
  (WIS) How food-borne Listeria monocytogenes overcomes the host defence mechanisms at the single cell level?
  Prof I Roberts, Dr P Paszek
Application Deadline: 6 March 2020

Funding Type

PhD Type

Pathogens have developed intricate ways to overcome the host’s immune system. In this proposal we will study the direct interaction of macrophages with the important food-borne bacterial pathogen Listeria monocytogenes that causes significant human morbidity and mortality.
  Adaptation to oxidative stress in hepatitis C virus persistence: the role of IRES-dependent translation.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

Hepatitis C virus (HCV) causes a clinically important disease affecting 3% of the world population (Chan 2014). About 75% of the infection will develop into chronic hepatitis, which can then progress into fibrosis, cirrhosis and hepatocellular carcinoma.
  Deciphering Aspergillus fumigatus - Pseudomonas aeruginosa synergistic interactions in coinfection
  Dr J Amich, Prof E Bignell, Dr S Fowler
Applications accepted all year round

Funding Type

PhD Type

Pathogen-pathogen interactions in polymicrobial infections are known to directly impact, often to worsen, disease outcomes. Aspergillus fumigatus is the most common fungal pathogen and Pseudomonas aeruginosa one of the most prevalent bacterial pathogens of the human lung.
  Development of a three dimensional in vitro model of the human cornea to dissect the inflammatory events associated with sight-threatening ocular pathogens
  Dr C Dobson, Dr C Maldonado-Codina, Prof P Morgan
Applications accepted all year round

Funding Type

PhD Type

The presence of microbes at the corneal surface may trigger low grade discomfort through to acute eye infection and permanent loss of vision.
  Development of an in vitro model to dissect the mechanism of fungal persistence in the cystic fibrosis lung
  Prof P Bowyer, Dr M Bromley, Dr S Gago
Application Deadline: 28 February 2020

Funding Type

PhD Type

Cystic fibrosis (CF) is the most common fatal genetically inherited disease in Caucasian populations. This disease is caused by mutations in the cystic fibrosis transmembrane regulator gene (CFTR) which produces defective ion fluxes and calcium homeostasis in the epithelia.
  Exploring molecular mechanisms of drug resistance and pathogenicity in the filamentous fungus Aspergillus fumigatus
  Dr M Bromley, Prof P Bowyer
Applications accepted all year round

Funding Type

PhD Type

A. fumigatus is the primary etiological agent of invasive aspergillosis, a disease that primarily affects individuals who are immunocompromised, and causes 200k life threatening infections annually.
  Exploring the Skin Microbiome’s response to UV light and investigating whether this response alters in the presence of UV filters
  Prof C A O'Neill, Prof A McBain
Application Deadline: 28 February 2020

Funding Type

PhD Type

UV light has a substantial effect on our skin which has been characterised well and documented throughout literature. Most of the available data in this area focusses on the damaging effects of UV light on the epidermis and dermis of the skin.
  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
  Investigating the role of bioactive lipids in skin health
  Prof A Nicolaou, Prof C A O'Neill
Applications accepted all year round

Funding Type

PhD Type

Human skin depends on systemic provision of fatty acids that are important to maintain the integrity of the epidermal barrier as well as to support the associated immune and inflammatory reactions.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
  Probing the organization and function of bacterial toxin-antitoxin complexes
  Dr F Hayes, Prof J P Derrick
Applications accepted all year round

Funding Type

PhD Type

Bacterial toxin-antitoxin (TA) modules typically consist of a pair of genes that encode for a stable toxin protein and an unstable cognate antitoxin molecule.
  Protease-resistant antimicrobial peptides to target bacterial and fungal pathogens
  Dr J Bella, Dr L Tabernero
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance is quickly becoming a serious global health problem. The emergence of multidrug-resistant microbial strains combined with the drying up of the antibiotic pipeline in the pharmaceutical industry has significantly worsened the situation in recent years.
  Regulation of intestinal immune responses to commensal bacteria by innate lymphoid cells
  Dr M Hepworth, Prof K Else
Applications accepted all year round

Funding Type

PhD Type

Commensal bacteria present in the gastrointestinal tract provide beneficial roles for the host, such as supporting nutrient metabolism.
  Tackling antibiotic resistance: developing a vaccine against gonorrhoea
  Prof J P Derrick, Dr F Hayes
Applications accepted all year round

Funding Type

PhD Type

Gonorrhoea is caused by the Gram-negative bacterium Neisseria gonorrhoeae and is a serious public health problem in developing and developed countries.
  The contribution of human mast cells to innate functional memory in anti-bacterial responses
  Prof S Bulfone-Paus, Dr J Cavet
Applications accepted all year round

Funding Type

PhD Type

In the recent years, it has become evident that after infection or vaccination innate immune cells have the capacity to adapt and modify the nature of their activities following a single immunostimulatory challenge and display a long-term functional memory.
  The respiratory metagenome during exacerbations of asthma
  Prof N Papadopoulos, Prof D Robertson, Dr S Megremis
Applications accepted all year round

Funding Type

PhD Type

Asthma is an international pandemic, with 10% or more of the global population having experience asthma symptoms some time in life.
  The role mRNA-specific translation during chronological aging
  Prof C M Grant, Prof M Ashe, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Biological ageing can be thought of as a progressive decline in the ability of an organism to survive stress and disease. It is a complex process which is influenced by both genetic and environmental factors.
  Ultrastructural analysis of the mouse whipworm as a model for human trichuriasis
  Prof R K Grencis, Dr T Starborg
Applications accepted all year round

Funding Type

PhD Type

Gastrointestinal dwelling nematode parasites are extremely successful parasites of both man and animals infecting over a billion people worldwide and are responsible for considerable morbidity and ill health worldwide.
  Using synthetic biology to understand the evolution of antibiotic resistance
  Dr M Lagator, Dr C Knight
Applications accepted all year round

Funding Type

PhD Type

Imagine an architect, tasked with converting an old stadium into a building with a different function, without demolishing it.
  Virus pathogenesis: interplay between the unfolded protein response and innate immunity.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The unfolded protein response (UPR) is a cellular homeostatic response in restoring endoplasmic reticulum balance upon stress conditions e.g.
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