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The University of Manchester, Faculty of Biology, Medicine and Health Microbiology PhD Projects, Programs & Scholarships

We have 33 The University of Manchester, Faculty of Biology, Medicine and Health Microbiology PhD Projects, Programs & Scholarships

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Showing 1 to 10 of 33
  (A*STAR) RNA-based sensors of host-imposed stress in the major fungal pathogen of human lungs: Potential as drug targets
  Prof E Bignell, Prof J Micklefield
Application Deadline: 31 January 2020

Funding Type

PhD Type

The often-fatal fungal lung disease invasive aspergillosis (IA) has claimed more than 8 million human lives since its. emergence ~ 40 years ago.
  (A*STAR) Unravelling the metabolic basis of Aspergillus fumigatus adaptation to combinatorial stress conditions
  Dr J Amich, Prof E Bignell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Aspergillus fumigatus is an environmental saprophytic fungus that lives ubiquitously in the soil. This fungus can also infect the lungs of individuals with any kind of immune imbalance, causing a broad range of diseases collectively termed aspergillosis.
  (BBSRC DTP) Exploring the developing microbiome in new-born babies
  Dr S Cruickshank, Prof A McBain, Dr C Knight
Application Deadline: 31 January 2020

Funding Type

PhD Type

The gut microbiome contains a large diverse community of microorganisms with our bacteria being best understood. These bacteria play crucial roles for our health such as aiding in the digestion of food, production of key vitamins and metabolites and programming out immune system.
  (BBSRC DTP) Exploring the host-microbiome interactions to promote healthy skin function
  Prof A Nicolaou, Prof A McBain, Prof C A O'Neill, Dr A Kendall
Application Deadline: 31 January 2020

Funding Type

PhD Type

The surface of our skin is an intriguing landscape covered by a diverse population of microorganisms that are collectively known as the cutaneous ‘microbiome’.
  (BBSRC DTP) From mucin biochemistry to pulmonary immunity: How do mucins promote antimicrobial lung defences?
  Prof E Bignell, Prof D Thornton, Dr A Horsley
Application Deadline: 31 January 2020

Funding Type

PhD Type

Respiratory mucus plays multiple essential roles in mammalian lung function, from hydrating the epithelium and supporting gaseous exchange, to expelling inhaled particles and microbes and providing a conduit for innate and adaptive immune signaling.
  (BBSRC DTP) Mechanism of early steps in protein synthesis by cryoEM imaging of supramolecular complexes
  Dr A Roseman, Prof G D Pavitt, Prof C Baldock
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of this project is to understand the mechanism and control of protein synthesis in eukaryotic cells at the molecular level, particularly focused around the role of the eukaryotic translation initiation factors eIF2, eIF5 and eIF2B.
  (BBSRC DTP) Metals and bacterial virulence: overcoming metal intoxication during infection
  Dr J Cavet, Dr D Linton, Prof J Lloyd
Application Deadline: 31 January 2020

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen, being the leading bacterial cause of human acute gastroenteritis and responsible for an estimated 0.5 billion cases each year.
  (BBSRC DTP) Optimisation of heteromeric protein complex formation via co-ordinated mRNA localisation
  Prof M Ashe, Dr M Pool, Prof C M Grant
Application Deadline: 31 January 2020

Funding Type

PhD Type

RNA granules play key roles in cells controlling many aspects of mRNA fate. For instance, in response to stress the relocalisation of mRNAs to mRNA processing bodies (P-bodies) and stress granules facilitates the degradation or storage of unwanted or valuable mRNAs, respectively.
  (BBSRC DTP) Plant-based production of a vaccine against gonorrhoea
  Prof J P Derrick, Dr A Day
Application Deadline: 31 January 2020

Funding Type

PhD Type

The sexually transmitted disease gonorrhoea is caused by the Gram-negative bacterium Neisseria gonorrhoeae. N. gonorrhoeae is a close relative of Neisseria meningitidis, which causes meningococcal meningitis.
  (BBSRC DTP) Tackling the genomic dark matter through system engineering of ncRNAs in yeast
  Prof D Delneri, Prof P Cai
Application Deadline: 31 January 2020

Funding Type

PhD Type

Non-coding RNAs (ncRNAs) are thought as of genomic "dark matter" for which the biological significance has been largely underestimated.
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