The University of Manchester Microbiology PhD Projects, Programmes & Scholarships

We have 20 The University of Manchester Microbiology PhD Projects, Programmes & Scholarships

(MRC DTP CASE) Determination of the role of viruses in the microbiome of biofilms formed in the ear of patients with otitis media

The University of Manchester Faculty of Biology, Medicine and Health

Otitis media (OM) is a very common infection of the middle ear characterised by redness, swelling and build-up of fluid behind the eardrum. Read more

Supervisors: Prof P Vallely, Prof P Klapper, Prof S Lovell, Mrs JN Nichani

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) The emerging fungal order Mucorales: species-specific pathogenic strategies and new diagnostics

The University of Manchester Faculty of Biology, Medicine and Health

Mucormycoses are emerging lethal fungal infections, with striking mortality rates of 50-90% depending on the clinical presentation, infection site and underlying host immune status. Read more

Supervisors: Dr M Bertuzzi, Dr N.V.R Van Rhijn

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning

The University of Manchester Faculty of Biology, Medicine and Health

The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more

Supervisors: Dr M Lagator, Prof M Rattray

Year round applications PhD Research Project Self-Funded PhD Students Only

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Eco-evolutionary optimization of synthetic phage therapy

The University of Manchester Faculty of Biology, Medicine and Health

Background. Bacteriophages are viruses that infect bacterial cells, use their cellular machinery to assemble new phage virions, and then kill the cell via lysis to release the virions. Read more

Supervisors: Prof M Brockhurst, Prof P Cai, Dr CI Igler

15 June 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Eco-evolutionary dynamics of environmental microbiomes

The University of Manchester Faculty of Biology, Medicine and Health

Include details on the project, outlining the objectives, methods and potential outcomes. Include details of training/techniques to be provided. Read more

Supervisors: Prof M Brockhurst, Dr S Nixon, Dr K Coyte

15 June 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Diagnostics for FMF patients and carrier survival in pandemics

The University of Manchester Faculty of Biology, Medicine and Health

Background. Familial Mediterranean Fever (FMF) is a rare inherited genetic disease where patients acquire a mutation on the pyrin gene leading to excessive inflammasome activation and excessive inflammation. Read more

Supervisors: Dr P Arkwright, Dr G Lopez-Castejon, Dr J Cavet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the mechanistic basis of Aspergillus fumigatus and Non-tuberculous mycobacteria coinfection

The University of Manchester Faculty of Biology, Medicine and Health

Respiratory infections caused by bacteria, fungi and viruses are a global cause of death according to the WHO. Respiratory coinfections are on the rise and in general linked with poor patient outcomes. Read more

Supervisors: Dr S Gago, Dr CK Kosmidis, Prof L Tabernero

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of Human cytomegalovirus glycoprotein polymorphisms in disease pathogenesis

The University of Manchester Faculty of Biology, Medicine and Health

Human cytomegalovirus (HCMV) produces asymptomatic infection in most immunocompetent individuals but thereafter establishes life-long infection with periodic reactivation and asymptomatic shedding. Read more

Supervisors: Prof P Vallely, Prof P Klapper

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the protective effects of a commensal bacterial strain in skin barrier function and protection from disease

The University of Manchester Faculty of Biology, Medicine and Health

Maintaining a healthy skin barrier is vital for our health. In response to skin wounding, we have a well-orchestrated immune response that heals the breach. Read more

Supervisors: Prof S Cruickshank, Prof A McBain, Dr R Unwin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genotypic and phenotypic markers of resistance in Aspergillus fumigatus and their impact on outcomes in chronic pulmonary aspergillosis

The University of Manchester Faculty of Biology, Medicine and Health

Chronic pulmonary aspergillosis (CPA) is a progressive infection affecting patients with chronic lung disease. It significantly affects quality of life and mortality. Read more

Supervisors: Dr CK Kosmidis, Dr M Bromley, Dr R Richardson, Dr M Bottery, Prof T Hussell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Drug repurposing for the treatment of aspergillosis

The University of Manchester Faculty of Biology, Medicine and Health

The mould Aspergillus fumigatus was classified by the WHO as a critical priority pathogen in 2022. It causes a spectrum of invasive, allergic and chronic disease. Read more

Supervisors: Dr CK Kosmidis, Prof D Ashcroft, Dr M Bottery, Dr M Bromley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Dysfunctional antifungal potency of the respiratory mucosa in COPD

The University of Manchester Faculty of Biology, Medicine and Health

Inhalation of Aspergillus fumigatus spores cause >3,000,000 chronic and >200,000 invasive diseases annually worldwide. Invasive aspergillosis carries a 50% mortality rate overall, but mortality rate approaches 100% if diagnosis is delayed or missed and it is >75% in certain cohorts of patients, such as COPD sufferers. Read more

Supervisors: Dr M Bertuzzi, Dr J.H Herbert, Dr S Gago

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of regulatory evolution in phage ecology

The University of Manchester Faculty of Biology, Medicine and Health

The regulation of genes crucially determines the fitness and function of all organisms. This is particularly relevant for bacteriophages, the viruses that infect bacteria, as they rely on a tightly scheduled program for a successful infection. Read more

Supervisors: Dr M Lagator, Dr CI Igler

Year round applications PhD Research Project Self-Funded PhD Students Only

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Optimizing phage-antibiotic-synergies to kill bacterial pathogens

The University of Manchester Faculty of Biology, Medicine and Health

Phage therapy, the use of viruses that only infect bacterial cells and kill them, is a promising potential solution to the antimicrobial resistance crisis that is threatening modern medicine1. Read more

Supervisors: Prof M Brockhurst, Dr CI Igler

Year round applications PhD Research Project Self-Funded PhD Students Only

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The impact of nutritional scavenging on host-pathogen interactions, antifungal efficacy and emergence of antifungal resistance

The University of Manchester Faculty of Biology, Medicine and Health

Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more

Supervisors: Dr N.V.R Van Rhijn, Dr M Bromley

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 20 The University of Manchester Microbiology PhD Projects, Programmes & Scholarships

The University of Manchester Microbiology PhD Projects, Programmes & Scholarships

We have 20 The University of Manchester Microbiology PhD Projects, Programmes & Scholarships

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