Medical Research Council (Cambridge), Mitochondrial Biology Unit PhD Projects, Programmes & Scholarships

We have 6 Medical Research Council (Cambridge), Mitochondrial Biology Unit PhD Projects, Programmes & Scholarships

The role of mitochondrial membrane remodelling in controlling mtDNA levels and heteroplasmy

Medical Research Council (Cambridge) Mitochondrial Biology Unit

Mitochondria are dynamic organelles generating a specific network by membrane remodeling events according to cellular needs1. Mitochondria contain multiple copies of their own genome, mtDNA, a circular molecule that encodes for 13 proteins involved in energy production through oxidative phosphorylation. Read more

Supervisors: Dr Julien Prudent, Dr M Minczuk

4 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Genetic approaches for rational development of animal models of complex I-linked mitochondrial disease

Medical Research Council (Cambridge) Mitochondrial Biology Unit

Mutations in mitochondrial complex I genes are common causes of primary mitochondrial neuromuscular diseases such as Leigh syndrome. Read more

Supervisors: Prof Judy Hirst, Dr A J Whitworth

4 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Genetic engineering of the human mitochondrial genome

Medical Research Council (Cambridge) Mitochondrial Biology Unit

Mammalian mitochondria contain several copies of their own genome (mtDNA) which encodes 13 essential subunits of the oxidative phosphorylation (OXPHOS) system. Read more

Supervisor: Dr M Minczuk

4 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Structure and mechanism of the human mitochondrial ADP/ATP carrier

Medical Research Council (Cambridge) Mitochondrial Biology Unit

The mitochondrial ADP/ATP carrier, also called the adenine nucleotide translocase, imports ADP into the mitochondrial matrix and exports ATP, which are key steps in oxidative phosphorylation. Read more

Supervisor: Prof E Kunji

4 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Analysing the role of mitochondrial calcium in neurodegeneration

Medical Research Council (Cambridge) Mitochondrial Biology Unit

Mitochondrial calcium plays a key role in a wide array of cellular homeostatic processes and has been linked to causing neurodegeneration. Read more

Supervisor: Dr A J Whitworth

4 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Combining cryoEM and mutagenesis to determine how respiratory complex I works

Medical Research Council (Cambridge) Mitochondrial Biology Unit

Complex I (NADH:ubiquinone oxidoreductase) is an intricate ~1 MDa multimeric membrane-bound complex that is essential for mitochondrial metabolism. Read more

Supervisor: Prof Judy Hirst

4 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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We have 6 Medical Research Council (Cambridge), Mitochondrial Biology Unit PhD Projects, Programmes & Scholarships

Medical Research Council (Cambridge), Mitochondrial Biology Unit PhD Projects, Programmes & Scholarships

We have 6 Medical Research Council (Cambridge), Mitochondrial Biology Unit PhD Projects, Programmes & Scholarships

The role of mitochondrial membrane remodelling in controlling mtDNA levels and heteroplasmy

Genetic approaches for rational development of animal models of complex I-linked mitochondrial disease

Genetic engineering of the human mitochondrial genome

Structure and mechanism of the human mitochondrial ADP/ATP carrier

Analysing the role of mitochondrial calcium in neurodegeneration

Combining cryoEM and mutagenesis to determine how respiratory complex I works

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