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University of Leicester, Molecular and Cell Biology PhD Projects, Programs & Scholarships

We have 11 University of Leicester, Molecular and Cell Biology PhD Projects, Programs & Scholarships

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Molecular and Cell Biology  University of Leicester

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We have 11 University of Leicester, Molecular and Cell Biology PhD Projects, Programs & Scholarships

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Understanding cellular receptors mediating signalling and viral infection - molecular mechanisms and development of new therapeutics

Cellular receptors initiate signalling pathways that regulate all aspects of cell behaviour and these receptors are key therapeutic targets for a wide range of diseases including cardiovascular disease and cancer. Read more

Understanding gene regulation by HDAC1 complexes in development and cancer

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

Determining the roles that GRK and arrestin proteins play in the development of hypertension and vascular disease

G protein-coupled receptors (GPCRs) constitute a very large family of heptahelical, integral membrane proteins that mediate a wide variety of physiological processes ranging from the transmission of light and odorant signals to the mediation of neurotransmission and hormonal actions. Read more

Cancer biology: identification of new treatment options for EML4-ALK driven lung cancer through understanding mechanisms of cell division and migration.

Lung cancer is the largest cause of cancer-related deaths in the UK and worldwide. While little progress has been made in long-term survival rates, we now have a good understanding of the genetic drivers raising the prospect of earlier diagnosis and more effective treatments. Read more

How do RNA-binding proteins control splice site selection? A multi-disciplinary approach.

Almost every protein-coding gene in vertebrates can and does express multiple proteins. This is achieved primarily by RNA splicing, which is an essential step in gene expression in mammals and generates incredible diversity. Read more

3D genome folding and its role in DNA-based processes

The organization of genomic DNA into chromatin fibres and nucleosomes and their regulation by histone modifications is well understood, as is the relevance of these mechanisms for gene regulation. Read more

Revealing epigenetic signaling mechanisms in genome regulation and cancer.

We are looking for highly motivated PhD students to join our efforts to reveal epigenetic mechanisms that regulate the function of eukaryotic genomes in health and disease. Read more

Molecular Modelling of P2X receptor function

P2X receptors (P2XR) are a family of ligand-gated ion channels. P2XRs are activated upon binding of extracellular ATP and allow the influx of small cations after channel opening. Read more

Obtaining an integrated understanding of oncogenic RAS signalling

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more
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