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We have 21 Molecular Biology (BBSRC) PhD Projects, Programmes & Scholarships

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Molecular Biology (BBSRC) PhD Projects, Programmes & Scholarships

We have 21 Molecular Biology (BBSRC) PhD Projects, Programmes & Scholarships

Enzyme Cascades controlled in the Electrochemical Leaf for Discovery in Antimicrobial Strategy

Antibiotic discovery is usually aimed at single entities, for example a bacterial enzyme or efflux protein. This also means that antimicrobial resistance (AMR) mechanisms are considered in terms of the individual response, for example, mutations in a single target enzyme, affording resistance to the drug. Read more

Revealing Reactivity in Cancer-Associated Heme Proteins: Novel Time-Resolved Structural Approaches

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme involved in the degradation of tryptophan to kynurenine. Cancer cells upregulate IDO1 to escape normal immune responses and, in many cases, a high expression of IDO1 is connected to poor prognosis. Read more

Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more

Natural products in bacterial physiology and chemical interaction

Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more

Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more

Nuclear and transcriptional dysregulations during cellular senescence

Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more

Molecular level understanding of Mycobacterium tuberculosis

Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more

Self-funded PhD- Understanding the molecular mechanism of a bacterial genome defence system and its synergy with CRISPR-Cas

Prokaryotes have evolved over billions of years alongside their viruses, the bacteriophages, or “phages”. To prevent viral infection, prokaryotes have evolved rudimentary immune mechanisms, the most widespread and well-studied of which are the Restriction-Modification and the CRISPR-Cas enzymes. Read more

Novel glycoprotease discovery and characterisation for enhanced detergent performance

In this exciting joint academia-industry project the student will exploit metagenomes and the huge untapped capacity of the human gut microbiota to breakdown glycoconjugates to discover novel protease enzymes that can potentially increase the performance and environmental sustainability of leading P&G automatic dishwashing brands. Read more

Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more

Development of LA1011 for high affinity binding to Hsp90 for use towards healthy ageing in patients showing Alzheimer’s symptoms

  Research Group: Biochemistry
With 50 million global cases of Alzheimer’s disease (AD) and care costs of 1 trillion UK pounds (expected to triple by 2050), there is a pressing need to slow disease progression, sustain productive lives and reduce costs. Read more

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