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We have 167 Molecular Biology (english language) PhD Projects, Programmes & Scholarships

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Molecular Biology (english language) PhD Projects, Programmes & Scholarships

We have 167 Molecular Biology (english language) PhD Projects, Programmes & Scholarships

Experimental and computational Cancer PhD: Overcoming osteosarcoma chemoresistance by characterizing and targeting cellular quiescence

Cancer is the leading cause of death in children and the second in young adults in England and Wales. Sarcomas, tumours that originate from connective tissues (bone, muscle, fat), account for around 15% of childhood cancers. Read more

Investigating mechanisms of extra-cellular matrix remodelling and fibrosis in the gastrointestinal tract

Inflammatory bowel diseases, such as Crohn's disease, are increasing in prevalence globally. These are caused by chronic inflammation in the gut, there is no cure and medications are not effective for all. Read more

Molecular characterisation of post-tuberculous bronchiectasis

Tuberculosis is a major health problem is Iraq and globally. While treatment of TB, including MDR TB has greatly improved resulting in high rates of clinical cure, many patients with TB are left with persisting lung disease including airflow obstruction and bronchiectasis. Read more

Targeting the extracellular matrix remodelling for the treatment of obesity-associated cardio-renal dysfunction

Obesity is a risk factor for many chronic metabolic diseases including heart failure and chronic kidney disease. Our lab demonstrated a tight association between increased deposition of extracellular matrix components (e.g. Read more

Mitigating the impact of environmental stress on the quality and sustainability of malting barley

Climate change is challenging our ability to reliably grow crops. This PhD will be focused on the impact this is having on our capacity to produce a sustainable supply of malted barley for use within the brewing and distilling industries. Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Developing novel targeted therapeutic approaches through induced-proximity of proteins

Protein post-translational code is at the heart of protein function and signal transduction in cells. Enzymes catalyse the addition or removal of post-translational modifications (PTM), such as phosphorylation, methylation, acetylation, and ubiquitylation, on proteins. Read more

Unravelling the biophysical mechanisms that regulate liver fibrosis

Applications are invited for a Postgraduate studentship, supported by the Engineering and Physical Sciences Research Council Doctoral Training Programme, to be undertaken within the College of Health and Life Sciences at Aston University. Read more

How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

This is an interdisciplinary project. It will provide a unique opportunity to obtain training in a wide range of interdisciplinary skills, including protein engineering techniques, protein purification, atomic force microscopy, neutron reflection and scattering as well as molecular dynamics simulations. Read more

Control and inhibition of virus replication

The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more

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