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Molecular Biology (genes) PhD Projects, Programs & Scholarships

We have 122 Molecular Biology (genes) PhD Projects, Programs & Scholarships

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  Genomics, gene regulation and disease: how mammalian genes are regulated and how their deregulation is linked with human disease
  Assoc Prof J Hughes, Prof T Milne
Application Deadline: 26 July 2019

Funding Type

PhD Type

The Hughes group is interested in how mammalian genes are regulated and how their deregulation is linked with human disease. The ~22 thousand genes in the mammalian genome are present in the DNA of every cell but are used in complex patterns in different cell types and organs.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Investigation of the role of myopia susceptibility genes in early eye development.
  Prof L Erskine, Prof N Vargesson, Prof M Collinson
Application Deadline: 28 June 2019

Funding Type

PhD Type

The aim of this project is to determine the role of inherited refractive error risk factors in the pre-birth development of the eye.
  Engineering tRNA neochromosomes in yeast
  Prof P Cai, Prof D Delneri
Applications accepted all year round

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  Using canine models of obesity to discover the mechanisms by which genes influence obesity.
  Dr E Raffan, Dr D Sargan
Applications accepted all year round

Funding Type

PhD Type

We are interested in discovering the mechanisms by which genes influence obesity. The dog is an excellent model organism for human comparative analyses.
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Social networking: Understanding promiscuity in the transfer of bacterial virulence genes
  Research Group: Institute of Infection, Immunity & Inflammation
  Prof JR Penades
Application Deadline: 1 September 2019

Funding Type

PhD Type

The development of novel multiresistant hypervirulent strains from formerly avirulent or only weakly virulent strains is dramatically fuelled by the acquisition of mobile genetic elements carrying virulence factors.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  Understanding the role of HoxA9 in chemotherapy resistance of Acute Myeloid Leukaemia (AML)
  Dr M Esposito
Applications accepted all year round

Funding Type

PhD Type

Acute Myeloid Leukaemia (AML) is a rare but yet deadly form of blood cancer. Genome-wide expression arrays and RNA sequencing have contributed to unravelling the leukaemia signature genes.
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