University of Leeds Featured PhD Programmes
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Molecular Biology (investigation) PhD Projects, Programs & Scholarships

We have 30 Molecular Biology (investigation) PhD Projects, Programs & Scholarships

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  EMBLA Project - Using single molecule microscopy to investigation the regulation of phase transition by alternative splicing
  Dr R Weatheritt
Applications accepted all year round

Funding Type

PhD Type

More than 90% of human genes undergo alternative splicing, the process by which multiple, distinct transcript and protein variants are expressed from a single gene.
  Investigation of a probiotic strain of Lactobacillus plantarum 2025 and the development of novel antibacterials
  Prof A Karlyshev
Applications accepted all year round

Funding Type

PhD Type

Background. The rise of multidrug resistant forms of microbial pathogens imposes a serious problem to public health worldwide. The rapid spread of antimicrobial resistance is associated with misuse of conventional antibiotics.
  Investigation of a Novel Regulator of Plant Yield and Fitness in Plants
  Dr P Gallois, Dr G Johnson
Applications accepted all year round

Funding Type

PhD Type

Autophagy is an incredibly important and highly conserved process across eukaryotes and involves the regulated destruction of unnecessary or damaged components within the cell.
  Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
  Dr A Kitmitto, Dr E Cartwright
Applications accepted all year round

Funding Type

PhD Type

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease.
  MSc Project: Chronic lung infection – Investigation of the mechanisms of adaptation during chronic colonisation.
  Dr S McClean
Application Deadline: 3 April 2020

Funding Type

PhD Type

Chronic lung infections are associated with poor quality of life and mortality for people with underlying respiratory conditions such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD).
  Investigation of host-microbial derived biomarkers for the early detection of age-related cognitive decline and dementia (VauzourMEDOct2020)
  Dr D Vauzour, Prof M Muller
Application Deadline: 17 April 2020

Funding Type

PhD Type

Applications are invited for a PhD studentship funded by the Faculty of Medicine and Health working under the supervision of Dr David Vauzour and Pr Michael Müller.
  Investigation of mechanisms of neuroprotective oxidative stress response induction by mesenchymal stem cell extracellular vesicles using human pluripotent stem cell resources
  Research Group: Centre for Clinical Brain Sciences
  Dr P De Sousa, Dr T Wishart
Application Deadline: 3 April 2020

Funding Type

PhD Type

Adult-tissue derived mesenchymal stem cells (MSC) and derivative extracellular vesicles (EV) attenuate neuroinflammation, and elicit neuroprotective oxidative stress response in animal and cell models of neurodegenerative diseases and injury.
  Investigation of the role of post-translational modifications in hypoxia signalling
  Dr V See, Prof C E Eyers
Applications accepted all year round

Funding Type

PhD Type

The hypoxia signalling pathway is required for the adaptation of cells to a low oxygen environment, which cells can experience in various physiological and pathological circumstances related to high altitude, development, wound healing and cancer.
  Dietary bioactives modulate vascular function: a mechanistic investigation.
  Dr G Corona
Applications accepted all year round

Funding Type

PhD Type

In the UK, over three million people currently suffer from cardiovascular diseases and healthy foods rich in protective dietary factors are known to help slow vascular ageing and improve the quality of life.
  EPSRC Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine (LifETIME)

Funding Type

PhD Type

The CDT will train the next generation of leaders in developing in vitro tissues, sensing and diagnostics to develop humanised in vitro systems to drive better drug screening.
  Characterisation of the role of Panx1/Panx2 in primary endothelial cells
  Dr M Boumechache
Applications accepted all year round

Funding Type

PhD Type

Pannexins are a family of proteins that are evolutionary related to the gap-junction forming proteins, innexins (1). Three members have been identified, Panx1, Panx2 and Panx3, and they show distinct tissue distribution.
  Sex differences of ultra-endurance running: Profiling of female ultra-runners
  Dr H Moir
Applications accepted all year round

Funding Type

PhD Type

Ultra-endurance running has become increasingly popular, both in amateur and recreational athletes, with an exponential increase in the number of ultra-marathon finishers between 1998 and 2011 (Cejka et al., 2013; Hoffman & Krishnan 2013;).
  EPSRC Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine (LifETIME)

Funding Type

PhD Type

The CDT will train the next generation of leaders in developing in vitro tissues, sensing and diagnostics to develop humanised in vitro systems to drive better drug screening.
  Characterising human metalloproteome to disrupt metal toxicity induced neurodegeneration (Ref: SF20/APP/SOUNDARARAJAN)
  Dr M Soundararajan
Applications accepted all year round

Funding Type

PhD Type

Metal accumulation and biometal dyshomeostasis in the nervous system leads to loss of neuronal function.
  Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism in liver cancer
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

The Hippo/Yap pathway is an evolutionarily conserved cascade that plays a fundamental role in governing organ size control, stem cell homeostasis and cancer.
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