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Molecular Biology (screening) PhD Projects, Programs & Scholarships

We have 68 Molecular Biology (screening) PhD Projects, Programs & Scholarships

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  Precision Medicine DTP – Development of clinically relevant models of undifferentiated pleomorphic sarcoma using a genetic screening approach
  Research Group: Edinburgh Cancer Research Centre
  Prof V Brunton, Dr L Boulter, Dr M Taylor, Prof D M Salter
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Sarcomas are relatively uncommon cancers thought to arise from pluripotent mesenchymal stem cells. Undifferentiated pleomorphic soft tissue sarcoma (UPS), though one of the commonest sarcoma subtypes encountered, exemplify the limitations of historical progress in sarcoma therapy.
  MRC DiMeN Doctoral Training Partnership: Software, Synthesis and Screening: cheminformatic led invention, design and synthesis of novel compounds for the treatment of septic shock
  Prof JPA Harrity, Dr G Richards, Dr A Hogben, Dr A Pannifer
Application Deadline: 6 January 2020

Funding Type

PhD Type

Industrial and academic medicinal chemists take advantage of modern cheminformatic and biology technologies to inform and guide their science.
  High-throughput discovery of combination therapies and engineering of CRISPR/therapeutic proteins
  Dr A Wong
Applications accepted all year round

Funding Type

PhD Type

Our lab is interested in developing and applying state-of-the-art combinatorial genetics technologies to decipher the mechanisms behind complex diseases, including cancers and neurodegenerative disorders, and discover novel combination therapies.
  Evaluation of ex vivo screening methodology
  Dr S Danson, Prof T Helleday
Applications accepted all year round

Funding Type

PhD Type

Cancer affects over 14M individuals worldwide each year and in the UK only 50% of patients have a 10 year survival following cancer diagnosis.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  Modelling Neurocristopathies in Xenopus, mechanisms and drug screening (WHEELERGU19MCETN1)
  Dr G N Wheeler
Application Deadline: 16 December 2019

Funding Type

PhD Type

NEUcrest is an Innovative Training Network (ITN) project, funded by the European Union Horizon 2020 Programme.
  (BBSRC DTP CASE) Intelligent Engineering of Bacterial Genomes
  Prof R Breitling, Prof E Takano
Application Deadline: 31 January 2020

Funding Type

PhD Type

The goal of this project is to establish methodology for the intelligent engineering of biological hosts for the production of high-value drugs and chemicals.
  Cloning and expression of topoisomerase genes from Trypanosoma brucei (SteverdingD-2U19SF)
  Dr D Steverding
Application Deadline: 31 May 2020

Funding Type

PhD Type

Topoisomerases (TOPs) are essential enzymes that catalysis topological changes in DNA. TOPs are pivotal to cell survival and therefore inhibitors have been developed to target these enzymes both for antimicrobial and anti-cancer chemotherapy.
  EASTBIO A synthetic biology approach to design ‘intelligent’ organoids for the study of host-microbe interactions
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr E Cachat, Dr L Boulter
Application Deadline: 5 January 2020

Funding Type

PhD Type

Organoids are self-organised, 3D structures generated in vitro from adult or pluripotent stem cells, that exhibit similar functionality as their tissue of origin.
  High-throughput discovery of novel antibiotics using synthetic microbiology
  Dr R Draheim
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is a frequent problem in the treatment of disease caused by several clinical bacterial pathogens. In the European Union, antibiotic-resistant infections kill nearly 25,000 patients and represent a total expenditure of £1.5 billion per year.
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