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Molecular Biology (selection) PhD Projects, Programs & Scholarships

We have 28 Molecular Biology (selection) PhD Projects, Programs & Scholarships

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  Multilevel selection on transposition rates in cancer
  Dr L J Johnson
Applications accepted all year round

Funding Type

PhD Type

Cancer is an evolutionary process. Cells in a tumour vary due to mutation, and so over many generations they adapt in response to both intrinsic selective pressures (such as anoxia) and extrinsic selective pressures (such as chemotherapy).
  High-throughput discovery of combination therapies and engineering of CRISPR/therapeutic proteins
  Dr A Wong
Applications accepted all year round

Funding Type

PhD Type

Our lab is interested in developing and applying state-of-the-art combinatorial genetics technologies to decipher the mechanisms behind complex diseases, including cancers and neurodegenerative disorders, and discover novel combination therapies.
  De Novo Mutations and Human Disease
  Prof A Goriely, Prof A Wilkie
Application Deadline: 24 July 2020

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
  De Novo Mutations and Human Disease
  Prof A Goriely, Prof A Wilkie
Application Deadline: 24 July 2020

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
  Development and Maturation of B cell Mediated Immune Responses
  Dr O Bannard
Application Deadline: 24 July 2020

Funding Type

PhD Type

We study the cellular interactions and molecular events that lead to the development of high affinity and protective antibodies during humoral immune responses.
  Immunogenetic Status of Salmonid Populations in Scotland
  Prof S Piertney, Dr M Wenzel, Dr D Morris, Dr J Gilbey
Application Deadline: 1 May 2020

Funding Type

PhD Type

The genetic integrity of wild salmon in Scotland is being challenged by interaction with escaped farmed fish.
  Construction of QSAR models for searching multi-target drug hits beyond similarity-based applicability domains
  Dr X Liu, Dr J Meng, Prof F Falciani
Applications accepted all year round

Funding Type

PhD Type

Drugs designed to act against individual molecular targets cannot usually combat multigenic diseases such as cancers in which alternative or compensatory pathways are often activated.
  Investigate a novel, unexplored link between WNT signalling and regulators of cell migration in cancer progression using CRISPR-Cas9 and advanced live cell imaging.
  Dr M Krause
Applications accepted all year round

Funding Type

PhD Type

Cancer is a devastating disease. more than one in three people in the UK will develop cancer in their lifetime. WNT signalling is a key pathway controlling morphogenesis in embryos and it has been shown that perturbations of this pathway promote cancer progression.
  Four Year PhDs in Cancer, Immunology and Biomedicine

Funding Type

PhD Type

The Faculty of Medicine at the University of Southampton has a strong reputation in research, enterprise and education, with an emphasis on translating new discoveries from basic science into clinical innovation.
  Bacteriophage role in the establishment of preterm infants’ gut microbiota (Ref: SF20/APP/SMITH3)
  Dr D Smith
Applications accepted all year round

Funding Type

PhD Type

Survival of very preterm infants has increased over the last 20 years, but late onset sepsis (LOS) and necrotising enterocolitis (NEC) remain a major cause of death and ongoing developmental problems in this population.
  Temperate bacteriophages and Antimicrobial Resistance (AMR) (Ref: SF20/APP/SMITH2)
  Dr D Smith
Applications accepted all year round

Funding Type

PhD Type

Bacterial genomes are studded with prophage regions, some that can be stimulated to produce active phages that horizontally transfer their genomes between related bacterial species.
  The role of bacteriophages in Pseudomonas aeruginosa infection in Chronic Respiratory disease. (Ref: SF20/APP/SMITH1)
  Dr D Smith
Applications accepted all year round

Funding Type

PhD Type

Pseudomonas aeruginosa is a key opportunistic respiratory pathogen in patients with cystic fibrosis and non-cystic fibrosis bronchiectasis.
  Epigenetic mechanisms of phenotypic plasticity and the evolution of adaptive responses
  Dr R Hager, Prof J McInerney
Applications accepted all year round

Funding Type

PhD Type

We now live in a world of rapidly changing environmental conditions where species will need to adapt or perish. While populations may evolve in response to environmental change, more rapid responses may happen through processes like phenotypic plasticity.
  MSc Project: Chronic lung infection – Investigation of the mechanisms of adaptation during chronic colonisation.
  Dr S McClean
Application Deadline: 3 April 2020

Funding Type

PhD Type

Chronic lung infections are associated with poor quality of life and mortality for people with underlying respiratory conditions such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD).
  Effect of nanoparticles on cellular conditions in lymphocytes and germ cells in vitro
  Research Group: Chemistry and Biosciences
  Prof D Anderson, Dr M Najafzadeh
Applications accepted all year round

Funding Type

PhD Type

The use of metals such as silver (Ag), gold (Au) and copper (Cu) as nanoparticles (NPs) and other chemicals such as Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (Najafzadeh et al., 2016) in medical and lifestyle applications has exponentially increased in recent years, yet little is still known about their impact on DNA and RNA in somatic as well as in germ cells (Habas et al 2018).
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