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Molecular Biology (signal) PhD Projects, Programs & Scholarships

We have 34 Molecular Biology (signal) PhD Projects, Programs & Scholarships

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  Unraveling the signal regulation network of cell adhesion, migration, and invasion in podosomes and invadopodia
  Dr C Yu
Applications accepted all year round

Funding Type

PhD Type

Integrin-mediated adhesions, such as podosomes and invadopodia, are the biophysical anchor to sense and to translate mechanobiological signals into various cellular events.
  Structural mechanism of signal-dependent gene transcription
  Prof D Panne, Dr A Revyakin
Application Deadline: 7 June 2020

Funding Type

PhD Type

PhD Start date. September 2020. The control of gene transcription is the main regulatory step for cellular gene regulation.
  Cardiotoxicity of cancer drugs targeting the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
  Prof A Clerk
Applications accepted all year round

Funding Type

PhD Type

"Heart failure is a leading cause of morbidity and mortality worldwide. The contractile cells of the heart, cardiomyocytes, possess many protective mechanisms, allowing them to withstand pathophysiological stresses.
  Characterisation of cell death pathways upon activation of the endoplasmic reticulum stress sensor IRE1alpha
  Dr M Schroeder
Applications accepted all year round

Funding Type

PhD Type

A self-funded PhD project to investigate cell death pathways activated by endoplasmic reticulum (ER) stress is available in the group of Dr.
  TRPM2 channel mechanism of neuroinflammation and neurodegeneration in Alzheimer’s disease
  Research Group: School of Biomedical Sciences
  Dr L H Jiang, Dr I Wood
Applications accepted all year round

Funding Type

PhD Type

Alzheimer’s disease (AD) is the most common cause of dementia and also a major cause of morbidity and mortality. Currently, there is no effective therapeutics to treat or slow the disease progress.
  Environmental maternal effects and intergenerational inheritance
  Research Group: CENTA - Central England NERC Training Alliance
  Dr A Pires da Silva, Prof G Bending
Application Deadline: 29 May 2020

Funding Type

PhD Type

Project Highlights. Mechanisms by which organisms rapidly respond to sudden environmental changes. Mother senses environmental stress signals to produce stress-resistant progeny.
  Investigating the impact of hypoxia on T lymphocytes
  Dr S Ross
Application Deadline: 28 May 2020

Funding Type

PhD Type

PhD Studentship Opportunity – October 2020. The Babraham Institute is a world-leader in fundamental biological research investigating the systems that underpin development and healthy ageing.
  FGFR signalling in breast cancer
  Dr A Chioni
Applications accepted all year round

Funding Type

PhD Type

Growth factors are used during development to convey messages that tell cells to divide, survive, migrate and adopt a particular fate.
  A multiple modality approach for targeting treatment-resistant ovarian cancer
  Dr E. Sanij, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer (HGSOC) accounts for 70% of ovarian cancer (OvCa) deaths and its five-year survival rate is 43%.
  mRNA translation reprogramming and metabolic re-wiring in response to ribosome-targeted therapies
  Prof R. Pearson, Dr J Kang
Applications accepted all year round

Funding Type

PhD Type

Increased synthesis and activity of ribosomes are associated with oncogenesis downstream of the major oncogenes including MYC, RAS and PI3K.
  Modelling of Oral Neutrophil Epithelial interactions
  Dr E Hagi-Pavli
Applications accepted all year round

Funding Type

PhD Type

Background and Clinical Significance. Neutrophils are an important and vital cellular component of the innate immune system providing rapid protection against microbial invasion.
  A functional proteomic approach to reveal how receptor tyrosine kinases trafficking specifies cancer cell responses
  Dr C Francavilla, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Background and goals. Cells respond appropriately to their surroundings by activating plasma membrane spanning receptors like Receptor Tyrosine Kinases (RTKs) and thereby adapting long-term outputs (e.g.
  Proteomic analyses of adhesion signalling in cancer
  Prof M J Humphries
Applications accepted all year round

Funding Type

PhD Type

Why adhesion? Cell surface adhesion receptors play key roles in the control of cell movement, survival, division and differentiation.
  The functions of the Class II Pi3-kinase signals in vivo
  Dr L MacDougall, Dr M Baron
Applications accepted all year round

Funding Type

PhD Type

Phosphoinositide lipids (PIPs) play critical roles in development and the homeostasis of adult tissues and their dysfunction has been linked to major human diseases such as cancer, diabetes, myopathies and neuropathies.
  Understanding mechanisms of Notch regulation and misregulation in endocytic pathway
  Dr M Baron, Dr R Clarke
Applications accepted all year round

Funding Type

PhD Type

Notch is a developmental signalling receptor with widespread and important roles in metazoan development and also in adult stem cell regulation.
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