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Molecular Biology (structural) PhD Projects, Programs & Scholarships

We have 44 Molecular Biology (structural) PhD Projects, Programs & Scholarships

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We have 44 Molecular Biology (structural) PhD Projects, Programs & Scholarships

Structural biology of the Ccr4-Not nuclease complex using electron paramagnetic resonance (EPR) spectroscopy and integrative modelling

The ultimate goal in molecular biology is to understand normal physiology and disease processes at atomic resolution. Methods such as x-ray crystallography and NMR spectroscopy have been phenomenally successful in the past decades and continue to be the workhorses of structural biology. Read more

Structural and functional analysis of DNA double strand break repair.

Eukaryotic cells have evolved complex molecular systems in order to detect and repair double-strand breaks (DSBs) of the DNA helix, which can arise from exposure to genotoxic agents or during normal nucleic acid metabolism. Read more

Structural analysis of the inter-membrane bacterial secretosome

Protein secretion is essential for life. Bacteria secrete proteins for a wide range of membrane and extracellular activities, including envelope biogenesis, pathogenicity and degradation of antibiotics. Read more

Neuroinflammation in Alzheimer’s disease: what is the role of amyloid-beta fibril structure?

This project will explore the role of amyloid-beta fibril structure in triggering neuroinflammation in Alzheimer’s disease. Alzheimer’s disease is the most common form of dementia and affects millions worldwide. Read more

Unravelling the structure and conformational dynamics of membrane proteins using H/D-exchange mass spectrometry and cryo-EM

A dynamic studentship which includes experience working in both academic and pharmaceutical industry environments. the project is performed in partnership between laboratories at both King’s College London and UCB Pharma (Slough, 20 miles West of Central London). Read more

Myocardial biology with a specific focus on the mechanisms underlying cardiac fibrosis and atrial fibrillation

Cardiac fibrosis is a hallmark histological feature of structural changes in the myocardium associated with virtually all cardiac diseases (e.g., heart failure, hypertension, atrial fibrillation and myocarditis). Read more

The mechanism of regulation of protein synthesis via eIF2 molecular complexes

Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2]. Read more

Protein engineering enzymes for Industry

 . We are interested in key features of the protein sequence - structure - function relationship, and how this information can be translated to health. Read more

Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

  Research Group: School of Molecular and Cellular Biology
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Simulation-led investigation and engineering of enzymes involved in abyssomicin antibiotic biosynthesis

Enzymes are remarkable biocatalysts that allow rapid, selective and efficient catalysis under mild conditions. Biotechnology exploits the outstanding rate-enhancing properties of these natural biocatalysts to manufacture high added-value products. Read more

EPSRC Centre for Doctoral Training in Molecular Sciences for Medicine - 4 year PhD Studentships

The CDT in Molecular Sciences for Medicine (MoSMed) is a joint venture between Newcastle and Durham Universities. It will train the next generation of researchers at the interface of molecular and medical sciences, business skills, innovation and entrepreneurship. Read more

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