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Molecular Biology (transgenic) PhD Projects, Programs & Scholarships

We have 21 Molecular Biology (transgenic) PhD Projects, Programs & Scholarships

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  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round

Funding Type

PhD Type

Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  LaNts in wound repair, stem cell activation and squamous cell carcinoma
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The Laminin N terminus proteins (LaNts) are a relatively unstudied protein family that are related to netrins and laminins. To date there are only two publications and one preprint about the LaNt proteins in the literature which means there is a massive potential to do novel, ground breaking research in this area.
  (MRC DTP) Investigating the role of neuroinflammation and cholesterol metabolism in the progression of brain injury following intracerebral haemorrhage
  Dr P Kasher, Dr D Brough, Prof S Allan, Dr A Parry-Jones
Application Deadline: 15 November 2019

Funding Type

PhD Type

Intracerebral haemorrhage (ICH) is a type of stroke caused by spontaneous bleeding within the brain.
  Can improved genetic understanding of grain weight help feed the world? (UAUYJ20DTP)
  Dr C Uauy
Application Deadline: 25 November 2019

Funding Type

PhD Type

Wheat provides 20% of the calories and protein consumed by humans. The world population will reach 9 billion by 2050, which requires food production to more than double.
  How does epithelial tissue organization modulate pluripotent stem cell identity and fate?
  Dr M Shahbazi
Application Deadline: 3 December 2019

Funding Type

PhD Type

During embryogenesis pluripotent stem cells give rise to all the cell types present in the organism. How pluripotent cells decide their fate is a fundamental question in development and regeneration.
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round

Funding Type

PhD Type

The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Early detection of colorectal cancer
  Dr V Li
Application Deadline: 12 November 2019

Funding Type

PhD Type

This 4-year PhD studentship is offered in Dr Vivian Li’s Group based at the Francis Crick Institute (the Crick).
  Generation of transplant tissue following correction of patient stem cells by genomic engineering
  Dr F Manson, Dr RL Taylor, Dr A Adamson
Applications accepted all year round

Funding Type

PhD Type

A number of retinal degenerations result from mutations in genes expressed in the retinal pigment epithelium (RPE) which lies under the photoreceptors.
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round

Funding Type

PhD Type

Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
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