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Molecular Biology (processing) PhD Projects, Programs & Scholarships

We have 78 Molecular Biology (processing) PhD Projects, Programs & Scholarships

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  EASTBIO: Recurrent evolution of a eukaryotic molecular trait: acquisition of polycistronic RNA processing.
  Dr J Pettitt, Dr B Mueller, Dr M Wenzel, Prof I Stansfield
Application Deadline: 5 January 2020

Funding Type

PhD Type

Supervisors. Dr Jonathan Pettitt (University of Aberdeen). https://www.aberdeenwormlab.org/. Dr Berndt Mueller (University of Aberdeen).
  Convergent molecular mechanisms of autism resulting from mis-processing of RNA-binding proteins
  Dr C Sibley, Dr J Mason, Dr A Cardona-Alberich
Application Deadline: 12 January 2020

Funding Type

PhD Type

Project Code. 2020-SIDB-07. Autism has a wide variety of potential genetic causes. However, afflicted individuals share common gene expression signatures to suggest converging mechanisms and disease drivers are involved.
  Understanding the role that the RNA helicase UPF1 plays in sorting ribonucleoprotein (RNP) complexes and the mechanism by which this role of UPF1 might reduce cellular stress and cell degeneration.
  Research Group: BBSRC MIBTP
  Dr S Brogna
Application Deadline: 7 January 2020

Funding Type

PhD Type

This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  Mechanistic, structural, and functional studies of a human carbohydrate processing enzyme
  Research Group: Biomedical Sciences Research Centre
  Dr T Gloster
Application Deadline: 6 January 2020

Funding Type

PhD Type

Carbohydrates, or sugars, are ubiquitous throughout nature and perform a number of important functions in our cells.
  Discovery and modelling of common molecular mechanisms disrupting hearing in genetic mutations associated with hearing loss
  Prof I D Forsythe, Dr A Lecchini-Visintini
Application Deadline: 12 January 2020

Funding Type

PhD Type

Objectives. Determine the cellular and molecular changes in the auditory brainstem of mice carrying genetic mutations associated with hearing loss and language development and use modelling to evaluate common mechanisms.
  RNA metabolism in response to cellular stress
  Dr P Grzechnik, Dr S Brogna
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of the project is to understand roles for mRNA processing during the stress response in eukaryotic cells. Exposure to acute stress reduces cell viability or fitness and therefore immediate adaption is crucial for cell survival.
  Chemo-enzymatic Synthesis and Potential Applications of Novel Heterocyclic Alkaloids
  Dr H Deng, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  In Silico design and chemoenzymatic synthesis of bioactive cyclic and stapled peptides
  Dr W Houssen, Dr S Dall'Angelo, Dr G S Bewick
Application Deadline: 24 January 2020

Funding Type

PhD Type

Cyclic and modified cyclic peptides are very appealing scaffolds especially as therapeutics with several examples reach the clinic e.g.
  Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression
  Dr D Blažek, Assoc Prof Z Zdráhal, Dr P Alexiou
Application Deadline: 18 December 2019

Funding Type

PhD Type

CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development.
  Regulation of mitochondrial gene expression (On the University’s application portal, please select "PhD in Medical Science at the MRC Mitochondrial Biology Unit").
  Dr M Minczuk
Application Deadline: 30 June 2020

Funding Type

PhD Type

MRC Mitochondrial Biology Unit. The key objective of this PhD project is to study nuclear-encoded proteins involved in mitochondrial (mt-) RNA metabolism, in order to understand how their dysfunction is linked to human mitochondrial pathologies.
  (BBSRC DTP) Optimisation of heteromeric protein complex formation via co-ordinated mRNA localisation
  Prof M Ashe, Dr M Pool, Prof C M Grant
Application Deadline: 31 January 2020

Funding Type

PhD Type

RNA granules play key roles in cells controlling many aspects of mRNA fate. For instance, in response to stress the relocalisation of mRNAs to mRNA processing bodies (P-bodies) and stress granules facilitates the degradation or storage of unwanted or valuable mRNAs, respectively.
  Phenotyping placental disease in women with diabetes and chronic hypertension using transcriptomic analysis
  Dr J Myers, Dr E Johnstone
Applications accepted all year round

Funding Type

PhD Type

Placental disease triggers medically-indicated preterm birth in 1 in 6 pregnancies complicated by chronic hypertension and/or diabetes (cardiometabolic disease).
  BBSRC MIBTP: Transcriptional regulators of gene expression in human cells
  Dr P Grzechnik, Dr S Brogna
Application Deadline: 12 January 2020

Funding Type

PhD Type

Position for a PhD student is available in the group of Dr Pawel Grzechnik at the University of Birmingham. The aim of the project is to uncover novel roles for transcriptional factors and to investigate how mRNA processing alters gene expression in human cells.
  MRC DTP 4 Year PhD Programme: Investigating mRNA cap regulation in pluripotency and differentiation
  Prof V Cowling, Prof T A Owen-hughes
Application Deadline: 11 January 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  EASTBIO - An integrative approach to understanding the mechanobiology of liver regeneration
  Dr M Bernabeu, Prof N Henderson
Application Deadline: 5 January 2020

Funding Type

PhD Type

The liver has a unique ability to regenerate [1], however in many cases of chronic liver disease this regenerative capacity is overwhelmed.
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