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We have 540 Molecular Biology PhD Projects, Programmes & Scholarships

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Molecular Biology PhD Projects, Programmes & Scholarships

We have 540 Molecular Biology PhD Projects, Programmes & Scholarships

Studying a PhD in Molecular Biology would provide you with the chance to guide your own research project. With a strong link to Cell Biology, Molecular Biology projects revolve around understanding the composition, structure, and interaction of molecules within the cell that control its function. These are generally laboratory-based projects.

What’s it like to do a PhD in Molecular Biology?

As a PhD student in Molecular Biology, you’ll develop extensive laboratory skills including DNA sequencing, expression cloning, gene knockout, and DNA or protein arrays. Your understanding of the range of techniques available to you will continually improve as you’ll read the latest publications in the field.

Some typical research topics in Molecular Biology include:

  • Understanding the role of a certain protein within a cell
  • Investigating DNA repair mechanisms and potential faults
  • Studying the difference in post-translational modifications in response to stimuli
  • Development of novel therapeutics
  • Investigating how proteins act differently in a disease
  • Studying DNA replication

A majority of Molecular Biology projects are proposed in advance by the supervisor and are advertised on the university website. Some of these projects are fully-funded by the university or a doctoral training programme, while others require you to self-fund.

Suggesting a project for yourself is uncommon in Molecular Biology, due to the challenge of finding funding to cover PhD and bench fees, as well as having to find a supervisor with suitable equipment and research interests to support your project.

Day-to-day, you’ll be in the laboratory preparing or conducting experiments, analysing previous data, creating figures, and writing up the results, alongside quick chats with your colleagues and supervisors about your work.

In the final year of your PhD, you’ll complete an original thesis of approximately 60,000 words in length and give an oral defence of this during a viva exam.

Entry requirements

The entry requirements for most Molecular Biology PhD programmes involve a Masters in a subject directly related to Biology, with at least a Merit or Distinction. If English isn’t your first language, you’ll also need to show that you have the right level of language proficiency.

PhD in Molecular Biology funding options

The research council responsible for funding Molecular Biology PhDs in the UK is the Biotechnology and Biological Sciences Research Council (BBSRC). They provide fully-funded studentships including a stipend for living costs, a consumables budget for bench fees and a tuition fee waiver. Students don’t apply directly to the BBSRC, you apply for advertised projects with this funding attached.

It’s uncommon for Molecular Biology PhD students to be ‘self-funded’ due to the additional bench fees. However, if you were planning to fund yourself it might be achievable (depending on your project) through the UK government’s PhD loan and part-time work.

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Revealing Reactivity in Cancer-Associated Heme Proteins: Novel Time-Resolved Structural Approaches

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme involved in the degradation of tryptophan to kynurenine. Cancer cells upregulate IDO1 to escape normal immune responses and, in many cases, a high expression of IDO1 is connected to poor prognosis. Read more

Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more

Self-funded PhD- Re-engineering Golgi dynamics in plants – investigating the role of myosin receptors

The growing global population requires the development of novel strategies to sustainably increase food production. Organelle movement is dynamic and linked to changes in cell size, plant biomass and in response to factors which affect food production such as pathogens (Perico and Sparkes, New Phytol. Read more

Linking metabolism and metal resistance in pathogenic bacteria (SULLIVANM_U24AMSSCI)

Primary supervisor - Dr Matthew Sullivan. Group B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Read more

Self-funded MSc R- Re-engineering Golgi dynamics in plants – investigating the role of myosin receptors

The growing global population requires the development of novel strategies to sustainably increase food production. Organelle movement is dynamic and linked to changes in cell size, plant biomass and in response to factors which affect food production such as pathogens (Perico and Sparkes, New Phytol. Read more

Biodesigning the future of scent experience using microbial organisms

Based at Central Saint Martins, UAL, in collaboration with Haeckels. Project overview. Working with microbial organisms such as bacterial, algae, fungi and yeasts, this project aims to explore how scents of the future can be produced, designed and experienced. Read more

Natural products in bacterial physiology and chemical interaction

Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more

Development of miRNAs as a new therapeutic tool in the treatment of cardiovascular diseases

Ischemic heart diseases and their pathological consequences belong to the leading causes of death worldwide. In the acute treatment of myocardial ischemia one of the most important tasks is the restoration of the tissue perfusion. Read more

Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more

Application and development of bioinformatics and network theory methods in cardiovascular disease research and pharmacovigilance

To be able to discover novel drug targets we aim to develop software based on network theoretic approaches that are capable to identify mediators and pathways involved in the pathomechanism of various cardiovascular diseases by the analysis of datasets assessed with high throughput molecular biological techniques (e.g. Read more

Nuclear and transcriptional dysregulations during cellular senescence

Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more

Molecular level understanding of Mycobacterium tuberculosis

Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more

(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

(MRC DTP CASE) Investigating the mechanisms contributing to impaired regulatory function of B cells in autoimmunity

The implementation of biological therapies has significantly advanced the management of autoimmune diseases (AIDs). However, the failure to achieve clinical remission in ‘non-responders’ remains a significant and unmet challenge. Read more

(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more

Fully Funded PhD Scholarship in Centrosome Biology

Applications are invited from suitably qualified candidates for a 4-year, full-time funded PhD scholarship(s) starting in June-October 2024 affiliated to the School of Biological and Chemical Sciences at the University of Galway. Read more

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