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Molecular Biology (3d) PhD Projects, Programs & Scholarships

We have 42 Molecular Biology (3d) PhD Projects, Programs & Scholarships

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  3D Super-Resolution Correlative Light-Electron Microscopy of the Protein Complexes
  Prof Dirk-Peter Herten, Dr I Styles
Application Deadline: 28 February 2020

Funding Type

PhD Type

Inflammation plays an important role in the development and progression of cardiovascular diseases. The modulation of inflammation and immunity by CD4+ regulatory T-cells has therefore received increasing attention.
  MRC DTP 4 Year PhD Programme: Deciphering the role of oxidative stress in cardiovascular disease using physiological and 3D cell models.
  Dr C Murdoch, Dr C Henderson
Application Deadline: 13 March 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Using a novel 3D co-culture model to define metabolic flux maps of different cancer cell types in response to physical activity
  Dr M Morris, Dr A Islam, Prof M.P. Lewis
Applications accepted all year round

Funding Type

PhD Type

During exercise, and in the presence of sufficient oxygen, glucose is metabolised by muscle cells to produce pyruvate, a metabolic intermediate which is fed into the Kreb’s cycle in the mitochondria to produce large amounts of energy.
  The role of the breast microenvironment in suppressing early cancer invasion
  Assoc Prof B Parker, Dr D Zanker
Applications accepted all year round

Funding Type

PhD Type

Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer, whereby the tumour cells remain restrained by myoepithelial cells that surround breast ducts.
  A functional proteomic approach to reveal how receptor tyrosine kinases trafficking specifies cancer cell responses
  Dr C Francavilla, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Background and goals. Cells respond appropriately to their surroundings by activating plasma membrane spanning receptors like Receptor Tyrosine Kinases (RTKs) and thereby adapting long-term outputs (e.g.
  Evolution and conservation of membrane-associated effector proteins in plant pathogens
  Dr CN Meisrimler
Application Deadline: 25 February 2020

Funding Type

PhD Type

We seek a PhD candidate to join a 3-year research program based at the University of Canterbury (UC) to investigate the 3D structure of effector proteins targeting the membrane associated NAC transcription factors.
  Anti-cancer activities of dietary phytochemicals (BaoY-PshezhetskiyDU19SF)
  Dr Y Bao, Prof D Pshezhetskiy
Application Deadline: 31 May 2020

Funding Type

PhD Type

Epidemiological studies show that dietary phytochemicals such as isothiocyanates (ITCs) derived from cruciferous vegetables can decrease the risk of many types of cancer.
  The functional characterization of the tumour suppressor gene CSMD1 in breast cancer
  Dr S Bell
Applications accepted all year round

Funding Type

PhD Type

CUB and Sushi multiple domains protein 1 (CSMD1) maps to 8p23, a region deleted in many cancers including breast cancer. Our previous work has established that CSMD1 is an independent prognostic marker in ductal breast cancer, with reduced expression associated with high tumour grade and poor survival1.
  LaNts and laminins in breast cancer
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The laminins are a family of proteins that make up part of specialised regions of extracellular matrix termed basement membranes.
  Bioinformatics studies of protein structures, functions and their interactions
  Dr L J McGuffin
Applications accepted all year round

Funding Type

PhD Type

The computational study of protein structures, functions and their interactions is fundamental to our understanding of disease.
  ’Follow my leader’: in vitro studies of oral cancer cell motility
  Dr S Whawell, Dr H Colley
Applications accepted all year round

Funding Type

PhD Type

Oral cancer cell invasion is a crucial step in the progression of the disease and is mediated by interactions with the extra cellular matrix and factors released by the tumour cells as well as cells that occupy the tumour microenvironment (stroma).
  Characterisation of in vitro models of human salivary glands and their use in functional studies
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Saliva is produced by three pairs of major salivary glands and multiple minor glands in the lips, associated with the tongue and also with the palate.
  EPSRC Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine (LifETIME)

Funding Type

PhD Type

The CDT will train the next generation of leaders in developing in vitro tissues, sensing and diagnostics to develop humanised in vitro systems to drive better drug screening.
  FoodBioSystems DTP - Reducing seed loss and waste in umbelliferous crops
  Dr S Kourmpetli, Dr L Bell
Application Deadline: 6 March 2020

Funding Type

PhD Type

Research Group. FOODBIOSYSTEMS BBSRC DTP. Umbelliferae species flower and set seed over a period of about 6 weeks depending on weather conditions.
  PhD position - Structural basis of melanogenesis enzymes
  Dr M Soler-Lopez
Applications accepted all year round

Funding Type

PhD Type

Ref. InnovaXN_17_ESRF. Categorisation. Places of work. - Grenoble, Rhône-Alpes, France. Contract type. Contract, start on 2020-09-07.
  Investigating the role of connexins in the gingival response to the oral microbiota
  Dr J Butcher, Dr C Wright, Dr P Martin
Applications accepted all year round

Funding Type

PhD Type

Project reference number. SHLS19005. Periodontal disease (PD) is a chronic inflammatory and bone destructive disease that imposes a substantial social and economic burden, and has been linked to the initiation and progression of cardiovascular disease, diabetes, rheumatoid arthritis, and Alzheimer’s disease.
  FGFR signalling in breast cancer
  Dr A Chioni
Applications accepted all year round

Funding Type

PhD Type

Growth factors are used during development to convey messages that tell cells to divide, survive, migrate and adopt a particular fate.
  Towards a Tissue Engineered Model of a Joint on a Chip
  Prof M.P. Lewis, Dr A Capel
Applications accepted all year round

Funding Type

PhD Type

This research project aims to develop a multi-tissue platform that integrates many of the structural tissue components of a musculoskeletal joint; bone, tendon, muscle, cartilage and ligament.
  Vascularisation of tissue engineered skeletal muscle
  Prof M.P. Lewis, Dr A Capel
Applications accepted all year round

Funding Type

PhD Type

Tissue engineering strategies have created a large number of functional tissues constructed from cells and matrix components over the past two decades.
  EPSRC Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine (LifETIME)

Funding Type

PhD Type

The CDT will train the next generation of leaders in developing in vitro tissues, sensing and diagnostics to develop humanised in vitro systems to drive better drug screening.
  Barbour Foundation PhD Studentship - Cancer Prevention with Aspirin in the Ageing Gut (Biosciences Institute)
  Dr L Greaves, Dr M Jackson
Application Deadline: 11 March 2020

Funding Type

PhD Type

Number of awards. 1. Start date and duration. October 2020 for 3 years. Overview. Prevention is better than cure, and it has been shown that aspirin can significantly reduce the incidence of colorectal cancers if taken regularly.
  Modelling of Oral Neutrophil Epithelial interactions
  Dr E Hagi-Pavli
Applications accepted all year round

Funding Type

PhD Type

Background and Clinical Significance. Neutrophils are an important and vital cellular component of the innate immune system providing rapid protection against microbial invasion.
  Enhancing radiotherapy sensitisation and improving cancer control by modulating tumour microenvironment derived angiocrine signalling
  Prof K Hodivala-Dilke, Dr S Boulton
Application Deadline: 16 March 2020

Funding Type

PhD Type

Background. Radiotherapy resistance constitutes a major limitation for effective cancer treatment, emphasising the need to understand the mechanism(s) of radiotherapy sensitisation.
  Characterising surface properties of protein biopharmaceutical molecules
  Dr A Golovanov, Dr J Warwicker
Applications accepted all year round

Funding Type

PhD Type

Protein biologicals have great potential for the effective treatment of a wide range of diseases. However, aggregation and instability are inherent issues with all protein pharmaceuticals, which is a problem that can limit their utility and developability.
  (WIS) Deciphering escape from senescence in vivo
  Prof P Townsend, Prof A D Whetton
Application Deadline: 6 March 2020

Funding Type

PhD Type

Senescence is a dynamic cellular state characterised by a prolonged and generally irreversible cell-cycle arrest that promotes tissue remodelling but it can also have detrimental implications on regenerative capacities of tissues and conduce to inflammation and the progression of ageing-related disease including cancer.
  Building the human endometrium in vitro: The role of macrophages in receptive and decidual endometrium to optimise reproductive health
  Dr E Mann, Dr Peter Ruane, Prof J Aplin, Dr L Mohiyiddeen
Applications accepted all year round

Funding Type

PhD Type

The human endometrium is a highly dynamic tissue that rapidly generates over ~20 days and differentiates to form a uterus lining receptive to embryo implantation, further transforming into decidua to support embryonic development, or breaking down before regenerating a few days later.
  Exploiting tumour-promoting paracrine signals in solid cancers to turbocharge genetically redirected T cells
  Dr A Hurlstone, Prof R Edmondson
Applications accepted all year round

Funding Type

PhD Type

Adoptive cell therapy (ACT) using tumour infiltrating lymphocytes (TILs) or genetically redirected T cells are some of the most promising approaches to emerge recently for the treatment of metastatic disease.
  Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
  Prof A Sharrocks, Prof M Rattray
Applications accepted all year round

Funding Type

PhD Type

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity.
  EPSRC Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine (LifETIME)

Funding Type

PhD Type

The CDT will train the next generation of leaders in developing in vitro tissues, sensing and diagnostics to develop humanised in vitro systems to drive better drug screening.
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