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Molecular Biology (information studies) PhD Projects, Programs & Scholarships

We have 141 Molecular Biology (information studies) PhD Projects, Programs & Scholarships

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  Inhibition of PRMT5 as a cancer therapy
  Dr K. Sheppard
Applications accepted all year round

Funding Type

PhD Type

Targeted therapy has had profound impact on outcomes for cancer patients.
  Bioinformatics studies of protein structures, functions and their interactions
  Dr L J McGuffin
Applications accepted all year round

Funding Type

PhD Type

The computational study of protein structures, functions and their interactions is fundamental to our understanding of disease.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  Predicting the development of oral cancer
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Human head and neck cancer is a devastating disease with poor survival rates.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Watching the Hippo pathway in real time in growing organs
  Dr K. Harvey
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  Developing GWAS approaches to decipher the drivers of Bordetella pertussis adaptation during re-emergence
  Dr A Preston
Application Deadline: 8 March 2020

Funding Type

PhD Type

Genome rearrangement, the reordering of genes along the chromosome, is widespread among bacteria. It is thought to affect bacterial phenotype (behaviour) and contribute to their evolution and adaptation.
  Endothelial receptor antagonists in experimental models of pulmonary hypertension: Cellular and right ventricular studies.
  Dr D Welsh, Dr Y Dempsie
Application Deadline: 3 February 2020

Funding Type

PhD Type

REF SHLS-20003 Welsh. Background. Pulmonary hypertension (PH) is a general name for a group of progressive vasculopathies of the pulmonary vasculature.
  Genetic mechanisms of chronic kidney disease
  Prof M Tomaszewski, Prof A Woolf
Applications accepted all year round

Funding Type

PhD Type

Chronic kidney disease (CKD) is one of the most common complex disorders. The prevalence of CKD is on the rise in all populations around the globe and both the clinical and economic pressures of CKD on the healthcare systems increase exponentially.
  Oxidative protein folding of industrially and pharmaceutically important recombinant proteins
  Dr H Lu, Dr A Day
Applications accepted all year round

Funding Type

PhD Type

Oxidative protein folding is an important process for the function of many proteins, which includes both folding and formation of native disulphide bonds.
  Defining a novel assembly pathway in ssRNA viruses using X-ray footprinting.
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Project co-supervised by Prof. Peter Stockley at Leeds and Prof. Reidun Twarock at University of York, as part of the White Rose network "Structural and Mechanistic Biology at the RNA/Ligand Interface".
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  Fueling chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Triple-negative breast cancer (TNBC) is a molecularly heterogeneous group of diseases defined by the lack of estrogen receptor (ER), progesterone receptor (PR) and absence of human epidermal growth factor receptor-2 (HER2) amplification.
  Testing the function of immune suppressive cytokines and cells in bone metastasis
  Assoc Prof B Parker
Applications accepted all year round

Funding Type

PhD Type

Bone metastasis is a common occurrence in breast and prostate cancer that leads to patient morbidity and, in many cases, mortality.
  Understanding the mechanism of RNA recognition by La-related proteins
  Prof MR Conte
Applications accepted all year round

Funding Type

PhD Type

A PhD studentship is available to work in the laboratory of Prof. Sasi (Maria R) Conte (https://www.kcl.ac.uk/people/sasi-conte), in the Randall Centre for Cell and Molecular Biophysics, King’s College London (https://www.kcl.ac.uk/lsm/research/divisions/randall).
  Investigation of a probiotic strain of Lactobacillus plantarum 2025 and the development of novel antibacterials
  Prof A Karlyshev
Applications accepted all year round

Funding Type

PhD Type

Background. The rise of multidrug resistant forms of microbial pathogens imposes a serious problem to public health worldwide. The rapid spread of antimicrobial resistance is associated with misuse of conventional antibiotics.
  Micro-environmental Interactions And Non-Coding RNAs In The Biology Of B Cell Leukemia
  Prof M Mráz
Application Deadline: 20 February 2020

Funding Type

PhD Type

We are looking for motivated PhD students for a project funded by the prestigious ERC (European Research Council) Grant (laboratory of Assoc.
  Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
  Dr A Kitmitto, Dr E Cartwright
Applications accepted all year round

Funding Type

PhD Type

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Application Deadline: 1 April 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Myocardial biology with a specific focus on the mechanisms underlying cardiac fibrosis and atrial fibrillation
  Dr S Reilly, Prof C Redwood, Assoc Prof M Lei
Application Deadline: 24 July 2020

Funding Type

PhD Type

Cardiac fibrosis is a hallmark histological feature of structural changes in the myocardium associated with virtually all cardiac diseases (e.g., heart failure, hypertension, atrial fibrillation and myocarditis).
  Characterisation of in vitro models of human salivary glands and their use in functional studies
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Saliva is produced by three pairs of major salivary glands and multiple minor glands in the lips, associated with the tongue and also with the palate.
  Splicing control in tumour angiogenesis. Self funded Medical Studies PhD
  Dr S Oltean
Application Deadline: 27 January 2020

Funding Type

PhD Type

Lead supervisor. Dr Seb Oltean, College of Medicine and Health, University of Exeter. Project description. Abnormal angiogenesis is one of the hallmarks of cancer; tumours need to grow new vessels to be able to survive and spread in the organism.
  Expanded potential stem cells for regenerative medicine, immunotherapy, and biotechnology
  Prof P Liu
Applications accepted all year round

Funding Type

PhD Type

Embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells) are pluripotent and thus hold great promise in regenerative medicine, studying disease mechanisms and drug discovery.
  Understanding the role of the pericardial adipose and locally synthesized steroids in the heart
  Prof LM Delbridge, Dr JR Bell
Applications accepted all year round

Funding Type

PhD Type

Applications are invited for a PhD student to join the Cardiac Phenomics laboratory at the University of Melbourne. Our University is ranked 9th in the world for pre-clinical biomedical research (Times Higher Education).
  A multiple modality approach for targeting treatment-resistant ovarian cancer
  Dr E. Sanij, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer (HGSOC) accounts for 70% of ovarian cancer (OvCa) deaths and its five-year survival rate is 43%.
  Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism in liver cancer
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

The Hippo/Yap pathway is an evolutionarily conserved cascade that plays a fundamental role in governing organ size control, stem cell homeostasis and cancer.
  Genomic determinants of long-term survival in ovarian cancer
  Research Group: Cancer Genetics & Genomics Laboratory
  Prof D. Bowtell, Dr D Garsed
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer is an aggressive disease in which only ~30% of women survive 5 years or more. Despite a poor prognosis, a subset of patients are highly responsive to chemotherapy, and some become long-term survivors (>10 years survival).
  Investigating the requirements of pro-inflammatory signaling in skin and head & neck Squamous Cell Carcinomas
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Squamous cell carcinomas (SCC) are amongst the most common cancer types afflicting man. SCCs most frequently arise from stratified squamous epithelia such as the epidermis or the mucosae of the head and neck.
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