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Molecular Biology (january) PhD Projects, Programs & Scholarships

We have 48 Molecular Biology (january) PhD Projects, Programs & Scholarships

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  Determining novel molecular regulators of necrosis controlling premature cell death
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases.
  Differential ion mobility spectrometry and mass spectrometry for proteomics
  Prof H J Cooper
Applications accepted all year round

Funding Type

PhD Type

Research in our laboratory focuses on the application of state-of-the-art mass spectrometry techniques to the global analysis of peptides and proteins.
  Regulation of apoptosis-induced compensatory cell proliferation and its implications for cancer and tissue regeneration
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

In multi-cellular organisms, coordinated cell death (e.g. apoptosis) and cell replacement is critical for tissue recovery in response to stress or damage.
  Fully Funded 4 year MRes-PhD studentships

Funding Type

PhD Type

Do you want to make a difference in patients' lives? Are you interested in combatting major global infectious diseases? Do you want advanced training in…
  Fully-funded PhD positions in several natural sciences & engineering disciplines

Funding Type

PhD Type

Join an internationally renowned scientific community with the Hector FellowPhD program. PhD students benefit not only from the experience of the program, but also from the network of Hector Fellows.
  Investigate a novel, unexplored link between WNT signalling and regulators of cell migration in cancer progression using CRISPR-Cas9 and advanced live cell imaging.
  Dr M Krause
Applications accepted all year round

Funding Type

PhD Type

Cancer is a devastating disease. more than one in three people in the UK will develop cancer in their lifetime. WNT signalling is a key pathway controlling morphogenesis in embryos and it has been shown that perturbations of this pathway promote cancer progression.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  EPSRC CDT in Integrated Catalysis – iCAT

Funding Type

PhD Type

Applications from eligible candidates are invited for fully-funded (fees and stipend) four-year PhD studentships, to integrate the second cohort of the EPSRC CDT in Integrated Catalysis (iCAT CDT) at The University of Manchester, starting in October 2020.
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round

Funding Type

PhD Type

In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  Developing optogenetic therapies for retinal degeneration
  Prof R Lucas, Dr Nina Milosavljevic
Applications accepted all year round

Funding Type

PhD Type

Retinal degeneration is the leading cause of blindness in developed countries. The new exciting biological approach of optogenetic therapy in which ectopic expression of photosensitive proteins (photopigments) is used to restore photosensitivity, offers a potential breakthrough for treating these conditions.
  Dissecting the role of MCE proteins in Cyanobacteria
  Dr V Darbari, Prof C Mullineaux
Applications accepted all year round

Funding Type

PhD Type

The School of Biological and Chemical Sciences at Queen Mary is one of the UK’s elite research centres, according to the 2014 Research Excellence Framework (REF).
  Adaptation of Pseudomonas aeruginosa in people with bronchiectasis during chronic inhaled treatment
  Dr L Sherrard, Dr M Tunney
Applications accepted all year round

Funding Type

PhD Type

Some individuals with bronchiectasis have respiratory infections with Pseudomonas aeruginosa which may lead to a worse clinical trajectory.
  Computational prospecting of bacteriophage genomes and prophages for biotechnologically and pharmaceutically relevant enzymes
  Dr T Skvortsov
Applications accepted all year round

Funding Type

PhD Type

The number of bacteriophage genomes available in public databases keeps growing, but the problem of accurate prediction of functions of bacteriophage genes remains far from being solved.
  Dissecting novel mechanisms of cysteine protease biology in tumourigenesis
  Dr R Burden, Prof C Scott
Applications accepted all year round

Funding Type

PhD Type

Proteases are known for their role in facilitating tumour development, primarily through processes such as proliferation and invasion.
  Synthesis of ribonucleosides using biocatalytic cascades
  Prof N Turner, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Background – Current state of the art for the synthesis of Anti-Sense Oligonucleotides employs solid phase synthesis. The ASOs are assembled from individual ribonucleotides which themselves are often requiring complicated multistep routes to prepare.
  Characterisation of DNA-protein crosslink proteolysis repair in cancer and therapy
  Prof K Ramadan, Prof B Kessler
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. DNA-protein crosslinks (DPCs) are under-investigated DNA lesions caused by the covalent attachment of proteins to DNA.
  Combining CRISPR and RNAseq to dissect molecular circuits in a hypoxic tumour microenvironment
  Prof F Buffa, Prof A Harris, Dr V D'Angiolella
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. The role of the microenvironment in driving tumour progression is increasingly recognized. Hypoxia is one of the key microenvironmental changes between tumour and normal tissue, and adaptation of cancer cells to this hostile environment contributes to their malignancy and aggressive phenotype.
  Cross presentation of antigens of recombinant overlapping peptides to optimise vaccines against tumour and infectious diseases
  Dr S Jiang, Dr N Burgess-Brown
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. We have developed a technology to producing overlapping peptides - bacterial expression of an amino acid sequence corresponding to overlapping peptide sequences spanning the length of a protein of interest interspersed with enzymatic cleavage sites.
  Hypoxia links the unfolded proteim response with the DNA damage response
  Prof E Hammond, Prof A Giaccia
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. Regions of hypoxia (insufficient oxygen) occur in most if not all solid tumours and are clinically relevant as they correlate with poor patient prognosis and therapy resistance.
  Inflammation in the tumour microenvironment
  Dr E Parkes, Dr J Rehwinkel
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. A key part of tackling cancer is understanding the tumour microenvironment, in particular the immune microenvironment.
  Investigating IGF-1 as a cancer risk factor
  Prof V Macaulay, Prof C Verrill
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. The focus of this research project is the investigation of insulin-like growth factors (IGFs) as risk factors for development of cancer.
  Investigation of the contribution of redox stress to the therapy resistance of cells experiencing cycling oxygen levels
  Prof E Hammond, Dr S Conway
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. Hypoxia is a major barrier to successful cancer treatment as the more hypoxic a tumour, the less well patients respond.
  Pre-clinical investigations of POLQ inhibitors
  Dr G Higgins, Prof T Humphrey
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. The aim of our research is to improve radiotherapy for cancer patients by making tumour cells more sensitive to radiation without affecting the sensitivity of normal cells.
  Targeting DNA repair to overcome cancer therapy resistance
  Prof P McHugh, Prof T Brown
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. DNA cross-linking drugs and radiotherapy (RT) are used to treat a range of tumours including many hard-to-treat cancers (e.g.
  Translating epigenetic control into novel cancer therapeutics
  Prof N La Thangue, Prof D Kerr
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. The retinoblastoma protein pRb is a key tumour suppressor that governs fundamental mechanisms in the G1 to S phase transition of the cell cycle.
  Academic Endocrine Unit: investigating the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis.
  Prof R Thakker, Dr K Lines, Dr M Stevenson, Dr K Kooblall
Application Deadline: 24 July 2020

Funding Type

PhD Type

Other Potential Supervisors. Dr Asha Bayliss. The Academic Endocrine Unit investigates the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis.
  Building the skull – normal and abnormal development
  Prof A Wilkie, Dr S Twigg
Application Deadline: 24 July 2020

Funding Type

PhD Type

Using a combination of patient samples and mouse models, we study the causes and developmental origins of skull malformation. The work ranges from scanning human genome sequences for new mutations, to use of genome editing and single cell transcriptomics to model the developmental causes of these malformations in mice.
  Chromatin remodelling in health and disease
  Dr R Gibbons, Prof D Higgs
Application Deadline: 24 July 2020

Funding Type

PhD Type

It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
  Circadian control of energy metabolism and inflammation
  Prof D Ray
Application Deadline: 24 July 2020

Funding Type

PhD Type

Employing a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, Circadian mechanisms regulate most mammalian physiology, with particular importance in the regulation of innate immunity, through the macrophage in particular, and energy metabolism, regulating liver, adipose and muscle.
  Computational Functional Genomics
  Assoc Prof G Lunter
Application Deadline: 24 July 2020

Funding Type

PhD Type

We are interested in building computational models to understand and predict the functional consequences of mutations in the (human) genome.
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