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University of Liverpool, Institute of Ageing and Chronic Disease Molecular Biology PhD Projects, Programs & Scholarships

We have 12 University of Liverpool, Institute of Ageing and Chronic Disease Molecular Biology PhD Projects, Programs & Scholarships

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Showing 1 to 10 of 12
  Cathepsin Z as a novel potential biomarker for osteoporosis
  Dr D Barraclough, Prof L Ranganath
Applications accepted all year round

Funding Type

PhD Type

Supervisors. Dr. Dong Barraclough, Professor Lakshminarayan Ranganath and Professor Sobhan Vinjamuri.
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  Developing and applying computational methods to understand the genetics of ageing
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Ageing is the chief biomedical challenge of the 21st century, yet it remains a major puzzle of biology. Although it is clear that the process of ageing has a strong genetic component, much work remains to elucidate how the genome regulates ageing.
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round

Funding Type

PhD Type

MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Functional and –omics investigation of neutrophil activation in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots, Dr M Phelan
Applications accepted all year round

Funding Type

PhD Type

Neutrophils are key effector cells in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus and vasculitis.
  microRNAs as tools to regulate senescence of musculoskeletal cells during ageing
  Dr K Whysall, Prof P Clegg
Application Deadline: 22 November 2019

Funding Type

PhD Type

As the ageing population continues to increase, it is important to address ageing-related health issues. There is currently no effective treatments for many common musculoskeletal (MSK) disorders, such as sarcopenia or osteoarthritis, which increase in prevalence during ageing.
  Molecular analysis of neutrophil extracellular traps (NETs) in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots
Applications accepted all year round

Funding Type

PhD Type

Neutrophil extracellular traps (NETs) kill pathogens via the release of chromatin and anti-microbial granule enzymes in an extracellular mesh or “net”.
  Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Ageing is arguably the major biomedical challenge of the 21st century. In model organisms, the process of ageing can be manipulated by both genetic manipulations and dietary interventions.
  The effect of low protein diet on the development of the musculoskeletal system
  Dr A Vasilaki, Prof MJ Jackson, Dr I Kanakis, Dr K Whysall
Applications accepted all year round

Funding Type

PhD Type

Age-related sarcopenia is characterised by reduction in the number of myofibres and motor neurons and an additional weakening of the remaining fibres, causing reduction in muscle mass and function.
  The role of modified microRNAs in fibrosis during ageing
  Dr K Whysall, Prof G Bou-Gharios
Application Deadline: 22 November 2019

Funding Type

PhD Type

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression of multiple mRNAs posttranscriptionally (Brown & Goljanek-Whysall, Aging Res Rev 2015).
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