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University of Liverpool, Institute of Ageing and Chronic Disease Molecular Biology PhD Projects, Programs & Scholarships

We have 11 University of Liverpool, Institute of Ageing and Chronic Disease Molecular Biology PhD Projects, Programs & Scholarships

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Showing 1 to 11 of 11
  A 3Rs approach to assess drug toxicity on the embryo during early pregnancy in vitro
  Dr D Turner, Dr B Wilm
Application Deadline: 13 January 2020

Funding Type

PhD Type

This project offers an exciting opportunity for a motivated student to contribute to new understanding on the effects and safety of drugs taken during pregnancy on the developing embryo.
  Cathepsin Z as a novel potential biomarker for osteoporosis
  Dr D Barraclough, Prof L Ranganath
Applications accepted all year round

Funding Type

PhD Type

Supervisors. Dr. Dong Barraclough, Professor Lakshminarayan Ranganath and Professor Sobhan Vinjamuri.
  Defining the role of NF-𝜅B during embryonic stem cell differentiation
  Dr D Turner, Prof A McArdle
Applications accepted all year round

Funding Type

PhD Type

Mouse Embryonic stem cells (mESCs) are a useful system to probe early development. They can be maintained in a pluripotent state in culture, and differentiated using well-defined protocols to all tissue types of the embryo proper.
  Developing and applying computational methods to understand the genetics of ageing
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Ageing is the chief biomedical challenge of the 21st century, yet it remains a major puzzle of biology. Although it is clear that the process of ageing has a strong genetic component, much work remains to elucidate how the genome regulates ageing.
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round

Funding Type

PhD Type

MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Functional and –omics investigation of neutrophil activation in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots, Dr M Phelan
Applications accepted all year round

Funding Type

PhD Type

Neutrophils are key effector cells in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus and vasculitis.
  Molecular analysis of neutrophil extracellular traps (NETs) in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots
Applications accepted all year round

Funding Type

PhD Type

Neutrophil extracellular traps (NETs) kill pathogens via the release of chromatin and anti-microbial granule enzymes in an extracellular mesh or “net”.
  Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Ageing is arguably the major biomedical challenge of the 21st century. In model organisms, the process of ageing can be manipulated by both genetic manipulations and dietary interventions.
  The effect of low protein diet on the development of the musculoskeletal system
  Dr A Vasilaki, Prof MJ Jackson, Dr I Kanakis, Dr K Whysall
Applications accepted all year round

Funding Type

PhD Type

Age-related sarcopenia is characterised by reduction in the number of myofibres and motor neurons and an additional weakening of the remaining fibres, causing reduction in muscle mass and function.
  Uncovering the mechanisms of cryoprotectant toxicity and improving cryopreservation protocols
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Cryopreservation is the process of placing cells, organs or even whole organisms at low temperatures so that they remain in a state of suspended animation and function is preserved.
  Understanding bone mass using collageneases and aggrecanases
  Prof G Bou-Gharios
Applications accepted all year round

Funding Type

PhD Type

Bone is not only essential for locomotion, support and protection but crucial for many aspects of animal and human health. Specifically, bone is a calcium/phosphorous reservoir, is integral to glucose metabolism, houses the hematopoietic system and cross-talks with renal and reproductive systems.
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