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University of Bristol, School of Biochemistry Molecular Biology PhD Projects, Programs & Scholarships

We have 9 University of Bristol, School of Biochemistry Molecular Biology PhD Projects, Programs & Scholarships

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Showing 1 to 9 of 9
  Adhesion Pathways in Extracellular Matrix Organisation
  Prof J Adams
Applications accepted all year round

Funding Type

PhD Type

The extracellular matrix (ECM) provides structural and mechanical support to tissues and modulates cell phenotype and behaviour in health and disease.
  Developing better biopharmaceuticals using biomolecular simulation and design
  Dr M van der Kamp, Dr C R Pudney, Dr D Cole
Application Deadline: 2 December 2019

Funding Type

PhD Type

This is a CASE studentship, in collaboration with Immunocore (www.immunocore.com), which will include a placement at the company (in Abingdon).
  Effects of transcription on genome stability
  Prof N J Savery
Applications accepted all year round

Funding Type

PhD Type

Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
  Enantioselective polyketide biocatalysis through simulation-led redesign
  Dr M van der Kamp, Prof MP Crump, Dr P Race, Prof S Tsai
Application Deadline: 2 December 2019

Funding Type

PhD Type

Enzymes are remarkable biocatalysts that can work under mild conditions and with high specificity and selectivity. If enzymes could be engineered in a designed way, they might provide an efficient route to new molecules such as pharmaceuticals.
  Local control of synaptic protein synthesis in neurons by microRNA
  Dr J Hanley
Application Deadline: 2 December 2019

Funding Type

PhD Type

Neurons are a unique cell type because they are extremely polarised, with long processes extending millimetres from the nucleus in the cell body.
  Precision Genome Editing using Modulators of dsDNA Break Repair Pathways
  Prof C Berger-Schaffitzel
Application Deadline: 2 December 2019

Funding Type

PhD Type

CRISPR/Cas9 relies on introducing specific double-stranded DNA breaks (DSBs) into the target genome which are then repaired by the predominant host cell DSB repair mechanisms.
  Regulation of neuronal energy production by SUMOylation
  Prof J M Henley, Dr T Craig
Application Deadline: 2 December 2019

Funding Type

PhD Type

The human brain uses 20% of the body’s energy but makes up only 2% of its mass. The 100 billion neurones which make up the functional units of the brain require a constant supply of energy, mostly in the form of glucose, in order to maintain and regulate their membrane potential over their large surface area.
  Single-molecule analysis of the CRISPR associated transposons (CAST)
  Prof M D Szczelkun
Application Deadline: 2 December 2019

Funding Type

PhD Type

A key challenge in the development of programmable genome engineering tools has been the reliable insertion of large DNA sequences into genomes, for example to rescue a mutated gene with a functional copy.
  Structural analysis of the inter-membrane bacterial secretosome
  Prof I Collinson
Application Deadline: 2 December 2019

Funding Type

PhD Type

Protein secretion is essential for life. Bacteria secrete proteins for a wide range of membrane and extracellular activities, including envelope biogenesis, pathogenicity and degradation of antibiotics.
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