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University of Nottingham, School of Life Sciences Molecular Biology PhD Projects, Programs & Scholarships

We have 11 University of Nottingham, School of Life Sciences Molecular Biology PhD Projects, Programs & Scholarships

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School of Life Sciences  University of Nottingham

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We have 11 University of Nottingham, School of Life Sciences Molecular Biology PhD Projects, Programs & Scholarships

Adaptation to environmental change in animals: ecology, evolution and genomics.

How are animals able to live in different environments, with different temperatures, energetic demands, diet, predators, parasites or pH? Thanks to advances in gene sequencing technology, we are in a remarkable period of discovery about the genomic basis of adaptation and how this depends on the intricacies of ecology and environment. Read more

The development of Rab27 inhibitors for treatment of cancer cell invasion and proliferation

Rab27 small GTPases regulate movement and exocytosis of secretory granules in cell types including; melanocytes (melanosomes), T lymphocytes (lytic granules), granulocytes (azurophilic granules) and mast cells [1]. Read more

Conflict and Cooperation in Prokaryote Pangenomes

Prokaryotes mediate most of the biogeochemical cycles on the planet, are responsible for large numbers of diseases and are used in pharmaceutical and biotechnology industries to make new and interesting compounds. Read more

What really makes a bacterial lipoprotein a real lipoprotein? Important implications for developing or improving lipoprotein-based vaccines

Bacterial lipoproteins have attracted much interest as vaccine candidates over recent years. The lipoprotein, Factor H binding protein, of Neisseria meningitidis for example is the sole antigen of Trumenba, the vaccine developed by Pfizer, and is a major component of the Bexsero vaccine developed by GSK. Read more

Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides

The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system. Read more

Sequence variation and epigenomic mechanisms underlying human neuropsychiatric and neurodegenerative diseases

This is the decade of the ‘brain’ and this is also the decade of advancements in ‘genomic technologies’. This project aims to use cutting edge sequencing technologies and molecular approaches to understand susceptibility to human disorders of the brain. Read more

Defining the sequence requirements for neo-centromere function in the fission yeast Schizosaccharomyces pombe

Centromeres are the regions of the chromosome necessary for accurate segregation at cell division. They bind a complex set of proteins called the kinetochore which in turn tethers the chromosome to the microtubules of the spindle at cell division. Read more
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