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University of Nottingham, School of Pharmacy Molecular Biology PhD Projects, Programs & Scholarships

We have 5 University of Nottingham, School of Pharmacy Molecular Biology PhD Projects, Programs & Scholarships

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  CRISPR-Cas9 genome editing and super-resolved live cell imaging to study the extracellular microenvironment at the single molecule level
  Dr A Piccinini, Prof D Heery
Applications accepted all year round

Funding Type

PhD Type

The three-dimensional space around and between mammalian cells is filled with a complex network of extracellular matrix (ECM) molecules, which instruct fundamental processes such as cell survival, differentiation and migration, in addition to providing structural support for cells.
  Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes
  Dr G S Winkler
Applications accepted all year round

Funding Type

PhD Type

Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease.
  Gene Regulation by the KAT6A/MOZ Histone Acetyltransferase
  Prof D Heery
Applications accepted all year round

Funding Type

PhD Type

The human KAT6A and KAT6B genes encode the nuclear proteins MOZ and MORF, which are key gene regulators in development of blood, brain and other tissues.
  Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma
  Dr G S Winkler
Applications accepted all year round

Funding Type

PhD Type

Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes.
  Structure and function of enzyme complexes involved in post-transcriptional gene regulation
  Dr G S Winkler
Applications accepted all year round

Funding Type

PhD Type

Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics.
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